KEGG   ENZYME: 3.4.23.45
Entry
EC 3.4.23.45                Enzyme                                 
Name
memapsin 1;
beta-secretase;
beta-site Alzheimer's amyloid precursor protein cleaving enzyme 2 (BACE2);
ASP1;
Down region aspartic protease
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
Reaction(IUBMB)
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu!Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein
Comment
Can cleave beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease, but is not significantly expressed in human brain. In peptidase family A1, but is atypical in containing a C-terminal membrane-spanning domain.
History
EC 3.4.23.45 created 2003
Orthology
K07747  beta-site APP-cleaving enzyme 2 (memapsin 1)
Genes
HSA25825(BACE2)
PTR747819(BACE2)
PPS100990201(BACE2)
GGO101131488(BACE2)
PON100442149(BACE2)
NLE100598433(BACE2)
HMH116481803(BACE2)
MCC715330(BACE2)
MCF102140609(BACE2)
MTHB126950688
MNI105472608(BACE2)
CSAB103219113(BACE2)
CATY105575468(BACE2)
PANU101022049(BACE2)
TGE112620298(BACE2)
MLEU105542583(BACE2)
RRO104655130(BACE2)
RBB108534721(BACE2)
TFN117095807(BACE2)
PTEH111526175(BACE2)
CANG105520372(BACE2)
CJC100406072(BACE2)
SBQ101041728(BACE2)
CIMI108311241(BACE2)
CSYR103269514(BACE2)
MMUR105868023(BACE2)
LCAT123630753(BACE2)
PCOQ105806870(BACE2)
OGA100960504(BACE2)
MMU56175(Bace2)
MCAL110311491(Bace2)
MPAH110329601(Bace2)
RNO288227(Bace2)
MCOC116086190(Bace2)
ANU117718073(Bace2)
MUN110553487(Bace2)
CGE100764950(Bace2)
MAUA101844196(Bace2)
PROB127227565(Bace2)
PLEU114700348(Bace2)
MORG121461779(Bace2)
MFOT126513584
AAMP119825049(Bace2)
NGI103748454(Bace2)
HGL101717943(Bace2)
CPOC100720853(Bace2)
DORD105993951(Bace2)
DSP122114277(Bace2)
PLOP125351658(Bace2)
NCAR124992931
MMMA107136157(Bace2)
OCU100342092 127486849
OPI101520126(BACE2)
TUP102498668(BACE2)
GVR103589278(BACE2)
CFA100684381 478418(BACE2)
CLUD112661680(BACE2)
VVP112908004(BACE2)
VLG121479488(BACE2) 121486528
NPO129502235(BACE2)
AML100477612(BACE2)
UMR103680727(BACE2)
UAH113256938(BACE2)
UAR123802633(BACE2)
ELK111155713
LLV125093972
MPUF101670860(BACE2)
MNP132012411(BACE2)
MLK131825388(BACE2)
NVS122908281(BACE2)
ORO101382461(BACE2)
EJU114226403(BACE2)
ZCA113916393(BACE2)
MLX118026127(BACE2)
NSU110571122(BACE2)
LWW102735101(BACE2)
FCA101096756(BACE2)
PYU121036454(BACE2)
PCOO112849464(BACE2)
PBG122491153(BACE2)
LRUF124526676
PTG102955826(BACE2)
PPAD109249665(BACE2)
PUC125920716
AJU106965624
HHV120230328(BACE2)
BTA534774(BACE2)
BOM102272554(BACE2)
BIU109560497(BACE2)
BBUB102400736(BACE2)
BBIS104985026(BACE2)
CHX102187812(BACE2)
OAS101102027(BACE2)
BTAX128049008(BACE2)
ODA120856835(BACE2)
CCAD122445355(BACE2)
MBEZ129547972(BACE2)
SSC100517374(BACE2)
CFR102516803(BACE2)
CBAI105081120(BACE2)
CDK105099560(BACE2)
VPC102536824(BACE2)
BACU103014984(BACE2)
LVE103085141(BACE2)
OOR101276476(BACE2)
DLE111163827(BACE2)
PCAD102989241(BACE2)
PSIU116753479(BACE2)
NASI112408587(BACE2)
ECB100058700(BACE2)
EPZ103563066(BACE2)
EAI106829946(BACE2)
MYB102254769(BACE2)
MYD102767911(BACE2)
MMYO118676055(BACE2)
MLF102427816(BACE2)
MNA107543580(BACE2)
PKL118723392(BACE2)
EFUS103289900(BACE2)
HAI109372661(BACE2)
DRO112305990(BACE2)
SHON118984839(BACE2)
AJM119048822(BACE2)
PDIC114490483(BACE2)
PHAS123827923(BACE2)
MMF118617504(BACE2)
RFQ117034943(BACE2)
PPAM129074632(BACE2)
PALE102896199(BACE2)
PGIG120598839(BACE2)
PVP105300589(BACE2)
RAY107498533(BACE2)
MJV108397054(BACE2)
TOD119257185(BACE2)
SARA101541926(BACE2)
LAV100653591(BACE2)
TMU101360622
ETF101653908(BACE2)
DNM101426319(BACE2)
MDO100016587(BACE2)
GAS123242508(BACE2)
SHR100932104(BACE2)
AFZ127553775
PCW110200869(BACE2)
OAA100080196(BACE2)
GGA418526(BACE2)
PCOC116242118(BACE2)
MGP100547969(BACE2)
CJO107323138(BACE2)
TPAI128076411(BACE2)
LMUT125702980(BACE2)
NMEL110403123(BACE2)
APLA101795939(BACE2)
ACYG106036113(BACE2)
CATA118247713(BACE2)
AFUL116485795(BACE2)
TGU100224177(BACE2)
LSR110475869(BACE2)
SCAN103815877(BACE2)
PMOA120511889(BACE2)
OTC121333463(BACE2)
PRUF121364492(BACE2)
GFR102039028(BACE2)
FAB101816221(BACE2)
OMA130257070(BACE2)
PHI102107969(BACE2)
PMAJ107212623(BACE2)
CCAE111929198(BACE2)
CCW104686367(BACE2)
CBRC103612881(BACE2)
ETL114059201(BACE2)
ZAB102065528(BACE2)
ACHL103802824(BACE2)
SVG106855723(BACE2)
MMEA130578109(BACE2)
HRT120749227(BACE2)
FPG101919630(BACE2)
FCH102051138(BACE2)
CLV102088959(BACE2)
EGZ104128185(BACE2)
NNI104020195(BACE2)
PCRI104025588(BACE2)
PLET104625785(BACE2)
EHS104503686(BACE2)
PCAO104049091(BACE2)
ACUN113478950(BACE2)
TALA104368265(BACE2)
PADL103920335(BACE2)
AFOR103902087(BACE2)
ACHC115343812(BACE2)
HLE104839841(BACE2)
AGEN126053203
GCL127021081
CCRI104162065(BACE2)
CSTI104561523
CMAC104483640(BACE2)
MUI104539610(BACE2)
BREG104629664(BACE2)
FGA104070289(BACE2)
GSTE104251217(BACE2)
LDI104340929(BACE2)
OHA104327756(BACE2)
NNT104412472(BACE2)
SHAB115604130(BACE2)
DPUB104305048(BACE2)
PGUU104458710(BACE2)
ACAR104518840(BACE2)
CPEA104391212(BACE2)
AVIT104280971(BACE2)
CVF104292048(BACE2)
RTD128900512(BACE2)
CUCA104059266(BACE2)
TEO104378622(BACE2)
AAM106494905(BACE2)
AROW112971894(BACE2)
NPD112959094(BACE2)
TGT104572262(BACE2)
DNE112996158(BACE2)
SCAM104147147(BACE2)
ASN102386120(BACE2)
AMJ102561959(BACE2)
CPOO109305833(BACE2)
GGN109302738(BACE2)
PSS102447109(BACE2)
CMY102940897(BACE2)
CCAY125643525(BACE2)
DCC119846336(BACE2)
CPIC101938324(BACE2)
TST117867825(BACE2)
CABI116831583(BACE2)
MRV120376150(BACE2)
ACS100552914(bace2)
ASAO132771829(BACE2)
PVT110076824(BACE2)
SUND121925185(BACE2)
PBI103059516(BACE2)
PMUR107288321(BACE2)
CTIG120319913(BACE2)
TSR106556057(BACE2)
PGUT117669474(BACE2)
APRI131199707(BACE2)
PTEX113444798(BACE2)
NSS113416234(BACE2)
VKO123029376(BACE2)
PMUA114596101(BACE2)
PRAF128413034(BACE2)
ZVI118084833(BACE2)
HCG128350757(BACE2)
GJA107124625(BACE2)
STOW125431451(BACE2)
EMC129325997(BACE2)
XLA380307(bace2.L) 398806(bace2.S)
XTR100216145(bace2)
NPR108783971(BACE2)
RTEM120927954(BACE2)
BBUF120994469(BACE2)
BGAR122932842(BACE2)
MUO115470564(BACE2)
GSH117359782(BACE2)
DRE449818(bace2)
SRX107726120 107747683
SANH107655814 107677045
SGH107562815 107598803
CCAR109086471
CAUA113098361 113115343
CGIB127972543 128029401
PTET122358883(bace2)
LROH127177154(bace2)
OMC131520721(bace2)
PPRM120464687(bace2)
RKG130076526(bace2)
MAMB125248797(bace2)
CIDE127496264
MASI127422271 127429494
TROS130564722(bace2)
TDW130428371(bace2)
MANU129437457(bace2)
IPU108280663(bace2)
IFU128624147(bace2)
PHYP113542974
SMEO124403299(bace2)
TFD113653734(bace2)
TVC132849819(bace2)
AMEX103044755
CMAO118796789(bace2)
EEE113585008
CHAR105909666(bace2)
TRU101078612(bace2)
TFS130535302(bace2)
TNGGSTEN00002182G001 GSTEN00005390G001
LCO104921140(bace2)
NCC104967128(bace2)
TBEN117470062(bace2)
CGOB115018082(bace2)
PGEO117457825(bace2)
GACU117551666(bace2)
ELY117260034(bace2)
EFO125888885(bace2)
PLEP121943259(bace2)
SLUC116043868(bace2)
ECRA117942609(bace2)
ESP116672023(bace2)
PFLV114552799(bace2)
GAT120825547(bace2)
PPUG119218890(bace2)
AFB129104700(bace2)
CLUM117741883(bace2)
MSAM119883029(bace2)
SCHU122879092(bace2)
CUD121526372(bace2)
ALAT119009934(bace2)
MZE101466632 112435929
ONL100694039
OAU116330383(bace2)
OLA101167562
OML112149116(bace2)
XMA102236423
XCO114133365
XHE116708119
PRET103474388
PFOR103153985(bace2)
PLAI106960258(bace2)
PMEI106928684(bace2)
GAF122832149(bace2)
PPRL129359359(bace2)
CVG107097200(bace2)
CTUL119783850(bace2)
GMU124883471(bace2)
NFU107380543(bace2)
KMR108238129(bace2)
ALIM106522153(bace2)
NWH119411200(bace2)
AOCE111588940
MCEP125013281(bace2)
CSEM103377589(bace2)
POV109634601
SSEN122765438 122773488(bace2)
HHIP117772960(bace2)
HSP118106667(bace2)
LCF108873776
SDU111239096(bace2)
SLAL111654565(bace2)
XGL120792312(bace2)
HCQ109512909
SSCV125971838
SBIA133504381(bace2)
PEE133405401(bace2)
PTAO133482293(bace2)
BPEC110171890(bace2)
MALB109960296(bace2)
BSPL114868019(bace2)
SJO128360095(bace2)
SASA106581128 106612993
STRU115163493 115206407
OTW112265580 112267157
OMY110503995 110507827
OGO123992685 124006025
ONE115136688 115141881
OKI109905771 109909177
OKE118397489 118402585
SALP111949503 111958149
SNH120018154 120029099
CCLU121558993 121568016
ELS105021658(bace2)
SFM108932129
PKI111844859
AANG118210131(bace2)
LOC102686808(bace2)
PSPA121302783(bace2)
ARUT117406200 117407070
PSEX120523296(bace2)
LCM102362842(BACE2)
CMK103187270(bace2)
RTP109919762(bace2)
CPLA122555395(bace2)
HOC132821180(bace2)
LERI129702993(bace2)
ATEN116293238
ADF107356607
AMIL114957255
PDAM113684213
SPIS111325941
HSY130645718 130645826
PIFPITG_06900 PITG_08190
PSOJPHYSODRAFT_348172 PHYSODRAFT_479874
SPARSPRG_07185
 » show all
Reference
1  [PMID:12093293]
  Authors
Turner RT 3rd, Loy JA, Nguyen C, Devasamudram T, Ghosh AK, Koelsch G, Tang J.
  Title
Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity.
  Journal
Biochemistry 41:8742-6 (2002)
DOI:10.1021/bi025926t
Other DBs
ExplorEnz - The Enzyme Database: 3.4.23.45
IUBMB Enzyme Nomenclature: 3.4.23.45
ExPASy - ENZYME nomenclature database: 3.4.23.45
BRENDA, the Enzyme Database: 3.4.23.45
CAS: 447457-31-0

DBGET integrated database retrieval system