KEGG ENZYME: 3.4.23.47

ENZYME: 3.4.23.47

Entry

EC 3.4.23.47                Enzyme

Name

HIV-2 retropepsin

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases

Reaction(IUBMB)

Endopeptidase for which the P1 residue is preferably hydrophobic

Comment

In peptidase family A2. Responsible for the post-translational processing of the human immunodeficiency virus polyprotein.

History

EC 3.4.23.47 created 2003

Orthology

K22599

HIV protease

Reference

1 [PMID:2015912]

Authors

Tozser J, Blaha I, Copeland TD, Wondrak EM, Oroszlan S.

Title

Comparison of the HIV-1 and HIV-2 proteinases using oligopeptide substrates representing cleavage sites in Gag and Gag-Pol polyproteins.

Journal

FEBS Lett 281:77-80 (1991)
DOI:10.1016/0014-5793(91)80362-7

Reference

2 [PMID:7929352]

Authors

Chen Z, Li Y, Chen E, Hall DL, Darke PL, Culberson C, Shafer JA, Kuo LC.

Title

Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases.

Journal

J Biol Chem 269:26344-8 (1994)

Other DBs

ExplorEnz - The Enzyme Database:

3.4.23.47

IUBMB Enzyme Nomenclature:

3.4.23.47

ExPASy - ENZYME nomenclature database:

3.4.23.47

BRENDA, the Enzyme Database:

3.4.23.47

CAS:	144114-21-6

All links

Gene (3)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (2)   
Protein sequence (38)   
   UniProt (14)   
   SWISS-PROT (12)   
   RefSeq(pep) (2)   
   PDBSTR (10)   
DNA sequence (3)   
   RefSeq(nuc) (3)   
3D Structure (5)   
   PDB (5)   
Protein domain (26)   
   InterPro (26)   
All databases (75)   

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