KEGG   ENZYME: 3.4.24.12
Entry
EC 3.4.24.12                Enzyme                                 
Name
envelysin;
sea-urchin-hatching proteinase;
hatching enzyme;
chorionase;
chorion-digesting proteinase;
chymostrypsin;
sea urchin embryo hatching enzyme
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Hydrolysis of proteins of the fertilization envelope and dimethylcasein
Comment
A glycoprotein from various members of the class Echinoidea. Extracellular enzyme requiring Ca2+. In peptidase family M10 (interstitial collagenase family)
History
EC 3.4.24.12 created 1978
Orthology
K19957  envelysin
Genes
SPU: 578408(HE) 752524
LPIC: 129282298
ATEN: 116286565 116289245 116291179
Reference
1  [PMID:1012003]
  Authors
Barrett D, Edwards BF.
  Title
Hatching enzyme of the sea urchin Strongylocentrotus purpuratus.
  Journal
Methods Enzymol 45:354-73 (1976)
DOI:10.1016/S0076-6879(76)45032-2
Reference
2  [PMID:2925668]
  Authors
Lepage T, Gache C.
  Title
Purification and characterization of the sea urchin embryo hatching enzyme.
  Journal
J Biol Chem 264:4787-93 (1989)
Reference
3  [PMID:2167841]
  Authors
Lepage T, Gache C
  Title
Early expression of a collagenase-like hatching enzyme gene in the sea urchin embryo.
  Journal
EMBO J 9:3003-12 (1990)
DOI:10.1002/j.1460-2075.1990.tb07493.x
  Sequence
[ag:CAA37667]
Reference
4  [PMID:1711895]
  Authors
Nomura K, Tanaka H, Kikkawa Y, Yamaguchi M, Suzuki N
  Title
The specificity of sea urchin hatching enzyme (envelysin) places it in the mammalian matrix metalloproteinase family.
  Journal
Biochemistry 30:6115-23 (1991)
DOI:10.1021/bi00239a005
  Sequence
[spu:752524]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.12
IUBMB Enzyme Nomenclature: 3.4.24.12
ExPASy - ENZYME nomenclature database: 3.4.24.12
BRENDA, the Enzyme Database: 3.4.24.12
CAS: 50812-13-0

  All links  
Gene (8)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (7)   
Protein sequence (25)   
   UniProt (23)   
   SWISS-PROT (2)   
DNA sequence (4)   
   GenBank (2)   
   EMBL (2)   
Protein domain (14)   
   InterPro (12)   
   PROSITE(DOC) (2)   
All databases (51)   

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