KEGG   ENZYME: 3.4.24.13
Entry
EC 3.4.24.13                Enzyme                                 
Name
IgA-specific metalloendopeptidase;
immunoglobulin A1 proteinase;
IgA protease;
IgA1-specific proteinase;
IgA1 protease;
IgA1 proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Cleavage of Pro!Thr bond in the hinge region of the heavy chain of human IgA
Comment
A 190 kDa enzyme found in several pathogenic species of Streptococcus such as sanguis and pneumoniae. Type example of peptidase family M26. There is also an IgA-specific prolyl endopeptidase of the serine-type (see EC 3.4.21.72, IgA-specific serine endopeptidase)
History
EC 3.4.24.13 created 1984
Orthology
K01390  IgA-specific metalloendopeptidase
Genes
GHANCTC10459_00981(iga_2)
SPNSP_1154(zmpA)
SPDSPD_1018(iga)
SPRspr1042(iga)
SPWSPCG_1143(iga)
SJJSPJ_1073
SNVSPNINV200_10720(zmpA)
SPXSPG_1053(igA)
SNTSPT_1181
SNDMYY_1183
SPNNT308_05505
SNESPN23F10580(zmpA)
SPVSPH_1229
SNCHMPREF0837_11342
SNMSP70585_1207
SPPSPP_1140
SNIINV104_09960(zmpA)
SPNGHMPREF1038_01043(iga)
SNBSP670_1202
SNPSPAP_1059
SNXSPNOXC10390(zmpA)
SPNESPN034156_01270(zmpA)
SPNUSPN034183_10390(zmpA)
SPNMSPN994038_10280(zmpA)
SPNOSPN994039_10290(zmpA)
SSASSA_1106(iga)
SORSOR_0589
STDSPPN_05625
STVV470_02665
STRNSNAG_0569(iga_2)
SGWD7D53_06075
SOSINT76_08495
MOENCTC10151_00315(iga_1) NCTC10151_00316(iga_2)
 » show all
Reference
1  [PMID:6792682]
  Authors
Kornfeld SJ, Plaut AG.
  Title
Secretory immunity and the bacterial IgA proteases.
  Journal
Rev Infect Dis 3:521-34 (1981)
DOI:10.1093/clinids/3.3.521
Reference
2  [PMID:1987065]
  Authors
Gilbert JV, Plaut AG, Wright A
  Title
Analysis of the immunoglobulin A protease gene of Streptococcus sanguis.
  Journal
Infect Immun 59:7-17 (1991)
DOI:10.1128/IAI.59.1.7-17.1991
  Sequence
[ssa:SSA_1106]
Reference
3  [PMID:3294181]
  Authors
Gilbert JV, Plaut AG, Fishman Y, Wright A.
  Title
Cloning of the gene encoding streptococcal immunoglobulin A protease and its expression in Escherichia coli.
  Journal
Infect Immun 56:1961-6 (1988)
DOI:10.1128/IAI.56.8.1961-1966.1988
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.13
IUBMB Enzyme Nomenclature: 3.4.24.13
ExPASy - ENZYME nomenclature database: 3.4.24.13
BRENDA, the Enzyme Database: 3.4.24.13
CAS: 72231-73-3

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