KEGG ENZYME: 3.4.24.17

ENZYME: 3.4.24.17

Entry

EC 3.4.24.17                Enzyme

Name

stromelysin 1;
matrix metalloproteinase 3;
proteoglycanase;
collagenase activating protein;
procollagenase activator;
transin;
MMP-3;
neutral proteoglycanase;
stromelysin;
collagen-activating protein

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases

Reaction(IUBMB)

Preferential cleavage where P1', P2' and P3' are hydrophobic residues

Comment

An extracellular endopeptidase of vertebrate tissues homologous with interstitial collagenase. Digests proteoglycan, fibronectin, collagen types III, IV, V, IX, and activates procollagenase. In peptidase family M10 (interstitial collagenase family)

History

EC 3.4.24.17 created 1990

Orthology

K01394

matrix metalloproteinase-3 (stromelysin 1, progelatinase)

Genes

HSA:	4314(MMP3)

PTR:	451511(MMP3)

PPS:	100995831(MMP3)

GGO:	101131989(MMP3)

PON:	100461529(MMP3)

NLE:	100583082(MMP3)

HMH:	116464292 116464293

MCC:	703762(MMP3)

MCF:	102142651(MMP3)

MTHB:

126936369

MNI:	105493711(MMP3)

CSAB:

103248344(MMP3)

CATY:

105588770(MMP3)

PANU:

101000789(MMP3)

TGE:	112607314(MMP3)

MLEU:

105542745(MMP3)

RRO:	104674668(MMP3)

RBB:	108514072(MMP3)

TFN:	117081262(MMP3)

PTEH:

111540075(MMP3)

CANG:

105500946(MMP3)

CJC:

100396218

SBQ:	101051562(MMP3)

CIMI:

108315431(MMP3)

CSYR:

103277140

MMUR:

105874563

LCAT:

123641885

PCOQ:

105822157 105822245

OGA:

100952217

MMU:	17392(Mmp3)

MCAL:

110301975

MPAH:

110327820

RNO:	171045(Mmp3)

MCOC:

116072442

ANU:

117699631

MUN:

110558090

CGE:	100754565(Mmp3)

MAUA:

101834647

PROB:

127233235

PLEU:

114708015

MORG:

121451850

MFOT:

126493288

AAMP:

119810022

NGI:	103731587(Mmp3)

HGL:	101702569 101716622(Mmp3)

CPOC:

100729101(Mmp3)

CCAN:

109689285

DORD:

105980671

DSP:	122110302(Mmp3)

PLOP:

125349681

NCAR:

124958931

MMMA:

107145902

OCU:	100009111(MMP3)

OPI:

101528146

TUP:	102489067(MMP3)

GVR:	103600379(MMP3)

CFA:	403445(MMP3)

CLUD:

112671545

VVP:

112925877

VLG:	121500272(MMP3)

NPO:

129497419

AML:	100477912 100478420

UMR:	103662452 103662454

UAH:	113259796 113259798

UAR:	123792353 123792355

ELK:

111153872

LLV:	125078732 125078733

MPUF:

101688701

MNP:

132013257

MLK:

131834652

NVS:

122913960

ORO:	101368994(MMP3)

EJU:	114211354(MMP3)

ZCA:

113914358

MLX:	118013056(MMP3)

NSU:

110586166

LWW:	102733397 102734593

FCA:

101081492

PYU:

121020779

PCOO:

112866153

PBG:

122482892

PVIV:

125147184

LRUF:

124504841

PTG:

102970292

PPAD:

109257540

PUC:

125910766

AJU:

106976485

HHV:

120223085

BTA:	281309(MMP3)

BOM:	102288330(MMP3)

BIU:

109569248

BBUB:

102413066(MMP3)

BBIS:

104987808(MMP3)

CHX:	102170893(MMP3)

OAS:

101118895

BTAX:

128060536

ODA:	120876149(MMP3)

CCAD:

122450308

MBEZ:

129553537

SSC:	396769(MMP3)

CFR:	102516794(MMP3)

CBAI:

105067594(MMP3)

CDK:	105087168(MMP3)

VPC:	102528182(MMP3)

BACU:

103010042(MMP3)

BMUS:

118899355

LVE:	103089307(MMP3)

OOR:

101270746

DLE:

111167570

PCAD:

102983506

PSIU:

116758766

NASI:

112394563

ECB:	100034195(MMP3)

EPZ:	103552637(MMP3)

EAI:

106843118

MYB:	102252870 102254078

MYD:	102770528(MMP3)

MMYO:

118664459

MLF:

102427039

PKL:

118713270

EFUS:

103292966 129151149

MNA:

107532386

DRO:

112317540

SHON:

118975721

AJM:

119054055

PDIC:

114499511 114500132

PHAS:

123805510

MMF:

118628226

PPAM:

129086041

RFQ:	117031216 117031218

PALE:

102886139

PGIG:

120599686

PVP:

105297467

RAY:

107504635

MJV:	108385898(MMP3)

TOD:	119240915(MMP10)

SARA:

101545129

LAV:

100660303

TMU:

101341271

ETF:	101656613 101657229

DNM:

101447627

MDO:	100011059(MMP3)

GAS:

123238995

SHR:

100934169

AFZ:

127558057

PCW:

110214977

OAA:

100077197

GGA:	418981(MMP10) 428086(MMP3)

PCOC:

116230607 116230616

MGP:	100544485 100544642

CJO:	107308380 107308400

TPAI:

128074805 128074813

LMUT:

125695535 125696936

NMEL:

110389860 110389866

APLA:

101794349 101798488

ACYG:

106034136 106034139

CATA:

118245876 118246039

AFUL:

116493125 116501848

TGU:	100221422 100227226

LSR:	110470043 110470055

SCAN:

103812522 103827285

PMOA:

120506631 120506743

OTC:	121342518 121342531

PRUF:

121364175 121364179

GFR:	102045216 102045385

FAB:	101805628 101805825

OMA:	130252196 130258586

PHI:	102111122 102111311

PMAJ:

107199793 107213689

CCAE:

111924322 111924329

CCW:	104690061 104690062

CBRC:

103617949 103617950

ETL:

114067039

ZAB:	102069814 102069989

ACHL:

103811760 103811761

SVG:	106859369 106859372

MMEA:

130576287 130576288

HRT:	120748617 120749377

FPG:	101924760(MMP3)

FCH:

102050939

CLV:	102089434 102089618

EGZ:	104128904 104128911

NNI:

104023068

PCRI:

104025174 104025526

PLET:

104617149

EHS:

104506190

PCAO:

104045435

ACUN:

113476996 113477018

TALA:

104369555 104369556

PADL:

103915451

AFOR:

103895109 103895110

ACHC:

115353566 115353567

HALD:

104314245 104314246

HLE:	104828448 104828449

AGEN:

126048148 126048150

GCL:	127021506 127021519

CCRI:

104159689 104163036

CSTI:

104549815 104556371

CMAC:

104474429 104474600

MUI:	104535899 104537560

BREG:

104633765 104633767

FGA:	104070480 104081957

GSTE:

104255839 104261779

LDI:	104351208 104351209

MNB:

103781317

OHA:	104333034 104333059

NNT:

104404383

SHAB:

115603822

DPUB:

104296910 104296911

PGUU:

104468646

ACAR:

104532861

CPEA:

104390272 104390273

AVIT:

104268312 104280485

CVF:	104290311 104290323

RTD:	128912492 128914125

CUCA:

104055008 104064703

TEO:	104370475 104370765

BRHI:

104489342

AAM:	106495497 106495502

AROW:

112971953 112971954

NPD:	112943711 112943717

TGT:	104571781 104571785

DNE:	112988744 112988745

SCAM:

104151759 104151760

ASN:	102380481 102386892

AMJ:	102567265 102567499

CPOO:

109305541

GGN:	109302216 109303444

PSS:	102447500 102447922

CMY:	102939197 102940374 102940592

CCAY:

125633993

DCC:	119858306 119858321 119858355

CPIC:

101931498 101931780 101932067

TST:	117871171 117871173 117871798

CABI:

116814903 116837660 116837662

MRV:	120375066 120395683 120407101

ACS:	100552454 100552651 100561433

ASAO:

132770077 132772196 132772197

PVT:	110089066 110089069 110089074

SUND:

121925768 121926153 121926847

PBI:	103067400 103067634

PMUR:

107286365 107286366

CTIG:

120313881 120313882

TSR:

106552777

PGUT:

117664145 117664152

APRI:

131199767 131200037

PTEX:

113440479

NSS:

113417303

VKO:	123029183 123029242 123029250

PMUA:

114595297 114595661 114595664

PRAF:

128412588 128412589 128412592

ZVI:	118084935 118084937

HCG:	128350660 128352362 128352530

GJA:	107119161 107119164 107119165

STOW:

125430820 125431172 125431542

EMC:	129325829 129325831 129325833 129325906 129326303 129326508

XLA:	108707763 108707764 108707765 108708732 108709141 108709142 446898(mmp3.L) 495372(mmp8.S)

XTR:	100489571 100489735 100491214 100491547 100494588(mmp8)

NPR:	108786934 108786935

RTEM:

120929026 120929033 120929034 120929035

BBUF:

120996397 120996398

BGAR:

122930903 122931173

MUO:

115468491

GSH:	117362381 117362513

IPU:	108276913(mmp30)

PHYP:

113544863

AMEX:

103038016

TRU:

101068697

LCO:

104930317

ALIM:

106512532

CSEM:

103377668

POV:	109628507 109634382

LCF:	108893128(mmp30)

SDU:	111222196 111233417

SLAL:

111663517

XGL:	120791805 120802392(mmp30)

HCQ:

109512887

MALB:

109972892

LOC:

102685380

ARUT:

117406493

CMK:	103177428 103177583

CPLA:

122550420 122550421 122551103 122551104

HOC:	132816339 132816340 132816341

BBEL:

109482489

MQU:

128999143

FOC:

113213637

PDAM:

113674030

» show all

Reference

1 [PMID:2995374]

Authors

Chin JR, Murphy G, Werb Z.

Title

Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates.

Journal

J Biol Chem 260:12367-76 (1985)

Reference

2 [PMID:3095317]

Authors

Okada Y, Nagase H, Harris ED Jr.

Title

A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization.

Journal

J Biol Chem 261:14245-55 (1986)

Reference

3 [PMID:2197998]

Authors

Docherty AJ, Murphy G.

Title

The tissue metalloproteinase family and the inhibitor TIMP: a study using cDNAs and recombinant proteins.

Journal

Ann Rheum Dis 49:469-79 (1990)

Reference

4 [PMID:2165861]

Authors

Emonard H, Grimaud JA.

Title

Matrix metalloproteinases. A review.

Journal

Cell Mol Biol 36:131-53 (1990)

Other DBs

ExplorEnz - The Enzyme Database:

3.4.24.17

IUBMB Enzyme Nomenclature:

3.4.24.17

ExPASy - ENZYME nomenclature database:

3.4.24.17

BRENDA, the Enzyme Database:

3.4.24.17

CAS:	79955-99-0

DBGET integrated database retrieval system