KEGG ENZYME: 3.4.24.22

ENZYME: 3.4.24.22

Entry

EC 3.4.24.22                Enzyme

Name

stromelysin 2;
matrix metalloproteinase 10;
transin 2;
proteoglycanase 2

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases

Reaction(IUBMB)

Similar to stromelysin 1, but action on collagen types III, IV and V is weak

Comment

In peptidase family M10 (interstitial collagenase family). Digests gelatin types I, III, IV, V, fibronectin and proteoglycan

History

EC 3.4.24.22 created 1992

Orthology

K01396

matrix metalloproteinase-10 (stromelysin 2)

Genes

HSA:	4319(MMP10)

PTR:	740658(MMP10)

PPS:	100996180(MMP10)

GGO:	101131626(MMP10)

PON:	100460793(MMP10)

NLE:	100583748(MMP10)

HMH:	116477419(MMP10)

MCC:	701793(MMP10)

MCF:	102142363(MMP10)

MTHB:

126936365

MNI:

105493707

CSAB:

103248336(MMP10)

CATY:

105588777(MMP10)

PANU:

101001136(MMP10)

TGE:	112607315(MMP10)

MLEU:

105542741(MMP10)

RRO:	104674664(MMP10)

RBB:	108514075(MMP10)

TFN:	117081357(MMP10)

PTEH:

111540070(MMP10)

CANG:

105500943(MMP10)

CJC:	100395869(MMP10)

SBQ:	101051882(MMP10)

CIMI:

108315432(MMP10)

MMUR:

105874562(MMP10)

LCAT:

123641887(MMP10)

OGA:	100951593(MMP10)

MMU:	17384(Mmp10)

MCAL:

110301994(Mmp10)

MPAH:

110328053(Mmp10)

RNO:	117061(Mmp10)

MCOC:

116072391(Mmp10)

ANU:	117699835(Mmp10)

MUN:

110541845

CGE:	100755142(Mmp10)

MAUA:

110342258(Mmp10)

PROB:

127233231(Mmp10)

PLEU:

114708017(Mmp10)

MORG:

121451780(Mmp10)

MFOT:

126513694

AAMP:

119810122(Mmp10)

NGI:	103731570(Mmp10)

HGL:	101697990(Mmp10)

CPOC:

100727690(Mmp10)

CCAN:

109689287(Mmp10)

DORD:

105980686(Mmp10)

DSP:	122110406(Mmp10)

PLOP:

125348069(Mmp10)

NCAR:

124958975

MMMA:

107145715(Mmp10)

OCU:

100101603

OPI:	101527385(MMP10)

GVR:	103581113(MMP10)

VLG:	121500904(MMP10)

ELK:

111153715

MPUF:

101672187

ORO:	101369596(MMP10)

EJU:

114211376

ZCA:	113915036(MMP10)

MLX:	118013054(MMP10)

NSU:	110586226(MMP10)

FCA:	101081247(MMP10)

PYU:

121020774

PCOO:

112866152

PBG:

122482470

PVIV:

125176789(MMP10)

LRUF:

124504838

PTG:

102951156

PPAD:

109257539

PUC:

125910782

AJU:

106976488

HHV:	120223087(MMP10)

ECB:

100146442

MYD:	102753365(MMP10)

SHON:

118975719

AJM:

119054051

PALE:

102885902(MMP10)

PGIG:

120599668

RAY:

107504634

LAV:	100660014(MMP10)

TMU:

101341774

DNM:

101411541

XTR:	594917(mmp3)

FEX:	115237365 115241263

PVUL:

126824291

» show all

Reference

1 [PMID:3547333]

Authors

Breathnach R, Matrisian LM, Gesnel MC, Staub A, Leroy P.

Title

Sequences coding for part of oncogene-induced transin are highly conserved in a related rat gene.

Journal

Nucleic Acids Res 15:1139-51 (1987)
DOI:10.1093/nar/15.3.1139

Sequence

[rno:117061]

Reference

2 [PMID:2844164]

Authors

Muller D, Quantin B, Gesnel MC, Millon-Collard R, Abecassis J, Breathnach R

Title

The collagenase gene family in humans consists of at least four members.

Journal

Biochem J 253:187-92 (1988)
DOI:10.1042/bj2530187

Sequence

[hsa:4319]

Reference

3 [PMID:2548603]

Authors

Nicholson R, Murphy G, Breathnach R.

Title

Human and rat malignant-tumor-associated mRNAs encode stromelysin-like metalloproteinases.

Journal

Biochemistry 28:5195-203 (1989)
DOI:10.1021/bi00438a042

Other DBs

ExplorEnz - The Enzyme Database:

3.4.24.22

IUBMB Enzyme Nomenclature:

3.4.24.22

ExPASy - ENZYME nomenclature database:

3.4.24.22

BRENDA, the Enzyme Database:

3.4.24.22

CAS:	140610-48-6

All links

Gene (87)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (86)   
Protein sequence (23)   
   UniProt (7)   
   SWISS-PROT (3)   
   RefSeq(pep) (4)   
   PDBSTR (9)   
DNA sequence (9)   
   RefSeq(nuc) (4)   
   GenBank (3)   
   EMBL (2)   
3D Structure (3)   
   PDB (3)   
Protein domain (14)   
   InterPro (12)   
   PROSITE(DOC) (2)   
All databases (136)   

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