KEGG   ENZYME: 3.4.24.25
Entry
EC 3.4.24.25                Enzyme                                 
Name
vibriolysin;
Aeromonas proteolytica neutral proteinase;
aeromonolysin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Preferential cleavage of bonds with bulky hydrophobic groups in P2 and P1'. Phe at P1' is the most favoured residue, which distinguished this enzyme from thermolysin
Comment
Thermostable enzyme from Vibrio proteolyticus (formerly Aeromonas proteolytica). Specificity related to, but distinct from, those of thermolysin and bacillolysin [1]. A zinc metallopeptidase in family M4 (thermolysin family). Formerly included in EC 3.4.24.4
History
EC 3.4.24.25 created 1972 as EC 3.4.24.4, part transferred 1992 to EC 3.4.24.25, modified 1997
Orthology
K08604  vibriolysin
Genes
GKNPVT67_03015 PVT67_09445
XSASB85_15700
XTHG4Q83_21425
XAGHEP73_04011(nprV)
XASHEP74_03868(hap)
LABLA76x_2473(nprV) LA76x_2475
LAQGLA29479_1171(empA) GLA29479_1174(hap)
LCPLC55x_2887(nprV) LC55x_2889 LC55x_2891
LGULG3211_2739 LG3211_2741(nprV) LG3211_4445
LEZGLE_2741(nprV) GLE_2743(nprV)
LEMLEN_2283 LEN_2284
LMBC9I47_0200
LYTDWG18_10025
LSXH8B22_08015
LHXLYSHEL_12180
LCASLYSCAS_12180
LLZLYB30171_01014
LYARDV84_18675 RDV84_18680
THESFHQ07_05060
THEHG7079_11500
TCNH9L16_08945
TBVH9L17_11900
FSGLQ771_02990 LQ771_09765 LQ771_13930
FEDLQ772_03675 LQ772_11020 LQ772_15560
RHDR2APBS1_0936
RGLCS053_13835
RTHLRK53_06130 LRK53_12690
DTXATSB10_19710
LRZBJI69_12675
LPYFIV34_05775
LANHKR767_01775
LFLIM816_04480
LAEGL2Y94_16255
LAEOL2Y97_05845
LAESL2Y96_06360
XBAC7S18_19035
RBDALSL_0921 ALSL_2568
VCHVC_A0865
VCFIR04_03775
VCSMS6_A0903
VCEVch1786_II0554(hap)
VCQEN18_02630
VCJVCD_000466
VCIO3Y_17553
VCOVC0395_0371(hap)
VCRVC395_A0889(hap)
VCMVCM66_A0824(hap)
VCLVCLMA_B0638
VCXVAA049_2123(hap)
VCZVAB027_324(hap)
VVUVV2_0974
VVYVVA1465
VVMVVMO6_04367
VVLVV93_v1c43660(lasB)
VPAVPA0755
VPBVPBB_A0695
VPFM634_21715
VPHVPUCM_20654
VHAVIBHAR_02509 VIBHAR_05515
VCAM892_00890 M892_23945
VEXVEA_000274
VDBAL552_06510
VOWA9237_15790 A9237_19765
VROBSZ04_00415
VSPVS_1267(vsm)
VFUvfu_B00520
VANVAA_01306
LAGN175_16430
VAUVANGNB10_cII0919c(empA)
VCYIX92_04640 IX92_17695 IX92_22445
VCTJV59_17150 JV59_21375 JV59_34105
VTUIX91_16525
VEUIXK98_02965
VSIMTO69_17135
VFLAL536_05555
VMIAL543_06040
VGABSQ33_18790
VQICCZ37_14020 CCZ37_14710
VCCFAZ90_06635 FAZ90_18460
VAQFIV01_09435(hap2) FIV01_17270(nprV1) FIV01_19305(nprV2)
VSRVspart_04278(nprV)
VKABTD91_00265 BTD91_17540
VNVIF132_01670
VGIMID13_09035 MID13_15870
VSLLTQ54_15765 LTQ54_16510 LTQ54_21280
VPLSA104470976_03599(hap)
VTICEQ48_01775
VCRAIS519_00895 IS519_16885
VNPKW548_13075 KW548_18330 KW548_21875
VLEISX51_08050 ISX51_19380 ISX51_22605
VRURND59_16645
GKDK6Q96_22635 K6Q96_23505
SALYE8E00_07740 E8E00_14545
SKSFCN78_05640 FCN78_13840
SCOTHBA18_05895 HBA18_14490
SPRON7E60_06120 N7E60_16375
PAGRE2H98_08005
SDNSden_3015
SAZSama_0428 Sama_1201
SBLSbal_3874
SBMShew185_0439
SBNSbal195_0456
SBPSbal223_0465
SBTSbal678_0463
SBSSbal117_4032
SBBSbal175_0534
SHEShewmr4_2515
SHMShewmr7_2583
SHNShewana3_2681
SWDSwoo_0557 Swoo_3129
SVOSVI_2120
SHFCEQ32_07390
SPSWSps_01606 Sps_02676 Sps_03413 Sps_03524
SBJCF168_07495
SHEWCKQ84_10610 CKQ84_19125
SKHSTH12_00210(hap_1) STH12_00763(lasB) STH12_04148(hap_2)
SLITJQC75_02050 JQC75_05895
SDKKHX94_06455
SPSHFM037_17665
SYKKDN34_02045
SCYPJYB88_01960 JYB88_06140
SAVIJYB87_16680
SSEMJYB85_02135 JYB85_06435
SACHK0H61_11395
SZHK0H63_02290 K0H63_06520
SMAYK0H60_13535
SOGRA178_02405
THATH3N35_00170 H3N35_00175
TACTSG35_000160 SG35_000165 SG35_029565
TVDSG34_029320 SG34_029325 SG34_032645
PSMPSM_B0576
PIAPI2015_3586
PPHEPP2015_3255 PP2015_3842
PBWD172_014080 D172_014110 D172_019810
PRRAT705_01970 AT705_21455 AT705_23865 AT705_23895 AT705_24095
PLZS4054249_19905 S4054249_21035 S4054249_21745
PALNB0W48_01265
PPISB1L02_19675 B1L02_23455 B1L02_23510
PEAPESP_b0778
PTUPTUN_a1933 PTUN_b0532
PTDPTET_b0708
PSENPNC201_18505(empA) PNC201_22380(hap)
PDJD0907_17045
PAGAPAGA_b0882
PCARPC2016_3245
PXIJ5O05_00755 J5O05_21200
PVBJ5X90_00010 J5X90_18620 J5X90_20530 J5X90_22665 J5X90_22945 J5X90_22950
PSAZPA25_02030 PA25_34250
PFLICTT31_18695 CTT31_20005
PMAZR5H13_20175
AGZM0C34_05585
MVSMVIS_1898(empA) MVIS_2920(empA)
MYAMORIYA_1508(nprV) MORIYA_2361(nprV)
MMAAFR932_02520
MOQHWV03_05935 HWV03_07230
TTUTERTU_3351
SAGAM5M_18570
MIIBTJ40_13250 BTJ40_13270
MICTFIU95_09120(nprV)
MHYDGTQ55_10450
MICZGL2_38190
MVBMJO52_11575
MPAFR5R33_01940
LPNlpg0019
LPHLPV_0023
LPOLPO_0020
LPULPE509_03226
LPMLP6_0020
LPFlpl0020
LPPlpp0019
LPCLPC_0020
LPAlpa_00026
LPElp12_0019
LLOLLO_0045
LFALFA_0023
LSHCAB17_00130 CAB17_04525
LGTE4T54_04155
LCJNCTC11976_00699(hap)
LWASAMEA4504053_0021(hap) SAMEA4504053_0892(nprV)
LSSNCTC12082_01281(hap)
LANTTUM19329_03270
TMCLMI_0117 LMI_1381
PSALPSLF89_34
TIGTHII_0643
CYSNYP54_08535
RHHE0Z06_02880
WOCBA177_08085
HCHHCH_02479
HAHEENC22_11265 ENC22_12285
HAHHO5O45_06305
MMEMarme_2860
GSNYC6258_00785 YC6258_04970
RFOREIFOR_01115 REIFOR_01121 REIFOR_02033
PLEIQ9312_13695 Q9312_17865
AHAAHA_0851
AHYAHML_04340
AHDAI20_14990
AHRV428_04535
AHPV429_04535
AHJV469_18780
AHHRY45_04760
AHIVU14_18245
AAJBOQ57_04220
AEOO23A_p4509
AVRB565_3414
AVOAMS64_19910
AMEDB224_0573
ASRWL1483_2962(nprV)
ADHCK627_08250
ACAVVI35_03960
AEAC2U39_04290
AESC2U30_09950
AELNCTC12917_00828(nprV)
AALLI6G90_19165
AJDI6H43_07255
ARIVKYK33_16480
ASAAKXJ75_04455
AEJE5E97_08830
ABESIU367_17485
KKOKkor_0311
KGETQ33_2045
KPDCW740_01305
KAMSR900_00520
IFLC1H71_01435
CARIFNU76_01840 FNU76_12870
CKSH9L41_00435
RDPRD2015_2455
ROIN4261_15900
KIAG8A07_16855
PAQAK9V56_005565
MIUABE85_14380
JABVN23_08790
CPRACPter91_2011
UPVEJN92_01400
HOEIMCC20628_04027
BBANJ4G43_043050
DALKDSCA_47230
MXAMXAN_6106(fibA)
MSDMYSTI_02756 MYSTI_03758 MYSTI_06723
MYMA176_000783
MFBMFUL124B02_15035 MFUL124B02_35290 MFUL124B02_41125
MYXQEG98_33555
CCXCOCOR_00680(fibA1) COCOR_05260(empA) COCOR_05722(nprV) COCOR_06634(fibA)
MFULILAB_15735
MMASMYMAC_005892
AGEAA314_01740 AA314_04229 AA314_05554 AA314_07697
AVMJQX13_06230 JQX13_18330 JQX13_21325 JQX13_29500 JQX13_29505 JQX13_35000
MBDMEBOL_000619 MEBOL_004242 MEBOL_006291
CFUSCYFUS_001067 CYFUS_005706 CYFUS_006155 CYFUS_006373 CYFUS_007200 CYFUS_007262 CYFUS_007593 CYFUS_007667 CYFUS_009809
CCROCMC5_077490
UAMUABAM_00219
SCORJ3U87_04665 J3U87_18630 J3U87_25030 J3U87_34815
ZGAZOBELLIA_3906
 » show all
Reference
1  [PMID:2276]
  Authors
Holmquist B, Vallee BL.
  Title
Esterase activity of zinc neutral proteases.
  Journal
Biochemistry 15:101-7 (1976)
DOI:10.1021/bi00646a016
Reference
2  [PMID:1012006]
  Authors
Wilkes SH, Prescott JM.
  Title
Aeromonas neutral protease.
  Journal
Methods Enzymol 45:404-15 (1976)
DOI:10.1016/S0076-6879(76)45036-X
Reference
3  [PMID:7000005]
  Authors
Bayliss ME, Wilkes SH, Prescott JM.
  Title
Aeromonas neutral protease: specificity toward extended substrates.
  Journal
Arch Biochem Biophys 204:214-9 (1980)
DOI:10.1016/0003-9861(80)90026-0
Reference
4  [PMID:3123480]
  Authors
Wilkes SH, Bayliss ME, Prescott JM.
  Title
Critical ionizing groups in Aeromonas neutral protease.
  Journal
J Biol Chem 263:1821-5 (1988)
Reference
5  [PMID:1551587]
  Authors
David VA, Deutch AH, Sloma A, Pawlyk D, Ally A, Durham DR
  Title
Cloning, sequencing and expression of the gene encoding the extracellular neutral protease, vibriolysin, of Vibrio proteolyticus.
  Journal
Gene 112:107-12 (1992)
DOI:10.1016/0378-1119(92)90310-L
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.25
IUBMB Enzyme Nomenclature: 3.4.24.25
ExPASy - ENZYME nomenclature database: 3.4.24.25
BRENDA, the Enzyme Database: 3.4.24.25
CAS: 69598-88-5

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