Entry
Name
pseudolysin;
Pseudomonas elastase;
Pseudomonas aeruginosa neutral metalloproteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of proteins including elastin, collagen types III and IV, fibronectin and immunoglobulin A, generally with bulky hydrophobic group at P1'. Insulin B chain cleavage pattern identical to that of thermolysin, but specificity differs in other respects
Comment
In peptidase family M4 (thermolysin family). From the pathogenic bacteria Pseudomonas aeruginosa and Legionella pneumophila, and causes tissue damage.
History
EC 3.4.24.26 created 1972 as EC 3.4.24.4, part transferred 1992 to EC 3.4.24.26
Orthology
Genes
PAEB : NCGM1900_2552(lasB)
PAEU : BN889_04117(lasB_1)
PTW : TUM18999_56730(lasB)
LPN : lpg0467 lpg1655(lasB) lpg2977
LPH : LPV_0568(proA) LPV_1911(lasB)
LPO : LPO_0533(proA) LPO_1690(lasB) LPO_3312(lasB)
LPU : LPE509_00028 LPE509_01540 LPE509_02756
LPM : LP6_0458(proA1) LP6_1633(lasB1) LP6_3016(lasB)
LPF : lpl0508(proA) lpl1620 lpl2906
LPP : lpp0532(proA) lpp1626 lpp3049
LPC : LPC_1085(lasB) LPC_2877(proA) LPC_3292(lasB)
LPA : lpa_00713(lasB) lpa_02392(lasB) lpa_04362(lasB) lpa_04363(lasB)
LPE : lp12_0470 lp12_1593 lp12_2969
LLO : LLO_2670 LLO_2721(proA)
LCJ : NCTC11976_03280(proA)
LWA : SAMEA4504053_0770(lasB_1) SAMEA4504053_1687(lasB_2)
LSS : NCTC12082_00645(lasB_1) NCTC12082_01997(lasB_2) NCTC12082_02649(lasB_3)
LADL : NCTC12735_00425(lasB_1) NCTC12735_01661(lasB_2)
» show all
Taxonomy
Reference
1
Authors
Morihara, K. and Tsuzuki, H.
Title
Pseudomonas aeruginosa elastase: affinity chromatography and some properties as a metallo-neutral proteinase.
Journal
Agric Biol Chem 39:1123-1128 (1975)
Reference
Authors
Nishino N, Powers JC.
Title
Pseudomonas aeruginosa elastase. Development of a new substrate, inhibitors, and an affinity ligand.
Journal
J Biol Chem 255:3482-6 (1980)
Reference
Authors
Dreyfus LA, Iglewski BH.
Title
Purification and characterization of an extracellular protease of Legionella pneumophila.
Journal
Reference
Authors
Bever RA, Iglewski BH
Title
Molecular characterization and nucleotide sequence of the Pseudomonas aeruginosa elastase structural gene.
Journal
Sequence
Reference
Authors
Black WJ, Quinn FD, Tompkins LS.
Title
Legionella pneumophila zinc metalloprotease is structurally and functionally homologous to Pseudomonas aeruginosa elastase.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 3.4.24.26