Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Cleavage of His5!Leu, His10!Leu, Ala14!Leu, Tyr16!Leu and Gly23!Phe of insulin B chain; identical to the cleavage of insulin B chain by atrolysin C. Also cleaves !Ser bonds in glucagon
Comment
From the venom of the western diamondback rattlesnake (Crotalus atrox). In peptidase family M12 (astacin family)
Hemorrhagic toxins from Western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e.