adamalysin;
Crotalus adamanteus metalloendopeptidase;
proteinase I and II;
Crotalus adamanteus venom proteinase II;
adamalysin II
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Cleavage of Phe1!Val, His5!Leu, His10!Leu, Ala14!Leu, Leu15!Tyr, and Tyr16!Leu of insulin B chain
Comment
From the venom of the eastern diamondback rattlesnake (Crotalus adamanteus). Two isoenzymes of approx. 24 kDa that inactivate alpha1-proteinase inhibitor by a single cleavage. In peptidase family M12 (astacin family)