O-sialoglycoprotein endopeptidase;
glycoprotease;
glycophorin A proteinase;
glycoproteinase;
sialoglycoprotease;
sialoglycoproteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Hydrolysis of O-sialoglycoproteins; cleaves -Arg31!Asp- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated
Comment
An enzyme secreted by the bacterium Pasteurella haemolytica. Inhibited by EDTA (100 mM) and 1,10-phenanthroline. Type example of peptidase family M22