russellysin;
Russell's viper venom factor X activator;
RVV-X;
blood-coagulation factor X activating enzyme;
metalloproteinase RVV-x;
Vipera russelli proteinase;
Russell's viper blood coagulation factor X activator;
RVV-V
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Specifically activates several components of the blood clotting system, including coagulation factor X, coagulation factor IX and protein C by cleavage of -Arg! bonds. Has no action on insulin B chain
Comment
This enzyme from the venom of Russell's viper (Vipera russelli) of 79 kDa comprises a heavy (59 kDa) and a heterogeneous light (18-21 kDa) chain. Contains Ca2+ and Zn2+. The heavy chain contains the zinc-binding endopeptidase domain and a disintegrin. In peptidase family M12 (astacin family)
Activation of bovine factor IX (Christmas factor) by factor XIa (activated plasma thromboplastin antecedent) and a protease from Russell's viper venom.
Takeya H, Nishida S, Miyata T, Kawada S, Saisaka Y, Morita T, Iwanaga S
Title
Coagulation factor X activating enzyme from Russell's viper venom (RVV-X). A novel metalloproteinase with disintegrin (platelet aggregation inhibitor)-like and C-type lectin-like domains.
