KEGG ENZYME: 3.4.24.62

ENZYME: 3.4.24.62

Entry

EC 3.4.24.62                Enzyme

Name

magnolysin;
bovine neurosecretory granule protease cleaving pro-oxytocin/neurophysin;
pro-oxytocin/neurophysin convertase;
prooxyphysin proteinase;
pro-oxytocin convertase

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases

Reaction(IUBMB)

Hydrolysis of polypeptides with Arg or Lys in P1 and P2, e.g. to hydrolyse pro-oxytocin at -Lys-Arg!Ala-Val-. The specificity further depends on the organization of a beta-turn-alpha-helix of nine or more residues containing the paired basic amino acids near the centre [3]

Comment

An endopeptidase of 58 kDa known from bovine pituitary neurosecretory granules and bovine and human corpus luteum [4,5]. Inhibited by EDTA [1]

History

EC 3.4.24.62 created 1995

Reference

1 [PMID:2825769]

Authors

Clamagirand C, Creminon C, Fahy C, Boussetta H, Cohen P.

Title

Partial purification and functional properties of an endoprotease from bovine neurosecretory granules cleaving proocytocin/neurophysin peptides at the basic amino acid doublet.

Journal

Biochemistry 26:6018-23 (1987)
DOI:10.1021/bi00393a011

Reference

2 [PMID:3042797]

Authors

Creminon C, Rholam M, Boussetta H, Marrakchi N, Cohen P.

Title

Synthetic peptide substrates as models to study a pro-ocytocin/neurophysin converting enzyme.

Journal

J Chromatogr 440:439-48 (1988)
DOI:10.1016/s0021-9673(00)94547-3

Reference

3 [PMID:2674120]

Authors

Brakch N, Boussetta H, Rholam M, Cohen P.

Title

Processing endoprotease recognizes a structural feature at the cleavage site of peptide prohormones. The pro-ocytocin/neurophysin model.

Journal

J Biol Chem 264:15912-6 (1989)

Reference

4 [PMID:2659078]

Authors

Plevrakis I, Clamagirand C, Creminon C, Brakch N, Rholam M, Cohen P.

Title

Proocytocin/neurophysin convertase from bovine neurohypophysis and corpus luteum secretory granules: complete purification, structure-function relationships, and competitive inhibitor.

Journal

Biochemistry 28:2705-10 (1989)
DOI:10.1021/bi00432a051

Reference

5 [PMID:7931007]

Authors

Guillou MD, Camier M, Clamagirand C.

Title

Evidence for the presence of pro-oxytocin/neurophysin-converting enzyme in the human ovary.

Journal

J Endocrinol 142:345-52 (1994)
DOI:10.1677/joe.0.1420345

Other DBs

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