Entry
Name
choriolysin H;
teleost hatching enzyme (component);
high choriolytic enzyme (HCE)
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of the inner layer of fish egg envelope. Also hydrolysis of casein and small molecule substrates such as succinyl-Leu-Leu-Val-Tyr!7-(4-methyl)coumarylamide
Comment
Known from the teleost fish Oryzias latipes (medaka). Efficient dissolution of the egg membrane requires concerted action with choriolysin L. A 25.5 kDa peptidase in family M12 (astacin family)
History
EC 3.4.24.67 created 1995
Orthology
Genes
DRE : 407971(he1.2) 569018(he1.1) 792176(he1.3)
SRX : 107715261 107739316 107739317 107739318 107751463 107751483 107751488 107756160
SANH : 107653533 107653536 107653568 107653569 107653570 107653608 107653609 107669394 107687862 107687863 107687881 107687887 107699967
SGH : 107548229 107559407 107565490 107565491 107565492 107571701 107571702 107600986 107600988
CCAR : 109045988 109047084 109047085 109060047 109061795 109061816 109061828 109061829 109061830 109091756
CAUA : 113038526 113040175 113040180 113040182 113064352 113064641 113064804 113064806 113064807 113064808 113064809 113064810 113064811 113064812 113064813 113064816 113077243 113077245
CGIB : 127941979 127942463 127942464 127985583 127987427 127987428
PTET : 122326505 122327063 122327064 122327066 122327121 122327123 122327662 122327663 122327664 122327665 122327800
LROH : 127152840 127153608 127153721 127153722 127153723 127153724
OMC : 131528438 131529644 131529645 131530348 131530350
PPRM : 120486804(he1.3) 120486805 120486806 120486807 120486808 120494495
RKG : 130074001 130089337 130089338 130089339 130089343 130089344 130089345 130089346 130089347 130089348
MAMB : 125250914 125252131 125254227 125254236(he1.3) 125262138 125262139
CIDE : 127504241 127521101 127521102 127521103 127521104 127521105 127521106 127521107 127521109 127521110 127521111
MASI : 127428579 127428739 127438002 127438003 127438004 127438005 127438006 127438007 127438008 127438009 127438064
TROS : 130545383 130548731
TDW : 130407529 130429469 130429470 130429471 130429473 130429475 130429476 130429477
MANU : 129423088 129452669 129452675 129452676 129452677 129453517 129453518 129453593 129453595 129453713 129453714 129453715 129454011 129454012 129454017 129454018 129454242 129454243 129454244
IPU : 108259525 108259527 128629249 128629250 128629285 128629286 128629287 128629288 128629289
IFU : 128602603 128602605 128603170 128603171 128603172
SMEO : 124379750 124379924 124379925 124386720 124387887 124387889
TFD : 113649231 113649232 113649233 113649234 113649238 125139112 125145185 125145498 125145501
TVC : 132838485 132838642 132838643(he1.2) 132838645 132838646 132838647 132838648 132838649 132838651 132838657 132838671
AMEX : 111191931 111197481 111197482 111197483
CMAO : 118801682 118803789 118803790 118803792
CHAR : 105890308 105893856 105899170 105911044 105911048 105912810 116217988 116217989 116217991 116218356 116218357 116219730 116219761 116225180 122128564 122128625 122132520 122132521 122133831
TRU : 101077206 101079794 115246833 115246835 115247008 115247009 115247010 115247011 778019(fghce)
TFS : 130524187 130524188 130524214 130524698
LCO : 104919773 104927714 109137006 109141327 109141329
NCC : 104948368 104953081 104953510
TBEN : 117484276 117492057 117499386 117500185 117500186 117500271 117500272 117500273 117500275 117500276 117500277 117500281
CGOB : 115026318 115026711 115026787 115026796
PGEO : 117463910 117463980 117464014 117464050 117465902
GACU : 117557812 117557841 117557842 117557843 117557848
ELY : 117257233 117257378 117257397 117257403 117257451
EFO : 125881443 125881459 125881474 125898857 125902834
PLEP : 121940717 121942931 121958941 121959635
SLUC : 116044373 116056362 116056363 116056365 116056381 116057007 116057374 116062345
ECRA : 117944512 117948693
ESP : 116688470 116692169 116692676
PFLV : 114546703 114546744 114554616 114565874 114565876 114565877 114565878 114565879 114565880 114565881 114566058 114566059
GAT : 100190864(gahce1) 120813666 120813668 120819747 120819882 120819884
PPUG : 119212977 119213351 119220303 119220317 119221149
AFB : 129091040 129091041 129091042 129091043 129091044 129091046 129091217
CLUM : 117748581 117748589 117748590 117748591
MSAM : 119889894 119889895 119889896 119890360 119890371 119890396 119890401 119890407 119918809 119918810 119918894 119918896
SCHU : 122876857 122876868 122879978
CUD : 121509763 121509793 121509811 121509818 121509840 121509906 121524950
ALAT : 119006925 119007471 119007472 119007474 119017506 119018142 119018151 119018153 119018600 119029579
OLA : 100049314(mahce) 100049452(hceb) 100529164(hce) 101172803 105358676 111946254 111947172
OML : 112161182 112161183 112161184 112161185 112161186
CTUL : 119773600 119773610 119773611 119773612
ALIM : 106524262 106524264
AOCE : 111563322 111563324 111563328
MCEP : 125004953 125004955 125005404 125005462 125005465 125005466 125005726
CSEM : 103379239 103379240 103379241 103379289 103390327 103399268
SSEN : 122771902 122771903 122771906 122771993 122772520 122772528 122772533 122772537 122772542
HHIP : 117753222 117753227 117753241 117753251 117753261 117772120
LCF : 108890560 108897657 108897663 108897664 108897665 108897666 108897667 108897668 108897669 108897671 108897672
SDU : 111218600 111218609 111218615 111222275 111222281 111235434
SLAL : 111646196 111654950 111669431 111672327 111672329
XGL : 120790522 120790782 120790901
SSCV : 125978829 125978830
SBIA : 133509487 133509489
PTAO : 133485844 133485920
SJO : 128356110 128361028 128361044 128361050 128361060 128361073 128380597 128380697 128380893 128381161
SASA : 106564462 106588013 106588019 106588108 106589398 106597512
STRU : 115147389 115190072 115203561 115203566 115203567 115203568
OTW : 112238529 112238694 112239921
OMY : 100359379(rbhce2) 100359380(rbhce1) 110485531 110485534 110489520 110489522 110515482 110516712 118936259
OGO : 124017570 124020943 124021150 124028577 124028579 124030320 124034977 124035466 124035467 124035468
ONE : 115119423 115120296 115128072
OKI : 109880555 109885670 109885672 109886249 116352829 116359669 116359670 116372995 116375795
OKE : 118381805 118382863 127906232 127918410 127928234 127928240
SNH : 120032786 120036640 120043459
CCLU : 121548181 121548182 121554027 121557539
ELS : 105016656 105021097 105026484 106024615 114828779 114829424 114841033
AANG : 118222533 118222535 118222538 118222546 118222547 118223735 118223743 118224304 118224305 118224306
RSAN : 119377398 119390118 119390201
CSCU : 111617083 111621123 111621124 111621126 111621128 111621136 111621141 111628084 111629557 111629563 111629564 111629853
PTEP : 107441038 107441041 107441058 107441485 107446534
SDM : 118185823 118192947 118199931 118202551
HSY : 130614209 130625088 130625089 130625519 130625695 130647740
» show all
Taxonomy
Reference
Authors
Yamagami K.
Title
Isolation of a choriolytic enzyme (hatching enzyme) of the teleost, Oryzias latipes.
Journal
Reference
Authors
Yasumasu S, Iuchi I, Yamagami K.
Title
Purification and partial characterization of high choriolytic enzyme (HCE), a component of the hatching enzyme of the teleost, Oryzias latipes.
Journal
Reference
Authors
Yasumasu S, Katow S, Umino Y, Iuchi I, Yamagami K.
Title
A unique proteolytic action of HCE, a constituent protease of a fish hatching enzyme: tight binding to its natural substrate, egg envelope.
Journal
Reference
Authors
Yasumasu S, Yamada K, Akasaka K, Mitsunaga K, Iuchi I, Shimada H, Yamagami K
Title
Isolation of cDNAs for LCE and HCE, two constituent proteases of the hatching enzyme of Oryzias latipes, and concurrent expression of their mRNAs during development.
Journal
Sequence
Reference
Authors
Lee KS, Yasumasu S, Nomura K, Iuchi I.
Title
HCE, a constituent of the hatching enzymes of Oryzias latipes embryos, releases unique proline-rich polypeptides from its natural substrate, the hardened chorion.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 3.4.24.67