KEGG ENZYME: 3.4.24.7

ENZYME: 3.4.24.7

Entry

EC 3.4.24.7                 Enzyme

Name

interstitial collagenase;
vertebrate collagenase;
matrix metalloproteinase 1

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases

Reaction(IUBMB)

Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775!Ile in the alpha1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue

Comment

The enzyme takes its name from substrates of the interstitial collagen group - types I, II and III, all of which are cleaved in the helical domain. However, alpha-macroglobulins are cleaved much more rapidly. The enzyme is widely distributed in vertebrate animals. Type example of peptidase family M10

History

EC 3.4.24.7 created 1978

Orthology

K01388

matrix metalloproteinase-1 (interstitial collagenase)

Genes

HSA:	4312(MMP1)

PTR:	451510(MMP1)

PPS:	100995251(MMP1)

GGO:	101131051(MMP1)

PON:	100459931(MMP1)

NLE:	100582292(MMP1)

HMH:	116476864(MMP1)

MCC:	703653(MMP1)

MCF:	102142258(MMP1)

MTHB:

126936364

MNI:	105493708(MMP1)

CSAB:

103248335(MMP1)

CATY:

105588779(MMP1)

PANU:

101000222(MMP1)

TGE:	112607316(MMP1)

MLEU:

105542743(MMP1)

RRO:	104674665(MMP1)

RBB:	108514074(MMP1)

TFN:	117081260(MMP1)

PTEH:

111540071(MMP1)

CANG:

105500944(MMP1)

CJC:	100400727(MMP1)

SBQ:	101051246(MMP1)

CIMI:

108315434(MMP1)

CSYR:

103277141(MMP1)

MMUR:

105871610 105874564(MMP1) 105874586

LCAT:

123641886(MMP1) 123641888

PCOQ:

105822159(MMP1)

OGA:	100951906(MMP1)

MMU:	83995(Mmp1a) 83996(Mmp1b)

MCAL:

110302197 110302562

MPAH:

110327208

RNO:	300338(Mmp1b) 300339(Mmp1)

MCOC:

116072562 116072563

ANU:	117699743 117699745 117699856

MUN:

110542735

CGE:

100754854

MAUA:

101824185

PROB:

127232919

PLEU:

114708012(Mmp1)

MORG:

121451946

AAMP:

119810622

NGI:	103731579 103731678

HGL:	101697620(Mmp1)

CPOC:

100727966

CCAN:

109689286(Mmp1)

DORD:

105980664(Mmp1)

DSP:	122110407(Mmp1)

PLOP:

125348068(Mmp1)

NCAR:

124959000

MMMA:

107145904(Mmp1)

OCU:	100009110(MMP1)

OPI:	101527643(MMP1)

TUP:	102489479(MMP1) 102490608

GVR:

103610223

CFA:	489428(MMP1)

CLUD:

112671438(MMP1)

VVP:

112925907

VLG:	121500184(MMP1)

NPO:	129497337(MMP1)

AML:	100478167(MMP1) 100481181

UMR:	103662453(MMP1) 103662455

UAH:	113259797 113260135

UAR:	123792352 123792354(MMP1)

ELK:	111153766 111153845

LLV:	125078735 125078737

MPUF:

101688986(MMP1) 101689258

MNP:	132029154(MMP1) 132029164

MLK:	131834604 131834650

NVS:	122912251(MMP1) 122913961

ORO:	101369292 101371070

EJU:

114211360

ZCA:	113915492(MMP1)

MLX:

118013155

NSU:	110586222 110586384

LWW:	102733100(MMP1)

FCA:	101083957 101084217(MMP1)

PYU:	121020759 121020786

PCOO:

112865261 112865970(MMP1)

PBG:	122482471 122482878

PVIV:

125176694 125176877

LRUF:

124504840

PTG:	102951453 102970572(MMP1)

PPAD:

109257509 109257536

PUC:	125910773 125929798

AJU:

106976487

HHV:	120219691 120223090

BTA:	112441463 281308(MMP1)

BOM:	102264402(MMP1)

BIU:	109569224 109569225

BBUB:

102402661 112579733 112579734(MMP1)

BBIS:

104987807(MMP1)

CHX:	102170620(MMP1)

OAS:	101120355(MMP1)

BTAX:

128060537(MMP1)

ODA:	120876148(MMP1)

CCAD:

122449754 122450309

MBEZ:

129554246(MMP1) 129554918

SSC:	397320(MMP1)

CFR:	102517049(MMP1)

CBAI:

105067595(MMP1)

CDK:	105087169(MMP1)

VPC:	102528439(MMP1)

BACU:

103009752(MMP1)

BMUS:

118898730(MMP1)

LVE:	103089047(MMP1)

OOR:	101270980(MMP1)

DLE:	111167568(MMP1)

PCAD:

102996438(MMP1)

PSIU:

116758693(MMP1)

NASI:

112394567

ECB:	100033896(MMP1)

EPZ:	103552636(MMP1)

EAI:	106843117(MMP1)

MYB:	102253167(MMP1)

MYD:	102770236(MMP1)

MMYO:

118664460(MMP1)

MLF:	102426724 102432629

PKL:	118713253(MMP1)

EFUS:

103292965(MMP1)

MNA:	107532387(MMP1)

DRO:	112317543(MMP1)

SHON:

118975722(MMP1)

AJM:	119054054(MMP1)

PDIC:

114499949(MMP1)

PHAS:

123805463(MMP1)

MMF:	118627979(MMP1)

PPAM:

129086095(MMP1)

HAI:

109376363

RFQ:	117031217(MMP1)

PALE:

102893881(MMP1)

PVP:

105297437

RAY:	107504633(MMP1)

MJV:	108385449(MMP1)

TOD:	119240913(MMP1)

SARA:

101545391(MMP1)

LAV:	100656422(MMP1)

TMU:

101341516

ETF:	101656920 101657534

DNM:	101411093(MMP1) 101432285

MDO:	100012472(MMP1)

GAS:

123238994

SHR:	100915062(MMP1)

AFZ:

127554925

PCW:

110215019

OAA:

100078975

GGA:	418982(MMP1)

PCOC:

116230604

MGP:

100543241

CJO:

107308399

TPAI:

128074810

LMUT:

125696069

NMEL:

110389878

APLA:

101798298

ACYG:

106034204

CATA:

118245899

AFUL:

116496881

TGU:

100218575

LSR:

110470054

SCAN:

103827284

PMOA:

120506634

OTC:

121342523

PRUF:

121364174

GFR:	102045551(MMP1)

FAB:	101811360(MMP1)

OMA:

130251686

PHI:

102110938

PMAJ:

107213683

CCAE:

111924335

CCW:

104690063

CBRC:

103617951

ETL:

114067040

ZAB:

102070166

ACHL:

103805364

SVG:

106859388

MMEA:

130576284

HRT:

120748674

FPG:	101924590(MMP1)

FCH:

102051111

CLV:

102089808

EGZ:

104128912

NNI:

104023069

PCRI:

104023704

PLET:

104617131

EHS:

104508788

PCAO:

104039493

ACUN:

113477011

TALA:

104368301

PADL:

103915454

AFOR:

103895111

ACHC:

115353351

HALD:

104314247

HLE:

104828450

AGEN:

126048149

GCL:

127021511

CCRI:

104163037

CSTI:

104555988

CMAC:

104473095

MUI:

104542490

BREG:

104633768

FGA:

104081956

GSTE:

104255837

LDI:

104351210

MNB:

103774352

OHA:

104333033

NNT:

104409993

SHAB:

115603854

DPUB:

104296583

PGUU:

104468559

ACAR:

104532860

CPEA:

104390271

AVIT:

104279809

CVF:

104290312

RTD:

128901372

CUCA:

104055002

TEO:

104382376

BRHI:

104489341

AAM:

106495498

AROW:

112971957

NPD:

112943713

TGT:

104571780

DNE:

112988755

SCAM:

104151761

ASN:	102387149 102387900 102388159

AMJ:	102563438(MMP8) 102563684(MMP1) 109281824

CPOO:

109306732 109306733 109306734

GGN:	109303295 109303296 109303297

PSS:

102448178

CMY:

114018917

CCAY:

125633984

DCC:

119849729

CPIC:

101949233 101949502

TST:	117871172 117871174

CABI:

116814901

MRV:	120375402 120395357

ACS:	100552848 100553051

ASAO:

132772198

PVT:

110089072

SUND:

121927281

CTIG:

120313875

TSR:

106552779

PGUT:

117660852

APRI:

131199619

PTEX:

113440475

NSS:

113417305

VKO:

123029456

PMUA:

114595663

PRAF:

128412591

ZVI:

118084936

HCG:	128348708 128350400

GJA:

107119159

STOW:

125430822

EMC:	129325647 129326633

XLA:	108708733(mmp1.L) 495287(mmp1.S)

XTR:	594916(mmp1)

NPR:

108795960

RTEM:

120929038

BBUF:

120994012 120996396

BGAR:

122930997 122931327

MUO:

115468492

BBEL:

109462004

VEM:

105565628

HVI:

124366862

OSN:

115222658

» show all

Reference

1 [PMID:3009463]

Authors

Goldberg GI, Wilhelm SM, Kronberger A, Bauer EA, Grant GA, Eisen AZ.

Title

Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein.

Journal

J Biol Chem 261:6600-5 (1986)

Sequence

[hsa:4312]

Reference

2 [PMID:3041177]

Authors

Birkedal-Hansen H.

Title

Catabolism and turnover of collagens: collagenases.

Journal

Methods Enzymol 144:140-71 (1987)
DOI:10.1016/0076-6879(87)44177-3

Reference

3 [PMID:3032960]

Authors

Fields GB, Van Wart HE, Birkedal-Hansen H.

Title

Sequence specificity of human skin fibroblast collagenase. Evidence for the role of collagen structure in determining the collagenase cleavage site.

Journal

J Biol Chem 262:6221-6 (1987)

Reference

4 [PMID:2462561]

Authors

Sottrup-Jensen L, Birkedal-Hansen H.

Title

Human fibroblast collagenase-alpha-macroglobulin interactions. Localization of cleavage sites in the bait regions of five mammalian alpha-macroglobulins.

Journal

J Biol Chem 264:393-401 (1989)

Other DBs

ExplorEnz - The Enzyme Database:

3.4.24.7

IUBMB Enzyme Nomenclature:

3.4.24.7

ExPASy - ENZYME nomenclature database:

3.4.24.7

BRENDA, the Enzyme Database:

3.4.24.7

CAS:

9001-12-1

DBGET integrated database retrieval system