KEGG ENZYME: 3.4.24.80

ENZYME: 3.4.24.80

Entry

EC 3.4.24.80                Enzyme

Name

membrane-type matrix metalloproteinase-1;
matrix metalloproteinase 14

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases

Reaction(IUBMB)

Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at Asn37!Leu. Other bonds hydrolysed include Gly35!Ile in the propeptide of collagenase 3, and Asn341!Phe, Asp441!Leu and Gln354!Thr in the aggrecan interglobular domain

Comment

In peptidase family M10, but, unlike most members of the family, is membrane-anchored. Believed to play an important role in the activation of progelatinase A at cell surfaces.

History

EC 3.4.24.80 created 2003

Orthology

K07763

matrix metalloproteinase-14 (membrane-inserted)

Genes

HSA:	4323(MMP14)

PTR:	742887(MMP14)

PPS:	100990208(MMP14)

GGO:	101142469(MMP14)

PON:	100171646(MMP14)

NLE:	100606407(MMP14)

HMH:	116484897(MMP14)

MCC:	712429(MMP14)

MCF:	102132205(MMP14)

MTHB:

126958269

MNI:	105499628(MMP14)

CSAB:

103231446(MMP14)

CATY:

105598793(MMP14)

PANU:

101021138(MMP14)

TGE:	112629015(MMP14)

MLEU:

105547169(MMP14)

RRO:	104674133(MMP14)

RBB:	108523596(MMP14)

TFN:	117069995(MMP14)

PTEH:

111554785(MMP14)

CANG:

105503789(MMP14)

CJC:	100389088(MMP14)

SBQ:	101041075(MMP14)

CIMI:

108315352(MMP14)

CSYR:

103267686(MMP14)

MMUR:

105864715(MMP14)

LCAT:

123620578(MMP14)

PCOQ:

105814481(MMP14)

OGA:	100957810(MMP14)

MMU:	17387(Mmp14)

MCAL:

110309210(Mmp14)

MPAH:

110325048(Mmp14)

RNO:	81707(Mmp14)

MCOC:

116084514(Mmp14)

ANU:	117705214(Mmp14)

MUN:	110550039(Mmp14)

CGE:	100689336(Mmp14)

MAUA:

101828511(Mmp14)

PROB:

127230416(Mmp14)

PLEU:

114708709(Mmp14)

MORG:

121435038(Mmp14)

MFOT:

126490920

AAMP:

119800000(Mmp14)

NGI:	103739479(Mmp14)

HGL:	101723795(Mmp14)

CPOC:

100732039(Mmp14)

CCAN:

109685808(Mmp14) 109689717

DORD:

105992545(Mmp14)

DSP:	122113480(Mmp14)

PLOP:

125363479(Mmp14)

NCAR:

124974865

MMMA:

107148235(Mmp14)

OCU:	100009598(MMP14)

OPI:	101516419(MMP14)

TUP:	102468813(MMP14)

GVR:	103585554(MMP14)

CFA:	403823(MMP14)

CLUD:

112657051(MMP14)

VVP:	112926491(MMP14)

VLG:	121493160(MMP14)

NPO:	129499441(MMP14)

AML:	100468621(MMP14)

UMR:	103681059(MMP14)

UAH:	113246072(MMP14)

UAR:	123795799(MMP14)

ELK:

111158421

LLV:

125104089

MPUF:

101689912(MMP14)

MNP:	131999791(MMP14)

MLK:	131836341(MMP14)

NVS:	122893172(MMP14)

ORO:	101369821(MMP14)

EJU:	114217869(MMP14)

ZCA:	113909394(MMP14)

MLX:	118003628(MMP14)

NSU:	110585608(MMP14)

LWW:	102730388(MMP14)

FCA:	101089776(MMP14)

PYU:	121031488(MMP14)

PCOO:

112855695(MMP14)

PBG:	122468871(MMP14)

PVIV:

125168909(MMP14)

LRUF:

124508807

PTG:	102953674(MMP14)

PPAD:

109255047(MMP14)

PUC:

125909706

AJU:

106988210

HHV:	120240441(MMP14)

BTA:	281915(MMP14)

BOM:	102281987(MMP14)

BIU:	109564819(MMP14)

BBUB:

102413520(MMP14)

BBIS:

104981988(MMP14)

CHX:	100861171(MMP14)

OAS:	443116(MMP14)

BTAX:

128053747(MMP14)

ODA:	120853412(MMP14)

CCAD:

122443218(MMP14)

MBEZ:

129562985(MMP14)

SSC:	397471(MMP14)

CFR:	102513570(MMP14)

CBAI:

105068764(MMP14)

CDK:	105096970(MMP14)

VPC:	102525752(MMP14)

BACU:

103003307(MMP14)

BMUS:

118890456(MMP14)

LVE:	103081188(MMP14)

OOR:	101284790(MMP14)

DLE:	111164185(MMP14)

PCAD:

102987825(MMP14)

PSIU:

116748985(MMP14)

NASI:

112397473(MMP14)

ECB:	100034170(MMP14)

EPZ:	103556751(MMP14)

EAI:	106840662(MMP14)

MYB:	102240202(MMP14)

MYD:	102761559(MMP14)

MMYO:

118679356(MMP14)

MLF:	102431406(MMP14)

PKL:	118724917(MMP14)

EFUS:

103301531(MMP14)

MNA:	107531691(MMP14)

DRO:	112301504(MMP14)

SHON:

118980961(MMP14)

AJM:	119037284(MMP14)

PDIC:

114491682(MMP14)

PHAS:

123820486(MMP14)

MMF:	118616019(MMP14)

PPAM:

129074125(MMP14)

HAI:	109393698(MMP14)

RFQ:	117024113(MMP14)

PALE:

102887003(MMP14)

PGIG:

120593901(MMP14)

PVP:	105300520(MMP14)

RAY:	107498042(MMP14)

MJV:	108400026(MMP14)

TOD:	119238905(MMP14)

SARA:

101551659(MMP14)

LAV:	100671131(MMP14)

TMU:

101345768

ETF:	101656746(MMP14)

DNM:	101420058(MMP14)

MDO:	100030382(MMP14)

GAS:	123236026(MMP14)

SHR:	100932143(MMP14)

AFZ:

127551035

PCW:	110223023(MMP14)

OAA:	100091029(MMP14)

LSR:

110481924

PMOA:

120512485

PHI:	102107021(MMP14)

AGEN:

126037221

ASN:	102368749(MMP14)

AMJ:	102558609(MMP14)

CMY:	102943947(MMP14)

CCAY:

125622589(MMP14)

DCC:	119841791(MMP14)

CPIC:

101945719(MMP14)

CABI:

116818422(MMP14)

MRV:	120380346(MMP14)

ACS:	100553534(mmp14)

ASAO:

132777648(MMP14)

PVT:	110087815(MMP14)

SUND:

121934813(MMP14)

PBI:	103064383(MMP14)

PMUR:

107295092(MMP14)

CTIG:

120317985(MMP14)

TSR:	106550394(MMP14)

PGUT:

117658208(MMP14)

APRI:

131197583(MMP14)

PTEX:

113448731(MMP14) 113451750

NSS:	113422251(MMP14) 113427188

VKO:	123018636(MMP14)

PMUA:

114581663(MMP14)

PRAF:

128399506(MMP14)

ZVI:	118095008(MMP14)

HCG:	128329770(MMP14)

GJA:	107109121(MMP14)

EMC:	129338762(MMP14)

XLA:	108707025 407753(mmp14.L)

XTR:	594950(mmp14)

NPR:	108786770(MMP14)

RTEM:

120941067(MMP14)

BBUF:

120989035(MMP14)

BGAR:

122923469(MMP14)

MUO:	115456955(MMP14)

GSH:	117350258(MMP14)

DRE:	373882(mmp14a) 566945(mmp14b)

SRX:	107706348 107738136 107753930

SANH:

107668983 107669100 107691938 107704286

SGH:	107557973 107562471(mmp14) 107588203 107591383

CCAR:

109060080 109064679 109111707 109111713

CAUA:

113044985 113052124 113052125 113105708 113119884

CGIB:

127933340 127951000 127962211 128017137

PTET:

122323463(mmp14b) 122349364(mmp14a)

LROH:

127168695(mmp14a) 127182330(mmp14b)

OMC:	131520650(mmp14b) 131544302(mmp14a)

PPRM:

120462605(mmp14a) 120465105(mmp14b)

RKG:	130076154(mmp14b) 130102601(mmp14a)

MAMB:

125251639(mmp14b) 125264498(mmp14a)

CIDE:

127494064 127515365

MASI:

127412145 127440633 127442247 127445441

TROS:

130553967(mmp14a) 130554170(mmp14b)

TDW:	130417209(mmp14b) 130428394(mmp14a)

MANU:

129440312(mmp14a) 129441835(mmp14b)

IPU:	108267832 108267934(mmp14a)

IFU:	128609516(mmp14b) 128610251(mmp14a)

PHYP:

113525614 113540329

SMEO:

124386873(mmp14b) 124387269(mmp14a)

TFD:	113633887(mmp14b) 113663174(mmp14a)

TVC:	132848324(mmp14b) 132848843(mmp14a)

AMEX:

103024760(mmp14) 103041213

CMAO:

118825668(mmp14a) 118825730(mmp14b)

EEE:	113578328 113589197(mmp14)

CHAR:

105895553(mmp14a) 105907068(mmp14b)

TRU:	101061607 101073560

TFS:	130522245(mmp14a) 130539565(mmp14b)

TNG:	GSTEN00015140G001 GSTEN00025878G001

LCO:	104927972 104932902

NCC:	104952609 104956583

TBEN:

117488121(mmp14a) 117488510(mmp14b)

CGOB:

115022907 115023741

PGEO:

117462031(mmp14b) 117463873(mmp14a)

GACU:

117539229(mmp14a) 117556619(mmp14b)

EMAC:

134865988(mmp14b) 134872261(mmp14a)

ELY:	117246202(mmp14a) 117272256(mmp14b)

EFO:	125883715(mmp14a) 125901619(mmp14b)

PLEP:

121952037(mmp14b) 121961947(mmp14a)

SLUC:

116043318(mmp14a) 116055111(mmp14b)

ECRA:

117934665(mmp14a) 117954333(mmp14b)

ESP:	116684895 116699164 116707003

PFLV:

114545892(mmp14) 114565145

GAT:	120816303(mmp14b) 120821932(mmp14a)

PPUG:

119209171(mmp14b) 119222503(mmp14a)

AFB:	129088883(mmp14b) 129093101(mmp14a)

CLUM:

117746697(mmp14b) 117747783(mmp14a)

PSWI:

130197928(mmp14b) 130211969(mmp14a)

MSAM:

119902498(mmp14b) 119912139(mmp14a)

SCHU:

122869956(mmp14a) 122887183(mmp14b)

CUD:	121504664(mmp14a) 121520493(mmp14b)

ALAT:

119011743(mmp14b) 119027665(mmp14a)

MZE:	101464934 101486213

ONL:	100691693 100695964

OAU:	116312338(mmp14a) 116333767(mmp14b)

OLA:	100125428(mmp14) 101171699

OML:	112147164(mmp14b) 112156455(mmp14a)

CSAI:

133420119(mmp14a) 133452983(mmp14b)

XMA:	102236291 102236856

XCO:	114146537 114157472

XHE:	116721687 116732222

PRET:

103475992 103478877

PFOR:

103138402 103145985(mmp14)

PLAI:

106934757 106944750

PMEI:

106918840(mmp14) 106926970

GAF:	122820067(mmp14a) 122840722(mmp14b)

PPRL:

129362045(mmp14b) 129379472(mmp14a)

CVG:	107087725 107101469(mmp14)

CTUL:

119773355(mmp14a) 119793328(mmp14b)

GMU:	124870019(mmp14b) 124881091(mmp14a)

NFU:	107377284(mmp14) 107384247

KMR:	108238671(mmp14b) 108245890(mmp14a)

ALIM:

106517892 106526432 106535469

NWH:	119408978(mmp14a) 119414992(mmp14b)

AOCE:

111577984 111587803

MCEP:

125010467(mmp14b) 125022045(mmp14a)

CSEM:

103388226(mmp14) 103396588

POV:	109640512 109641241

SSEN:

122766893(mmp14a) 122778576(mmp14b)

HHIP:

117778918(mmp14b) 117779297(mmp14a)

HSP:	118102417(mmp14a) 118117847(mmp14b)

SMAU:

118287780(mmp14a) 118310471(mmp14b)

LCF:	108883931(mmp14b) 108903045(mmp14a)

SDU:	111223843 111235670

SLAL:

111647186 111666536

XGL:	120797566(mmp14a) 120799114(mmp14b)

HCQ:	109508489 109512811

SSCV:

125973364 125984530

SBIA:

133494704(mmp14a) 133510391(mmp14b)

PEE:	133397616(mmp14a) 133411425(mmp14b)

PTAO:

133472402(mmp14a) 133489369(mmp14b)

BPEC:

110170349 110172013

MALB:

109962674 109974431

BSPL:

114844813(mmp14b) 114850074(mmp14a)

SJO:	128369257(mmp14b) 128384020(mmp14a)

SASA:

106569443 106577791 106600280 106608848

STRU:

115157316 115169490 115194394 115198396

OTW:	112214636(mmp14a) 112226707 112235598 112260764

OMY:	110500495(mmp14a) 110508483(mmp14b) 110530599 110531636

OGO:	124008505 124009973 124014257 124041589(mmp14b)

ONE:	115102780 115114675 115133442 115137978

OKI:	109871780 109875099 109896970 109906435

OKE:	118368870 118392084(mmp14a) 118394992(mmp14b) 118401873

SALP:

111953232 111956641 111979299 112080231

SNH:	120020209 120030301 120049716 120055633

CCLU:

121535634 121572618 121581129(mmp14b) 123482924

ELS:	105020567 105021572

SFM:	108930930 108937864(mmp14) 114911942

PKI:	111837704 111854546

AANG:

118234064(mmp14b)

PSPA:

121305269 121306845

ARUT:

117398173(mmp14b)

PSEX:

120524476

LCM:	102355301(MMP14)

LERI:

129716140

PMRN:

116946025

LRJ:

133340387

BFO:	118403865 118405991 118406077 118407203 118407405 118407406 118410626 118416517 118418696 118422022 118426409 118431106

BBEL:

109462286 109465428 109467309 109468271 109468435 109474289 109479373 109480028 109480908 109486532

CIN:	100175506 100181633 100184312

SCLV:

120329469 120332934

SPU:	105436437 105439065 105441790 115919166 115921774 115923431 115924100 115924102 576018 576145 581157 581457 582797(MMP14) 583799 585680 592649 752715

LPIC:

129254576 129262185 129273667 129275862 129275958 129276242 129281158 129281296 129281756 129281797 129281986

APLC:

110981585 110981864 110982266 110986275 110986843 110986844 110986855 110986884 110990105

AJC:	117109985 117110040 117110050 117124559 117124573

SKO:	100369238 100369384 100373845 100373999 100377895 100378191

DME:	Dmel_CG4859(Mmp1) Dmel_CG7056(HHEX)

DER:	6548508 6553563

DSE:

6618866

DSI:	Dsimw501_GD20010(Dsim_GD20010) Dsimw501_GD24926(Dsim_GD24926)

DYA:	Dyak_GE11424

DAN:

6494770

DSR:

110182794

DPO:

4805299

DPE:

6592953

DMN:	108160136 117185778

DWI:

6640267

DGR:	6560466 6563713

DMO:	Dmoj_GI19538

DAZ:

108616549

DNV:

108654324

DHE:

111593840

DVI:

6625046

CCAT:

101460552 101461412

BOD:	106622068 106627693

BDR:	105230249 105230978

RZE:	108363354 108372064

AOQ:	129235386 129243716

TDA:	119675513 119679599

MDE:

101888990

SCAC:

106082756 106086034

LCQ:

111679245

LSQ:	119606779 119608562 119614438 119615725

GFS:

119642247

ECOE:

129952208

CLON:

129611244

HIS:

119646152

AGA:

1270173

ACOZ:

120947394

AARA:

120897383 120905478

AMER:

121592038

ASTE:

118506494 118512669

AFUN:

125771541

AMOU:

128300470

AALI:

118463173

AAG:	5566822 5575548 5575549 5575550 5575574

AALB:

109410819 109410820 109410823 109421170 109421241 109421242 109425677 115256248 115256255 115256256 115256258 115266864 115266868 115266869

CQU:	CpipJ_CPIJ010856 CpipJ_CPIJ012497 CpipJ_CPIJ015719 CpipJ_CPIJ016690 CpipJ_CPIJ016691 CpipJ_CPIJ016692

CPII:

120414643 120414880 120421278 120421289 120421290 120421291

CNS:

116338916

BCOO:

119069679 119081749

ACER:

107993310

ALAB:

122710880

ADR:

102671973

AFLR:

100869155

BIM:

100741313

BBIF:

117212916

BVK:

117233695

BVAN:

117158980

BTER:

100647268

BAFF:

126926503

BPYO:

122571303

BPAS:

132908850

FVI:

122534048

CCAL:

108628386

OBB:

114880439

OLG:	117608294 117608429

MGEN:

117217405

NMEA:

116426310

CGIG:

122400960 122402161

SOC:	105198300 105205971

MPHA:

105835181 105835693

AEC:

105151121

ACEP:

105619997

PBAR:

105422417 105424243 105424383 105426446

VEM:

105566274

HST:

105190364

DQU:	106744935 106748962

CFO:

105255413

FEX:

115241861

LHU:

105675698

PGC:	109858212 109861586 109861889 109861992 109862219 109863338

OBO:

105286124

PCF:

106788603

PFUC:

122522006

VPS:

122636559

VCRB:

124432304

VVE:

124956498

NVI:	100113893(Mmp1)

CSOL:

105368158

TPRE:

106651404

LHT:

122502870

LBD:

127282597

MDL:

103577460

CGLO:

123263452

FAS:

105271342

DAM:

107036851

AGIF:

122847785 122860917

CINS:

118074355

VCAN:

122417944

CCIN:

107268792 107270395 107272043

DSM:	124404461 124410561

NPT:

124210989

NFB:

124174691

NLO:

107223958

NVG:

124296925

AROA:

105683294

TCA:	103313084 103313085 657261(Mmp-1)

DPA:

109542402

SOY:

115889561

AGRG:

126740476

ATD:

109596135

CSET:

123311328 123312265 123312267

AGB:	108910021 108910921

LDC:	111512850 111512852

NVL:	108563139 108563140 108566081

APLN:

108741148 112904568

PPYR:

116163807 116172083 116172517 116182295

OTU:	111415936 111417845 111424932

BMOR:

100144547(Mmp1)

BMAN:

114249403

MSEX:

115445748 119191609 119193430

DPL:	KGM_204463

BANY:

112043322

MJU:

123864465

NIQ:

126775635

VCD:

124536044

MCIX:

123664994

PMAC:

106712426

PPOT:

106107829

PXU:

106116917

PRAP:

111002882

PBX:

123707644

PNAP:

125055885 125056289

ZCE:	119830077 119830092 119830249

CCRC:

123699336

LSIN:

126971371

HAW:

110371693

HZE:

124637345

TNL:

113492652

SLIU:

111353141

OFU:

114356670

PXY:

105396373

PGW:

126381824

CFEL:

113370190 113371077 113374433

CCRN:

123305758

API:

100164006

DNX:

107166270

AGS:	114124803 114124805

RMD:

113560497

ACOO:

126840413 126841334 126841381

DVT:	126904256 126908124 126908125 126908127 126908128

BTAB:

109040286

DCI:

103519571

CLEC:

106669674

HHAL:

106677886 106677898 106677916 106691851

NLU:	111057664 111058731

HVI:

124359559

MQU:	128991305 128991307 128992215 128992550 128998645

PHU:	Phum_PHUM302710

FOC:

113213791

TPAL:

117643377

ZNE:	110834801 110834804 110840851

CSEC:

111865495 111865497 111866716 111866774

SGRE:

126336836

BROR:

134532171

IEL:	124154986 124161113

FCD:	110860548 110860649 110860650 110860652 110860657

DPX:	DAPPUDRAFT_229419 DAPPUDRAFT_303785 DAPPUDRAFT_325672 DAPPUDRAFT_325673

DMK:

116916797

DPZ:	124314058 124316241

PVM:

113820224

PJA:

122257686

PCHN:

125032121 125038978

PMOO:

119596927

HAME:

121869479 121869561

PCLA:

123744861 123744862 123759852

CQD:	128684114 128706577

PTRU:

123501683

ESN:

127005132

HAZT:

108667780

EAF:	111699680 111708257 111710507

LSM:	121129741 121130249

TCF:	131878984 131879453 131879972

PPOI:

119097459 119097462 119109535 119109675

DSV:

119443090

RSAN:

119388217

RMP:

119185118

VDE:

111254153

VJA:

111271735

TUT:

107367240

DPTE:

113799701

DFR:

124494264

CSCU:

111636483

PTEP:

107450087 107450091

ABRU:

129960348 129963441

UDV:	129219355 129219910 129235214

SDM:	118183209 118205650

LPOL:

106461522 106467071 106469092

PMEO:

129593539 129593831 129593890 129594261 129595739

HRO:	HELRODRAFT_108967 HELRODRAFT_193602 HELRODRAFT_193603

LGI:	LOTGIDRAFT_158923 LOTGIDRAFT_160600 LOTGIDRAFT_200320 LOTGIDRAFT_231475

PVUL:

126821564

PCAN:

112555453 112562988

BGT:	106051365 106074476

GAE:	121367749 121376669

HRF:	124112473 124113799 124116437 124116459 124120008

HRJ:	124253143 124256263 124261822 124277101

CRG:	105319539 105333479

CVN:	111099717 111137713 111138285

CANU:

128161283 128180086

OED:	125647353 125659971 125659972 125664093

MYI:	110455345 110459519 110462871

PMAX:

117342186

MCAF:

127737545

MMER:

123533194 123554940

RPHI:

132726857 132740098

DPOL:

127834476

OBI:	106869299 106873152 106876107 106879964

OSN:	115209377 115224271 115230377

LAK:	106152579 106152606 106155462 106156796 106163428 106164145 106168179

NVE:	5500606 5506166 5509262 5510262 5510263 5512892 5520492 5520493

EPA:	110231292 110238012 110238646 110239804 110251669 110254069

ATEN:

116286904 116289580 116302034 116302824

ADF:	107349768 107349780

AMIL:

114963032 114966306 114966308

PDAM:

113669026 113674901 113674903 113678590 113679792 113684651 113684653 113685983

SPIS:

111324455 111324555 111324941 111324943 111324944 111324945 111324968 111342087

DGT:	114517718 114522163 114542131

XEN:	124434705 124441150 124441151 124457226

HMG:	100199631 100200849 100200988 100201138 100201778 100202503 100204953 101234798 101239608 101241586 105843571

HSY:	130612801 130625523

» show all

Reference

1 [PMID:11532942]

Authors

Itoh Y, Takamura A, Ito N, Maru Y, Sato H, Suenaga N, Aoki T, Seiki M.

Title

Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion.

Journal

EMBO J 20:4782-93 (2001)
DOI:10.1093/emboj/20.17.4782

Other DBs

ExplorEnz - The Enzyme Database:

3.4.24.80

IUBMB Enzyme Nomenclature:

3.4.24.80

ExPASy - ENZYME nomenclature database:

3.4.24.80

BRENDA, the Enzyme Database:

3.4.24.80

CAS:	161384-17-4

DBGET integrated database retrieval system