Entry
Name
ADAM10 endopeptidase;
Kuzbanian protein;
myelin-associated disintegrin metalloproteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Endopeptidase of broad specificity
Comment
In peptidase family M12. Partially responsible for the "alpha-secretase" activity in brain that degrades the potentially harmful beta-amyloid peptide. Work with ADAM10-deficient mice supports a role in Notch signalling.
History
EC 3.4.24.81 created 2003
Orthology
K06704 disintegrin and metalloproteinase domain-containing protein 10
Genes
PANU : 101023521 116275816(ADAM10)
MDO : 100024929 100027329(ADAM10)
GAS : 123232128 123238019(ADAM10)
SHR : 100913194(ADAM10) 100925760
PCW : 110197392 110205292(ADAM10)
OAA : 100074755(ADAM10) 114806495
AMJ : 102562482 102563250(ADAM10)
CPOO : 109308972(ADAM10) 109320461
GGN : 109288646(ADAM10) 109294893
PSS : 102444574(ADAM10) 102461827
CMY : 102936468 102944138(ADAM10)
CCAY : 125627339 125643537(ADAM10)
DCC : 119848522 119862424(ADAM10)
CPIC : 101948731 101953463
TST : 117868878 117883650(ADAM10)
CABI : 116821168(ADAM10) 116838433
MRV : 120373604(ADAM10) 120391577
PVT : 110074537(ADAM10) 110079237
SUND : 121932590(ADAM10) 121936559
PBI : 103053091 103062263(ADAM10)
CTIG : 120297076 120306557(ADAM10)
PGUT : 117660950(ADAM10) 117668650
APRI : 131184515(ADAM10) 131188358
PMUA : 114583918(ADAM10) 114588574
PRAF : 128401348(ADAM10) 128405612
ZVI : 118086073 118093232(ADAM10)
HCG : 128334968(ADAM10) 128343475
XLA : 108706832 108711361 399187(adam10.S)
XTR : 100491788 733451(adam10)
NPR : 108789826(ADAM10) 108796952
RTEM : 120924706 120931382(ADAM10)
BBUF : 120985758(ADAM10) 120989514
BGAR : 122919690 122927656(ADAM10)
MUO : 115458968(ADAM10) 115480953
GSH : 117348352(ADAM10) 117365650
DRE : 393392(adam10b) 560975(si:ch1073-396h14.1) 566044(adam10a)
SRX : 107706850 107715085 107741424 107750500
SANH : 107653620 107670741 107687609 107700430 107704208
SGH : 107552424 107561888 107574154 107585986 107588113 107595097
CCAR : 109050964 109062319 109087040 109087041 109109603 109113683
CAUA : 113040149 113040165 113042957 113042958 113051523 113051912 113067144 113105935
CGIB : 127947390 127961248 127987059(si:ch1073-396h14.1) 128014654 128016971
PTET : 122327702(si:ch1073-396h14.1) 122330937 122348925(adam10a)
LROH : 127153704(si:ch1073-396h14.1) 127156647 127168228(adam10a)
OMC : 131529654(si:ch1073-396h14.1) 131534697 131544062(adam10a)
PPRM : 120474036 120486226(si:ch1073-396h14.1) 120491441(adam10a)
RKG : 130069931(adam10a) 130070840 130089312(si:ch1073-396h14.1)
MAMB : 125246761 125251118(si:ch1073-396h14.1) 125261896(adam10b) 125264716(adam10a)
CIDE : 127494308 127515451 127520833(si:ch1073-396h14.1)
MASI : 127409612 127436233 127437623 127439042(si:ch1073-396h14.1) 127447476
TROS : 130548346(si:ch1073-396h14.1) 130551632 130554878(adam10a)
TDW : 130413805 130423549(adam10a) 130429637(si:ch1073-396h14.1)
MANU : 129434287 129442645 129442798(adam10a) 129452754(si:ch1073-396h14.1)
IPU : 108259300(adam10a) 108271130(si:ch1073-396h14.1) 108275251
IFU : 128603054(adam10a) 128613918(si:ch1073-396h14.1) 128618398
PHYP : 113530072 113536691 113540838(adam10)
SMEO : 124379666(adam10a) 124391425(si:ch1073-396h14.1) 124392002
TFD : 113636788(adam10a) 113639154 113644300(si:ch1073-396h14.1)
TVC : 132838517(adam10a) 132854365(si:ch1073-396h14.1) 132856603
AMEX : 103027184 103041829 103043423
CMAO : 118811815 118817577(adam10a) 118819356(si:ch1073-396h14.1)
EEE : 113571849 113574487 113575694(adam10)
CHAR : 105892433 105893023(adam10a) 122132156
TRU : 101068415 101072781 101078173(adam10)
TFS : 130521853(adam10a) 130528581(si:ch1073-396h14.1) 130535896
TNG : GSTEN00017721G001 GSTEN00025611G001 GSTEN00028800G001
LCO : 104924306(adam10) 104931412 109138148
NCC : 104960057(adam10) 104960084
TBEN : 117471295(adam10a) 117491647 117495638(si:ch1073-396h14.1)
CGOB : 115007325 115009702 115025305(adam10)
PGEO : 117445636(si:ch1073-396h14.1) 117448005 117467957(adam10a)
GACU : 117533264(adam10a) 117538862 117541131(si:ch1073-396h14.1)
EMAC : 134863302(adam10a) 134869801(si:ch1073-396h14.1) 134875897
ELY : 117252642(adam10a) 117253616(si:ch1073-396h14.1) 117262371
EFO : 125887242 125895492(si:ch1073-396h14.1) 125899756(adam10a)
PLEP : 121937813(si:ch1073-396h14.1) 121947514(adam10a) 121950293
SLUC : 116038274 116055227(si:ch1073-396h14.1) 116060685(adam10a)
ECRA : 117949631 117951000(si:ch1073-396h14.1) 117958595(adam10a)
ESP : 116691941(adam10) 116693868 116695127
PFLV : 114560197 114561555 114571794(adam10)
GAT : 120809559 120812703 120824183(si:ch1073-396h14.1) 120831617(adam10a)
PPUG : 119195954 119216355(si:ch1073-396h14.1) 119228370(adam10a)
AFB : 129095060(si:ch1073-396h14.1) 129102437(adam10a) 129108039
CLUM : 117730193(si:ch1073-396h14.1) 117731989 117747927(adam10a)
PSWI : 130192162(adam10a) 130193741(si:ch1073-396h14.1) 130195476
MSAM : 119890154(adam10a) 119893471 119900750(si:ch1073-396h14.1)
SCHU : 122874550 122877697(si:ch1073-396h14.1) 122878274(adam10a)
CUD : 121508420(adam10a) 121512543(si:ch1073-396h14.1) 121514982
ALAT : 119017915(adam10a) 119023933 119028768(si:ch1073-396h14.1)
MZE : 101468342(adam10) 101469610 101471777
ONL : 100695735 100707598 100710655(adam10)
OAU : 116309232(si:ch1073-396h14.1) 116326736 116334631(adam10a)
OLA : 101155340(adam10) 101159183 101172489
OML : 112150653(si:ch1073-396h14.1) 112152362 112160714(adam10a)
CSAI : 133444111 133458380(si:ch1073-396h14.1) 133462338(adam10a)
XMA : 102230569(adam10) 102232731 102235509
XCO : 114142909(adam10) 114150800 114160272
XHE : 116718526(adam10) 116725567 116735620
PRET : 103462514(adam10) 103463533 103466445
PFOR : 103129915 103155695 103156888
PLAI : 106955286 106958140 106958532
PMEI : 106907089 106919346 106928916
GAF : 122835335 122838502(si:ch1073-396h14.1) 122843708(adam10a)
PPRL : 129359322 129364056(adam10a) 129374594(si:ch1073-396h14.1)
CVG : 107087405 107095645(adam10) 107097307
CTUL : 119775039 119780852(si:ch1073-396h14.1) 119795460(adam10a)
GMU : 124866912(adam10a) 124873924(si:ch1073-396h14.1) 124880736
NFU : 107381374(adam10) 107388626 107393171
KMR : 108230196 108230826(si:ch1073-396h14.1) 108251752(adam10a)
ALIM : 106521566 106526819 106531660(adam10)
NWH : 119407429(si:ch1073-396h14.1) 119416346 119422316(adam10a)
AOCE : 111577572(adam10) 111577716 111578412 111586567
MCEP : 125005094(adam10a) 125008901 125014792
CSEM : 103378728(adam10) 103380473 103397216
POV : 109624447 109625416 109636872(adam10)
SSEN : 122760920 122761376 122780907(si:ch1073-396h14.1)
HHIP : 117756608(adam10a) 117760656(si:ch1073-396h14.1) 117763808
HSP : 118106022(adam10a) 118109680 118121612(si:ch1073-396h14.1)
SMAU : 118302927(adam10a) 118314718 118318520(si:ch1073-396h14.1)
LCF : 108876711 108881395(si:ch1073-396h14.1) 108887706(adam10a)
SDU : 111221439(adam10) 111229691 111232234
SLAL : 111654257 111655135(adam10) 111666982
XGL : 120789059(adam10a) 120790937(si:ch1073-396h14.1) 120793207
HCQ : 109507576 109525931(adam10) 109532053
SSCV : 125967675 125970101 125973800(si:ch1073-396h14.1)
SBIA : 133497851(adam10a) 133502181 133503448(si:ch1073-396h14.1)
PEE : 133399245(adam10a) 133402433 133406220(si:ch1073-396h14.1)
PTAO : 133468637(adam10a) 133478558 133481407(si:ch1073-396h14.1)
BPEC : 110160182 110169553 110175225(adam10)
MALB : 109963286(adam10) 109967440 109973882
BSPL : 114852731(adam10a) 114853516(si:ch1073-396h14.1) 114857455
SJO : 128359316 128360136(adam10a) 128362031(si:ch1073-396h14.1)
SASA : 106561772 106561774 106562201(adam10) 106573543 106584732 106587342
STRU : 115151751 115167240 115192885 115197708 115203098
OTW : 112219062 112249184 112252197(si:ch1073-396h14.1) 112263716(adam10a) 112265333
OMY : 110501717(si:ch1073-396h14.1) 110502564 110521213 110526414(adam10a) 118944511
OGO : 123998865(si:ch1073-396h14.1) 124031711 124033743 124035726 124037494
ONE : 115109210 115112270 115113653 115124074 115144664
OKI : 109876107 109887842 109888613 109895382 109897681
OKE : 118359506(adam10a) 118373228 118375110(si:ch1073-396h14.1) 118377547 118393877
SALP : 111952855 111969384 111973806 112068468
SNH : 120025369 120036120 120047253 120052330 120053169(si:ch1073-396h14.1) 120066766
CCLU : 121540691 121558909 121568068 121576809 123485820
ELS : 105011472 105016508(adam10) 105018354
SFM : 108919823 108926731(adam10) 108931162
PKI : 111845001 111846754 111860388
AANG : 118215630 118225832(si:ch1073-396h14.1) 118227666
LOC : 102689715(adam10) 102693175
PSPA : 121294484 121299163 121300696(si:ch1073-396h14.1)
ARUT : 117401274 117429900 117963203(adam10a) 117966367
PSEX : 120537804(si:ch1073-396h14.1) 120539900(adam10a)
LCM : 102349523 102351415(ADAM10)
CMK : 103183500(si:ch1073-396h14.1) 103189371(adam10a)
HOC : 132828850 132834284(adam10a)
LERI : 129711215(si:ch1073-396h14.1) 129712636(adam10a)
PMRN : 116937372 116950624 116953601 116954876
LRJ : 133341406 133346567 133354180 133355124
BFO : 118411340 118411919 118412071 118412678
BBEL : 109468335 109468471 109468715 109468796
SPU : 115918272 115919534 581388 755122
APLC : 110979325 110989644 110989645
SKO : 100313545(Adam10) 100366937 100367090 100367238 102807735
DME : Dmel_CG1964(Kul) Dmel_CG7147(kuz)
DSI : Dsimw501_GD15481(Dsim_GD15481) Dsimw501_GD21457(Dsim_GD21457)
DYA : Dyak_GE18670 Dyak_GE23876
DMO : Dmoj_GI10418 Dmoj_GI17667
RZE : 108361935 108372162 108372853 108375029 108381691
TDA : 119663047 119667420 119676898 119687179
MDE : 101888784 101900641 131801326
SCAC : 106082815 106089926
ECOE : 129940919 129942202
CLON : 129606026 129612138
ACOZ : 120948706 120955312 120960899
AARA : 120898114 120899748
AMER : 121589429 121598094
ASTE : 118505437 118511695
AFUN : 125760454 125763785
AMOU : 128301286 128305951
AALB : 109410817 109621728 115256260
CQU : CpipJ_CPIJ016694 CpipJ_CPIJ017248
CPII : 120421296 120424630
BCOO : 119070042 119071547
AME : 409611 409692 410609
ACER : 107994235 108000950 108001185
ALAB : 122712815 122712908 122719607
ADR : 102670923 102672303 102681224
AFLR : 100866886 100868097 100869852
BIM : 100743906 100745330 100746737
BBIF : 117208929 117209893 117216802
BVK : 117230491 117230827 117235321
BVAN : 117160523 117164369 117166445
BTER : 100649309 100650342 100651761
BAFF : 126923951 126924012 126924928
BPYO : 122570335 122575365 122575766
BPAS : 132911599 132911682 132913931
FVI : 122528408 122532762 122536336
CCAL : 108626630 108628261 108630835
OBB : 114874433 114876424 114883107
OLG : 117603982 117604167 117605030
MGEN : 117222094 117223028 117225172
NMEA : 116429251 116429544 116431352
CGIG : 122396188 122401744 122405321
MPHA : 105833729 105837793
ACEP : 105622013 105626161
PBAR : 105429073 105430103
PCF : 106784078 106784802 106790186
PFUC : 122513965 122521467 122523545
VPS : 122627349 122629531 122633897
VCRB : 124423844 124424596 124429252
VVE : 124946418 124949768 124953299
CSOL : 105365278 105367405
TPRE : 106651781 106657105
MDL : 103571724 103580624 103581013
CGLO : 123262848 123264729 123271459
FAS : 105267024 105267045 105273108
DAM : 107035459 107038309 107040618
AGIF : 122850084 122854975 122858939
CINS : 118065975 118067286 118072453
VCAN : 122405799 122409035 122419042
CCIN : 107263166 107264542 107268185
NPT : 124214662 124215857 124216333
NFB : 124177744 124179718 124179772
NLO : 107225363 107225787 107228052
NVG : 124301176 124301738 124302293
AROA : 105683634 105688474 105692011
DPA : 109536145 109543348 109546236
SOY : 115874612 115874613 115882775 115884798 115887382 115887387
AGRG : 126733859 126738665 126747994
CSET : 123308802 123315573
LDC : 111505843 111507221 111507902
APLN : 108734318 108734964
PPYR : 116164872 116167113 116167115
OTU : 111413356 111420464 111424671
BMOR : 101745975 101747087 110385458
BMAN : 114239703 114242067 114245089
MSEX : 115447604 115448198 115452805
DPL : KGM_204534 KGM_208907 KGM_208923
BANY : 112043461 112053037 112054680
MJU : 123865156 123867426 123867893
VCD : 124532237 124532620 124540248
MCIX : 123655116 123655262
PMAC : 106720588 106720604
PPOT : 106103498 106111711
PRAP : 110995185 110995601 111002035
PNAP : 125063227 125063752
ZCE : 119837157 119840388 119840581
CCRC : 123692979 123693453
LSIN : 126968374 126968604
AAGE : 121726859 121727171
HAW : 110383922 110383939(kuz)
HZE : 124631700 124632072 124641174
TNL : 113494213 113500625 113500765 113500808
SLIU : 111351070 111355438 111355647
OFU : 114353679 114361841 114366719
PXY : 105382897 105393130 105396406
PGW : 126369364 126369451 126376521 126381587
CFEL : 113372655 113373467 113373521
CCRN : 123292762 123301277 123305777
ACOO : 126833894 126847541
BTAB : 109032598 109034688
CLEC : 106663669 106669688
HHAL : 106683289 106686740
PHU : Phum_PHUM259590 Phum_PHUM259860
TPAL : 117649610 117649987
CSEC : 111862333 111867292
SGRE : 126293282 126293640
BROR : 134528432 134535070
DPX : DAPPUDRAFT_310789 DAPPUDRAFT_99915
PCHN : 125033622 125040023
PMOO : 119577766 119597465
HAME : 121853479 121863996 121879430
PCLA : 123766772 123773138
PTRU : 123502954 123510302
HAZT : 108671972 108679974
EAF : 111698034 111704670 111709038 111712714 111713433
LSM : 121113583 121122187 121131774 121131882
PPOI : 119089849 119111239 119111240 119111242 119111857
ISC : 8024889 8027278 8042795
DSV : 119432845 119448863 119455611 119455860 119456432 119456691 119456715 119456719 119456995 119457614 119462221 119462270 119462273
RSAN : 119375037 119381865 119393090 119393092 119393264 119394647 119394802 119394815 119394848 119394854 119394903 119394905 119394920 119397371
RMP : 119168276 119169701 119171595 119171598 119171781 119172289 119172596 119172734 119172754 119172892 119173739 119184081 119184932 119185859 119187018
VDE : 111245256 111245594 111253857
DPTE : 113798778 113799663
CSCU : 111613172 111613173 111613407 111614136 111614137 111614139 111614240 111615624 111615759 111615991 111616905 111618210 111620746 111623196 111623747 111624325 111624877 111625632 111626438 111626652 111627032 111627083 111627483 111627824 111628010 111629830 111629832 111630954 111631584 111633071 111633611 111633801 111634224 111635885 111636742 111636753 111636760 111636761 111638165 111638761 111638786 111639124 111640125 111640608 111641017 111641263 111641264 111641416
PTEP : 107437723 107445643 107448159 107455245
ABRU : 129958943 129972715 129975525 129976095 129981456
UDV : 129219954 129227340 129231158
SDM : 118185997 118186283 118186863 118188832 118200803 118203260
LPOL : 106457004 106457284 106466516 106472701 106477018
CBR : CBG_12369(Cbr-sup-17)
BMY : BM_BM3076(Bma-sup-17)
HRO : HELRODRAFT_113770 HELRODRAFT_191436
LGI : LOTGIDRAFT_138941 LOTGIDRAFT_235956 LOTGIDRAFT_54048
PVUL : 126815205 126815554 126821586
PCAN : 112555188 112566009 112577167
BGT : 106051225 106055443 106059943
GAE : 121369787 121370310 121370363 121372011 121372012 121373320 121373354
HRJ : 124253926 124268832 124269537
CRG : 105317458 105323098 105346452 105347325 109620949 117687376 117687384
CVN : 111112332 111117423 111117731 111117732 111117733
CANU : 128171357 128171999 128172249 128178972
OED : 125651171 125660929 125660930 125662187
MYI : 110450489 110457318 110465949 110466983
PMAX : 117314957 117315663 117322949 117339763
MMER : 123542283 123542541 123544997 123559793
RPHI : 132713553 132714667 132716161 132731502 132731503 132732396 132732397 132735627 132744168
DPOL : 127849932 127850896 127868181 127869545 127871710
LAK : 106151004 106168401 106177601 106177612 106180087
SHX : MS3_00010597(ADAM10_1)
NVE : 5501630 5513665 5517822
EPA : 110237622 110248525 110254921
ATEN : 116290581 116291980 116308772
AMIL : 114949978 114958833 114961861
PDAM : 113670791 113672703 113683701
SPIS : 111334955 111336097 111340547
DGT : 114519082 114522772 114530322 114530383 114536582
XEN : 124439126 124439129 124439431 124447186 124451092 124452214
TAD : TRIADDRAFT_19172 TRIADDRAFT_19354 TRIADDRAFT_51548 TRIADDRAFT_51549 TRIADDRAFT_52298 TRIADDRAFT_56535 TRIADDRAFT_60597 TRIADDRAFT_62134 TRIADDRAFT_62135
AQU : 100632085 105314001 109584186
MBR : MONBRDRAFT_29860 MONBRDRAFT_31368
SRE : PTSG_01510 PTSG_07825 PTSG_10317
» show all
Taxonomy
Reference
Authors
Gutwein P, Mechtersheimer S, Riedle S, Stoeck A, Gast D, Joumaa S, Zentgraf H, Fogel M, Altevogt DP.
Title
ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 3.4.24.81