| Entry |
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| Name |
ADAMTS13 endopeptidase;
ADAMTS VWF cleaving metalloprotease;
ADAMTS-13;
ADAMTS13;
vWF-cleaving protease;
VWF-CP;
vWF-degrading protease;
Upshaw factor;
von Willebrand factor cleaving protease;
ADAMTS13 peptidase
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
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| Reaction(IUBMB) |
The enzyme cleaves the von Willebrand factor at bond Tyr842!Met843 within the A2 domain
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| Comment |
In peptidase family M12.
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| History |
EC 3.4.24.87 created 2009
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| Orthology |
| K08627 | a disintegrin and metalloproteinase with thrombospondin motifs 13 |
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| Genes |
| CSAB: | 103239684(ADAMTS13) |
| CATY: | 105580513(ADAMTS13) |
| PANU: | 101018650(ADAMTS13) |
| MLEU: | 105528703(ADAMTS13) |
| PTEH: | 111523982(ADAMTS13) |
| CANG: | 105503983(ADAMTS13) |
| CIMI: | 108292312(ADAMTS13) |
| CSYR: | 103273391(ADAMTS13) |
| MMUR: | 105880760(ADAMTS13) |
| LCAT: | 123646680(ADAMTS13) |
| PCOQ: | 105826699(ADAMTS13) |
| MCAL: | 110312498(Adamts13) |
| MPAH: | 110317485(Adamts13) |
| MCOC: | 116091905(Adamts13) |
| ANU: | 117701923 117703988(Adamts13) |
| MAUA: | 101827371(Adamts13) |
| PROB: | 127222654(Adamts13) |
| PLEU: | 114684226(Adamts13) |
| MORG: | 121462687(Adamts13) |
| AAMP: | 119818562(Adamts13) |
| CPOC: | 100727045(Adamts13) |
| CCAN: | 109696127(Adamts13) |
| DORD: | 105995613(Adamts13) |
| PLOP: | 125353276(Adamts13) |
| MMMA: | 107159168(Adamts13) |
| CLUD: | 112677392(ADAMTS13) |
| MPUF: | 101694125(ADAMTS13) |
| PCOO: | 112860307(ADAMTS13) |
| PVIV: | 125150198(ADAMTS13) |
| PPAD: | 109258253(ADAMTS13) |
| BBUB: | 102412616(ADAMTS13) |
| BBIS: | 104987950(ADAMTS13) |
| BTAX: | 128056485(ADAMTS13) |
| CCAD: | 122442334(ADAMTS13) |
| MBEZ: | 129539798(ADAMTS13) |
| CBAI: | 105068608(ADAMTS13) |
| BACU: | 102999611(ADAMTS13) |
| BMUS: | 118897540(ADAMTS13) |
| PCAD: | 102996576(ADAMTS13) |
| PSIU: | 116755106(ADAMTS13) |
| NASI: | 112411327(ADAMTS13) |
| MMYO: | 118666904(ADAMTS13) |
| EFUS: | 103296148(ADAMTS13) |
| SHON: | 118980285(ADAMTS13) |
| PDIC: | 114511173(ADAMTS13) |
| PHAS: | 123823380(ADAMTS13) |
| PPAM: | 129079464(ADAMTS13) |
| PALE: | 102885523(ADAMTS13) |
| PGIG: | 120599714(ADAMTS13) |
| SARA: | 101548412(ADAMTS13) |
| SETR: | 126009354(ADAMTS13) |
| PCOC: | 116234434(ADAMTS13) |
| TPAI: | 128073573(ADAMTS13) |
| LMUT: | 125702505(ADAMTS13) |
| NMEL: | 110406845(ADAMTS13) |
| APLA: | 101800615(ADAMTS13) |
| ACYG: | 106044108(ADAMTS13) |
| CATA: | 118252273(ADAMTS13) |
| AFUL: | 116496934(ADAMTS13) |
| SCAN: | 103819131(ADAMTS13) |
| PMOA: | 120512419(ADAMTS13) |
| PRUF: | 121362425(ADAMTS13) |
| PMAJ: | 107212053(ADAMTS13) |
| CCAE: | 111937039(ADAMTS13) |
| CBRC: | 103623248(ADAMTS13) |
| ACHL: | 103809287(ADAMTS13) |
| MMEA: | 130576694(ADAMTS13) |
| PCRI: | 104028886(ADAMTS13) |
| PLET: | 104624643(ADAMTS13) |
| PCAO: | 104047343(ADAMTS13) |
| ACUN: | 113486351(ADAMTS13) |
| TALA: | 104363650(ADAMTS13) |
| PADL: | 103915348(ADAMTS13) |
| AFOR: | 103905329(ADAMTS13) |
| ACHC: | 115335017(ADAMTS13) |
| HALD: | 104323021(ADAMTS13) |
| CCRI: | 104163978(ADAMTS13) |
| CSTI: | 104561782(ADAMTS13) |
| CMAC: | 104483793(ADAMTS13) |
| BREG: | 104632222(ADAMTS13) |
| GSTE: | 104261947(ADAMTS13) |
| SHAB: | 115617127(ADAMTS13) |
| DPUB: | 104296479(ADAMTS13) |
| PGUU: | 104469452(ADAMTS13) |
| ACAR: | 104527328(ADAMTS13) |
| CPEA: | 104389819(ADAMTS13) |
| AVIT: | 104278033(ADAMTS13) |
| CUCA: | 104066938(ADAMTS13) |
| BRHI: | 104489548(ADAMTS13) |
| AROW: | 112964357(ADAMTS13) |
| SCAM: | 104138242(ADAMTS13) |
| CPOO: | 109313985(ADAMTS13) |
| CCAY: | 125623621(ADAMTS13) |
| CABI: | 116817469(ADAMTS13) |
| PMUR: | 107300476 107302802(ADAMTS13) |
| CTIG: | 120298847(ADAMTS13) |
| APRI: | 131186207(ADAMTS13) |
| PTEX: | 113443776(ADAMTS13) |
| PMUA: | 114589118(ADAMTS13) |
| PRAF: | 128406410(ADAMTS13) |
| RTEM: | 120913870(ADAMTS13) |
| BBUF: | 120977996(ADAMTS13) |
| BGAR: | 122946443(ADAMTS13) |
| SRX: | 107725310 107740991(adamts13) |
| SANH: | 107691575(adamts13) 107702807 |
| SGH: | 107548275 107565123(adamts13) |
| CAUA: | 113070702(adamts13) |
| PTET: | 122350338(adamts13) |
| LROH: | 127169433(adamts13) |
| PPRM: | 120473833(adamts13) |
| MAMB: | 125279476(adamts13) |
| TROS: | 130568092(adamts13) |
| MANU: | 129415088(adamts13) |
| PHYP: | 113533593(adamts13) |
| SMEO: | 124399846(adamts13) |
| AMEX: | 103029987(adamts13) |
| CMAO: | 118813326(adamts13) |
| CHAR: | 105894886(adamts13) |
| TBEN: | 117472614(adamts13) |
| CGOB: | 115013592(adamts13) |
| PGEO: | 117452414(adamts13) |
| GACU: | 117543933(adamts13) |
| EMAC: | 134873591(adamts13) |
| PLEP: | 121944087(adamts13) |
| SLUC: | 116050540(adamts13) |
| ECRA: | 117944827(adamts13) |
| PFLV: | 114555418(adamts13) |
| PPUG: | 119225063(adamts13) |
| CLUM: | 117735888(adamts13) |
| PSWI: | 130196825(adamts13) |
| MSAM: | 119891655(adamts13) |
| SCHU: | 122876145(adamts13) |
| ALAT: | 119019795(adamts13) |
| CSAI: | 133451247(adamts13) |
| PRET: | 103470625(adamts13) |
| PFOR: | 103147041(adamts13) |
| PLAI: | 106939142(adamts13) |
| PMEI: | 106917656(adamts13) |
| PPRL: | 129372958(adamts13) |
| CTUL: | 119785140(adamts13) |
| ALIM: | 106516687(adamts13) |
| AOCE: | 111586394(adamts13) |
| MCEP: | 125012297(adamts13) |
| SSEN: | 122769584(adamts13) |
| HHIP: | 117767414(adamts13) |
| SMAU: | 118313805(adamts13) |
| SLAL: | 111644942(adamts13) |
| SBIA: | 133499364(adamts13) |
| PTAO: | 133475627(adamts13) |
| BPEC: | 110169902(adamts13) |
| MALB: | 109954821(adamts13) |
| BSPL: | 114861250(adamts13) |
| SASA: | 106579902(adamts13) |
| STRU: | 115200048(adamts13) |
| SALP: | 111957513(adamts13) |
| CCLU: | 121551928(adamts13) |
| AANG: | 118206510(adamts13) |
| PSPA: | 121309677(adamts13) |
| ARUT: | 117396819 117422042 |
| PSEX: | 120536068(adamts13) |
| CPLA: | 122564630(adamts13) |
| LERI: | 129712093(adamts13) |
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| Reference |
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| Authors |
Fujikawa K, Suzuki H, McMullen B, Chung D |
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| Title |
Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Dong JF, Moake JL, Nolasco L, Bernardo A, Arceneaux W, Shrimpton CN, Schade AJ, McIntire LV, Fujikawa K, Lopez JA |
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| Title |
ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 3.4.24.87 |
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