KEGG ENZYME: 3.5.1.109

ENZYME: 3.5.1.109

Entry

EC 3.5.1.109                Enzyme

Name

sphingomyelin deacylase;
SM deacylase;
GcSM deacylase;
glucosylceramide sphingomyelin deacylase;
sphingomyelin glucosylceramide deacylase;
SM glucosylceramide GCer deacylase;
SM-GCer deacylase;
SMGCer deacylase

Class

Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides

Sysname

N-acyl-sphingosylphosphorylcholine amidohydrolase

Reaction(IUBMB)

(1) an N-acyl-sphingosylphosphorylcholine + H2O = a fatty acid + sphingosylphosphorylcholine;
(2) a D-glucosyl-N-acylsphingosine + H2O = a fatty acid + D-glucosyl-sphingosine

Substrate

N-acyl-sphingosylphosphorylcholine;
H2O [CPD:C00001];
D-glucosyl-N-acylsphingosine [CPD:C01190]

Product

fatty acid [CPD:C00162];
sphingosylphosphorylcholine;
D-glucosyl-sphingosine

Comment

The enzyme is involved in the sphingolipid metabolism in the epidermis.

History

EC 3.5.1.109 created 2011

Reference

1 [PMID:10951276]

Authors

Hara J, Higuchi K, Okamoto R, Kawashima M, Imokawa G

Title

High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis.

Journal

J Invest Dermatol 115:406-13 (2000)
DOI:10.1046/j.1523-1747.2000.00072.x

Reference

2 [PMID:10970788]

Authors

Higuchi K, Hara J, Okamoto R, Kawashima M, Imokawa G

Title

The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide.

Journal

Biochem J 350 Pt 3:747-56 (2000)

Reference

3 [PMID:12649340]

Authors

Ishibashi M, Arikawa J, Okamoto R, Kawashima M, Takagi Y, Ohguchi K, Imokawa G

Title

Abnormal expression of the novel epidermal enzyme, glucosylceramide deacylase, and the accumulation of its enzymatic reaction product, glucosylsphingosine, in the skin of patients with atopic dermatitis.

Journal

Lab Invest 83:397-408 (2003)
DOI:10.1097/01.lab.0000059931.66821.92

Other DBs

ExplorEnz - The Enzyme Database:

3.5.1.109

IUBMB Enzyme Nomenclature:

3.5.1.109

ExPASy - ENZYME nomenclature database:

3.5.1.109

BRENDA, the Enzyme Database:

3.5.1.109

All links

No link information was found.

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