KEGG   ENZYME: 3.5.1.113
Entry
EC 3.5.1.113                Enzyme                                 
Name
2'''-acetyl-6'''-hydroxyneomycin C deacetylase;
neoL (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
Sysname
2'''-acetyl-6'''-hydroxyneomycin C hydrolase (acetate-forming)
Reaction(IUBMB)
2'''-acetyl-6'''-deamino-6'''-hydroxyneomycin C + H2O = 6'''-deamino-6'''-hydroxyneomycin C + acetate [RN:R08901]
Reaction(KEGG)
R08901
Substrate
2'''-acetyl-6'''-deamino-6'''-hydroxyneomycin C;
H2O [CPD:C00001]
Product
6'''-deamino-6'''-hydroxyneomycin C [CPD:C17588];
acetate [CPD:C00033]
Comment
Involved in the biosynthetic pathway of aminoglycoside antibiotics of the neomycin family. The enzyme from the bacterium Streptomyces fradiae also catalyses EC 3.5.1.112, 2'-N-acetylparomamine deacetylase.
History
EC 3.5.1.113 created 2012
Pathway
ec00524  Neomycin, kanamycin and gentamicin biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K17078  2'-N-acetylparomamine deacetylase / 2'''-acetyl-6'''-hydroxyneomycin deacetylase
Genes
PMUY: KSS95_17150
SRN: A4G23_05119(neoL)
SNF: JYK04_00663(neoL)
SFB: CP974_27320
STRY: EQG64_18475
SDD: D9753_07125 D9753_17065
SARG: HKX69_16470
SPIQ: OHA34_16955
DVC: Dvina_05430
Reference
1  [PMID:18311744]
  Authors
Yokoyama K, Yamamoto Y, Kudo F, Eguchi T
  Title
Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis.
  Journal
Chembiochem 9:865-9 (2008)
DOI:10.1002/cbic.200700717
  Sequence
[ag:BAD95829]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.113
IUBMB Enzyme Nomenclature: 3.5.1.113
ExPASy - ENZYME nomenclature database: 3.5.1.113
BRENDA, the Enzyme Database: 3.5.1.113

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (12)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (2)   
   InterPro (2)   
All databases (28)   

Download RDF
DBGET integrated database retrieval system