KEGG   ENZYME: 3.5.1.121
Entry
EC 3.5.1.121                Enzyme                                 
Name
protein N-terminal asparagine amidohydrolase;
NTAN1 (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
Sysname
protein N-terminal asparagine amidohydrolase
Reaction(IUBMB)
N-terminal L-asparaginyl-[protein] + H2O = N-terminal L-aspartyl-[protein] + NH3 [RN:R11559]
Reaction(KEGG)
R11559
Substrate
N-terminal L-asparaginyl-[protein] [CPD:C21465];
H2O [CPD:C00001]
Product
N-terminal L-aspartyl-[protein] [CPD:C21458];
NH3 [CPD:C00014]
Comment
This enzyme participates in the eukaryotic ubiquitin-dependent Arg/N-end rule pathway of protein degradation, promoting the turnover of intracellular proteins that initiate with Met-Asn. Following the acetylation and removal of the initiator methionine, the exposed N-terminal asparagine is deaminated, resulting in its conversion to L-aspartate. The latter serves as a substrate for EC 2.3.2.8, arginyltransferase, making the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule.
History
EC 3.5.1.121 created 2016
Orthology
K14662  protein N-terminal asparagine amidohydrolase
Genes
HSA123803(NTAN1)
PTR107968797(NTAN1)
PPS100988607(NTAN1)
GGO101154065(NTAN1)
PON100449883 103892635(NTAN1)
NLE100581837(NTAN1)
HMH116462456(NTAN1)
MCC100427569(NTAN1)
MCF102126239(NTAN1)
MTHB126944532
MNI105467727(NTAN1)
CSAB103228771(NTAN1)
CATY105572207(NTAN1)
PANU101024918(NTAN1)
TGE112614843(NTAN1)
RRO104678414(NTAN1)
RBB108524244(NTAN1)
TFN117097624(NTAN1)
PTEH111524534(NTAN1)
CANG105502332(NTAN1)
CJC100393568(NTAN1)
SBQ101036086(NTAN1)
CIMI108307861(NTAN1)
CSYR103267251(NTAN1)
MMUR105885328(NTAN1)
LCAT123632408(NTAN1)
PCOQ105813112(NTAN1)
OGA100960371
MMU18203(Ntan1)
MCAL110311860(Ntan1)
MPAH110330086(Ntan1)
RNO360462(Ntan1)
MCOC116085599(Ntan1)
ANU117710015(Ntan1)
MUN110556846(Ntan1)
CGE100772842(Ntan1)
MAUA101841102(Ntan1)
PROB127231531 127238222(Ntan1)
PLEU114683989(Ntan1)
MORG121464052(Ntan1)
MFOT126490702
AAMP119813350(Ntan1)
NGI103731551(Ntan1)
HGL101726114(Ntan1)
CPOC100716021(Ntan1)
CCAN109694568(Ntan1)
DORD105981855(Ntan1)
DSP122123742(Ntan1)
PLOP125341202(Ntan1)
NCAR124970753
MMMA107146819(Ntan1)
OCU100356960
OPI101517159(NTAN1)
TUP102469256(NTAN1)
GVR103607168(NTAN1)
CFA609485(NTAN1)
CLUD112640342(NTAN1)
VVP112923230(NTAN1)
VLG121487850(NTAN1)
NPO129519201(NTAN1)
AML100471097(NTAN1)
UMR103668621(NTAN1)
UAH113270768(NTAN1)
UAR123778621(NTAN1)
ELK111156175
LLV125090884
MPUF101680450(NTAN1)
MNP132006832 132026883(NTAN1)
MLK131820090(NTAN1) 131821209
NVS122895864(NTAN1) 122906798
ORO101372020(NTAN1)
EJU114219847(NTAN1)
ZCA113932050(NTAN1) 113935629
MLX118012382 118022002(NTAN1)
NSU110587833(NTAN1) 110591800
LWW102732497 102748810(NTAN1)
FCA101080602(NTAN1)
PYU121019482(NTAN1)
PCOO112853141(NTAN1)
PBG122471637(NTAN1)
LRUF124517719
PTG102965982(NTAN1)
PPAD109278366(NTAN1)
PUC125927912
AJU106970473
HHV120232743(NTAN1)
BTA505869(NTAN1)
BOM102286611(NTAN1)
BIU109578413(NTAN1)
BBUB102415521(NTAN1)
BBIS104988530(NTAN1)
CHX102176660(NTAN1)
OAS101113380(NTAN1)
BTAX128070849(NTAN1)
ODA120875080(NTAN1)
CCAD122432863(NTAN1)
MBEZ129545397(NTAN1)
SSC397107(NTAN1)
CFR102506624(NTAN1)
CBAI105073744(NTAN1)
CDK105091380(NTAN1)
VPC102527681(NTAN1)
BACU103013489(NTAN1)
LVE103073824(NTAN1) 103082409
OOR101283828(NTAN1)
DLE111163560(NTAN1)
PCAD102976879(NTAN1)
PSIU116739600(NTAN1)
NASI112399196(NTAN1)
ECB100053937(NTAN1)
EPZ103551161(NTAN1)
EAI106847174(NTAN1)
MYB102264249(NTAN1)
MYD102756106(NTAN1)
MMYO118656045(NTAN1)
MLF102423742(NTAN1)
MNA107524353(NTAN1)
PKL118703750(NTAN1)
EFUS103286095(NTAN1)
HAI109395248(NTAN1)
DRO112315035(NTAN1)
SHON119002077(NTAN1)
AJM119046273(NTAN1)
PDIC114507783(NTAN1)
PHAS123806524(NTAN1)
MMF118641892(NTAN1)
RFQ117019431(NTAN1) 117032797
PPAM129083703(NTAN1)
PALE102892177(NTAN1)
PGIG120620424(NTAN1)
PVP105290944(NTAN1)
RAY107518205(NTAN1)
MJV108398600(NTAN1)
TOD119241900(NTAN1) 119246661
SARA101539572(NTAN1)
LAV100665272(NTAN1)
TMU101360654
ETF101654100(NTAN1)
DNM101443024(NTAN1)
MDO100016963(NTAN1)
GAS123233051(NTAN1)
SHR100933204(NTAN1)
AFZ127538934
PCW110218801(NTAN1)
OAA100087098(NTAN1)
GGA768445(NTAN1)
PCOC116237516(NTAN1)
MGP100540862(NTAN1)
CJO107320510(NTAN1)
TPAI128078881(NTAN1)
LMUT125700512(NTAN1)
NMEL110406002(NTAN1)
APLA101801451(NTAN1)
ACYG106033441(NTAN1)
CATA118249037(NTAN1)
AFUL116495515(NTAN1)
TGU100232216(NTAN1)
LSR110475483(NTAN1)
SCAN103817709(NTAN1)
PMOA120513254(NTAN1)
OTC121334623(NTAN1)
PRUF121350909(NTAN1)
GFR102039699(NTAN1)
FAB101813056(NTAN1)
OMA130259057(NTAN1)
PHI102102370(NTAN1)
PMAJ107211212(NTAN1)
CCAE111935972(NTAN1)
CCW104684901(NTAN1)
CBRC103615478(NTAN1)
ETL114058244(NTAN1)
ZAB102073535(NTAN1)
ACHL103801224(NTAN1)
SVG106865220(NTAN1)
MMEA130574231(NTAN1)
HRT120759461(NTAN1)
FPG101915235(NTAN1)
FCH102050117(NTAN1)
CLV102088442(NTAN1)
EGZ104126974(NTAN1)
NNI104015022(NTAN1)
PCRI104024572(NTAN1)
PLET104622245(NTAN1)
EHS104511243(NTAN1)
PCAO104051458(NTAN1)
ACUN113485524(NTAN1)
TALA104355861(NTAN1)
PADL103917582(NTAN1)
AFOR103900861(NTAN1)
ACHC115335768(NTAN1)
HALD104318251(NTAN1)
HLE104838636(NTAN1)
AGEN126053319
GCL127022280
CCRI104164892(NTAN1)
CSTI104549493(NTAN1)
CMAC104482613(NTAN1)
MUI104534133(NTAN1)
BREG104632834(NTAN1)
FGA104070003(NTAN1)
GSTE104258797(NTAN1)
LDI104348786(NTAN1)
MNB103775784(NTAN1)
OHA104331008(NTAN1)
NNT104400087(NTAN1)
SHAB115607241(NTAN1)
DPUB104298853(NTAN1)
PGUU104469107(NTAN1)
ACAR104525310(NTAN1)
CPEA104393701(NTAN1)
AVIT104268315(NTAN1)
CVF104287843(NTAN1)
RTD128913292(NTAN1)
CUCA104058757(NTAN1)
TEO104378799(NTAN1)
BRHI104498617(NTAN1)
AAM106482588(NTAN1)
AROW112971338(NTAN1)
NPD112959952(NTAN1)
TGT104570629(NTAN1)
DNE112981021(NTAN1)
SCAM104149763(NTAN1)
ASN102377030(NTAN1)
AMJ102575745(NTAN1)
CPOO109313531(NTAN1)
GGN109290703(NTAN1)
PSS102453559(NTAN1)
CMY102940436(NTAN1)
CCAY125644388(NTAN1)
DCC119862748(NTAN1)
CPIC101951460(NTAN1)
TST117883948(NTAN1)
CABI116832598(NTAN1)
MRV120373088(NTAN1)
ACS100565856(ntan1)
ASAO132776509 132781841(NTAN1)
PVT110087210(NTAN1)
SUND121914748(NTAN1)
PBI103054148(NTAN1)
PMUR107297517(NTAN1)
CTIG120315860(NTAN1)
PGUT117673080(NTAN1)
APRI131185115(NTAN1)
PTEX113438729(NTAN1)
NSS113427906(NTAN1)
VKO123024929(NTAN1)
PMUA114584630(NTAN1)
PRAF128401244(NTAN1)
ZVI118092601(NTAN1)
HCG128336528(NTAN1)
GJA107107580
STOW125430725(NTAN1)
EMC129338176(NTAN1) 129344141
XLA779182(ntan1.L)
XTR100145352(ntan1)
NPR108801042(NTAN1)
RTEM120944406(NTAN1)
BBUF121008900(NTAN1)
BGAR122945012(NTAN1)
MUO115475403(NTAN1)
GSH117345532(NTAN1)
DRE393824(ntan1)
SRX107705820(ntan1)
SANH107666719
SGH107582303(ntan1)
CCAR109046802(ntan1)
CAUA113089442(ntan1)
CGIB127959015
PTET122333284(ntan1)
LROH127167417(ntan1)
OMC131542977(ntan1)
PPRM120467905(ntan1)
RKG130076483(ntan1)
MAMB125274065(ntan1)
CIDE127514604
MASI127445913 127448686
TROS130556920(ntan1)
TDW130424488(ntan1)
MANU129450266(ntan1)
IPU100528093(ntan1)
IFU128615323(ntan1)
PHYP113538187(ntan1)
SMEO124393192(ntan1)
TFD113634538(ntan1)
TVC132844866(ntan1)
AMEX103029101(ntan1)
CMAO118807922(ntan1)
EEE113584081(ntan1)
CHAR105913224(ntan1)
TRU101079012(ntan1)
TFS130527054(ntan1)
TNGGSTEN00011848G001
LCO109139545(ntan1)
NCC104941195(ntan1)
TBEN117480858(ntan1)
CGOB115023872(ntan1)
PGEO117453864(ntan1)
GACU117537239(ntan1)
ELY117254813(ntan1)
EFO125886253(ntan1)
PLEP121942101(ntan1)
SLUC116057209(ntan1)
ECRA117956944(ntan1)
ESP116705194(ntan1)
PFLV114570711(ntan1)
GAT120824815(ntan1)
PPUG119217591 119217744
AFB129096025(ntan1)
CLUM117737824(ntan1)
MSAM119884084(ntan1)
SCHU122873887(ntan1)
CUD121507880(ntan1)
ALAT119019655(ntan1)
MZE101484909(ntan1)
ONL100700038(ntan1)
OAU116331362(ntan1)
OLA101166197(ntan1)
OML112137554(ntan1)
XMA102234761(ntan1)
XCO114144532(ntan1)
XHE116719559(ntan1)
PRET103464690(ntan1)
PFOR103131844(ntan1)
PLAI106943173(ntan1)
PMEI106930859(ntan1)
GAF122829243(ntan1)
PPRL129366789(ntan1)
CVG107096612(ntan1)
CTUL119798010(ntan1)
GMU124868403(ntan1)
NFU107392933(ntan1)
KMR108236320(ntan1)
ALIM106524640(ntan1)
NWH119422871(ntan1)
AOCE111581304(ntan1)
MCEP125004347(ntan1)
CSEM103384052(ntan1)
POV109627250(ntan1)
SSEN122771161(ntan1)
HHIP117768390(ntan1)
HSP118121554(ntan1)
LCF108875736
SDU111229239(ntan1)
SLAL111666702(ntan1)
XGL120799715(ntan1)
HCQ109527302(ntan1)
SSCV125968393
SBIA133505860(ntan1)
PEE133404640(ntan1)
PTAO133476392(ntan1)
BPEC110175752(ntan1)
MALB109957879(ntan1)
BSPL114855354(ntan1)
SJO128371495(ntan1)
SASA100195037(ntan1) 106564562(NTAN1)
STRU115147326 115178438
OTW112230209 112263432(ntan1)
OMY100305342(ntan1) 110485694
OGO124003799 124016135
ONE115103659 115119263
OKI109865934 109882883
OKE118373599 118376601
SALP112075974(ntan1)
SNH120032537(ntan1)
CCLU121557651(ntan1)
ELS105012175(ntan1)
SFM108927396(ntan1)
PKI111848643(ntan1)
AANG118220055(ntan1)
LOC102684418(ntan1) 107075902
PSPA121331050
ARUT117418060(ntan1) 117432821
PSEX120541991(ntan1)
LCM102361811(NTAN1)
CMK103178783(ntan1)
RTP109936994(ntan1)
CPLA122560897(ntan1)
HOC132825319(ntan1)
LERI129707078(ntan1)
PMRN116955113(NTAN1)
LRJ133358724(NTAN1)
BFO118429752
BBEL109485250
CIN100184734
SCLV120342306
SPU115918669 576087
LPIC129269338
APLC110985459
AJC117108630
SKO100376842
DMEDmel_CG5473(Ntan1)
DER6547216
DSE6609831
DSIDsimw501_GD25375(Dsim_GD25375)
DYADyak_GE13898
DAN6495646
DSR110178471
DPO4803758
DPE6591132
DMN108158486 117185725
DWI6640943
DGR6560376
DMODmoj_GI20358
DAZ108617230
DNV108653564
DHE111604133
DVI6625385
CCAT101454954
BOD106627830
BDR105229971
RZE108366670
AOQ129243825
TDA119664874 119679927 119680451 119682568 119687204
MDE101887337 131800396
SCAC106093671
LCQ111688145
GFS119641594 119643561
ECOE129952196
CLON129614624
HIS119660021
AGA1270999
ACOZ120957209
AARA120902135
AMER121599521
ASTE118504896
AFUN125770608
AMOU128310574
AALI118467428
AAG5565729
AALB109408720
CQUCpipJ_CPIJ016351
CPII120415444 120427099
CNS116352350
BCOO119081799
AME412885
ACER108000581
ALAB122713344
ADR102676081
AFLR100870894
BIM100743196
BBIF117212875
BVK117237028
BTER100650604
BAFF126920074
BPYO122570934
BPAS132905875
FVI122533976
CCAL108623454
OBB114878379
OLG117606257
MGEN117220182
NMEA116428089
CGIG122396937
SOC105196325
MPHA105836310
AEC105145108
ACEP105623986
PBAR105429026
VEM105569990
HST105181906
DQU106748268
CFO105248633
FEX115234622
LHU105674442
PGC109856943
OBO105286714
PCF106792260
PFUC122513905
VPS122633705
VCRB124429210
VVE124953475
NVI100115435
CSOL105366538
TPRE106658205
LHT122500693
LBD127286305
MDL103577429
CGLO123264392
FAS105264203
DAM107042226
AGIF122854636
CINS118068445
VCAN122416015
CCIN107264137
DSM124414597
NPT124223291
NFB124186189
NLO107218359
NVG124308742
AROA105693796
TCA655408
DPA109537845 109540227
SOY115885082 115888366
AGRG126741113 126747019
ATD109596607
CSET123314515
AGB108905210 108916340
LDC111503135 111503436 111505009
NVL108566820
APLN108734447
PPYR116173588
OTU111413790
BMOR101740662
BMAN114241315
MSEX115449030 119188494
DPLKGM_206168
BANY112051559
MJU123868094
NIQ126774417
VCD124536178
MCIX123659714
PMAC106713840
PPOT106104644
PXU106121355
PRAP111003040
PBX123709574
PNAP125048613
ZCE119840793
CCRC123694172
LSIN126970325
HAW110371976
HZE124634892
TNL113497368
SLIU111359153
OFU114355222
PXY105380889
PGW126372772
CFEL113387632
CCRN123298005
API100160095 100167144
DNX107163256
AGS114120587
RMD113560480
ACOO126833445
DVT126907106
BTAB109039103
DCI103511843
CLEC106671143
HHAL106678435
NLU111049425
HVI124354192
MQU129003979 129004276
PHUPhum_PHUM188470
FOC113207211
TPAL117651286
ZNE110834044
CSEC111865139
SGRE126334572 126354746
IEL124165061
FCD110848081
DPXDAPPUDRAFT_197112 DAPPUDRAFT_305857
DMK116930216 116935916
DPZ124326023 124350952
PVM113808980 113812857
PJA122254359 122257453
PCHN125039954
PMOO119583686 119597714
HAME121858144 121861052
PCLA123771875 123774050
CQD128684225 128696635
PTRU123512186 123512845
ESN126985583 127008610
HAZT108674506 108677225
EAF111696928 111699733 111713146 111713151
LSM121113994 121116639 121126173 121130179
TCF131876960 131887769
PPOI119103390 119103963
DSV119453172
RSAN119399979
RMP119180352
VDE111248493
VJA111273574
TUT107359486
DPTE113799393
DFR124496160
CSCU111630859
PTEP107457160
UDV129234444
SDM118191992
LPOL106465375 106471058
HROHELRODRAFT_99061
LGILOTGIDRAFT_186232
PVUL126812139
PCAN112575188
BGT106057608
GAE121379410
HRJ124282570
CRG105335781
CVN111118541
CANU128165778
OED125668481
MYI110463922
PMAX117337413
MCAF127709856
MMER123563994
RPHI132743715
DPOL127866540
OBI106879332
OSN115211960
LAK106161871 106161893
SMMSmp_066830
EPA110240041
ATEN116303244
ADF107341481
AMIL114959453
PDAM113677050
SPIS111320038
DGT114519229 114541793
XEN124447824 124447828 124448447
HMG105850568
HSY130656874
TADTRIADDRAFT_52945
ATHAT2G44420
ALY9316178
CRB17888641
CSAT104782989 104784896 104793386
EUSEUTSA_v10001527mg
BRP103866793
BNA106390764 106396413
BOE106337179 106339587
RSZ108835758
THJ104827577
CPAP110806976
CIT102625830
CICCICLE_v10031978mg
PVY116133204
MINC123214495
TCC18614680
GRA105790273
GHI107918472 107926127
GAB108468816
HSYR120136797
DZI111310421
EGR104454003 108953839
GMX100806375
GSJ114421966
PVUPHAVU_005G039600g
VRA106759882
VAR108334459
VUN114165340
VUM124843405 124843407
CCAJ109805769
APRC113855362
MTR11418572
TPRA123898127
CAM101504861
PSAT127134326
VVO131594937 131599278
LJALj3g3v0917040.2(Lj3g3v0917040.2)
ADU107458782
AIP107613640
AHF112702971 112771962
LANG109347925
PCIN129315143
QSAO6P43_029479
FVE101309081
RCN112172371
PPER18787441
PMUM103330504 103343900
PAVI110752505
PDUL117620199
MDM103407492 103409956
MSYL126598434 126628522
PXB103942378 103945821 103947155
ZJU107410331
MNT21385985
CSAV115724192
CSV101208664
CMO103500294
BHJ120091993
MCHA111020342
CMAX111481410
CMOS111442418
CPEP111791866
RCU8289191
JCU105650338
HBR110669329
MESC110625114
POP7488165
PEU105137815
PALZ118053811
JRE109001501
CILL122292198
CAVE132177842 132179740
QSU111988557
QLO115984146 115987789 115988123
TWL119998473
VVI100245927
VRI117927645 117928745
SLY101251321
SPEN107011465
SOT102599742
SSTN125853298
SDUL129886911
CANN107838813
LBB132644440
NTA107819197 107830782
NSY104235664
NTO104097926
NAU109230960
INI109163873
ITR116028690
SIND105168640
OEU111410440
EGT105969577
SSPL121805213 121809722
APAN127260179
HAN110874793
ECAD122581110
LSV111897344
CCAV112519528
DCR108200438
CSIN114313116
RVL131334259
AEW130795746
BVG104904931
SOE110785492
CQI110699185
ATRI130802972
MOF131151658
NNU104603537
MING122060916
TSS122642013
PSOM113307943 113320250
OSA9266522
DOSAOs06t0618150-00(Os06g0618150)
OBR102721938
OGL127776545
BDI100827044
ATS109731442
TDC119330301 119337508
TAES123148456 123156374 123165387
TUA125528507
LPER127295521 127312957
LRD124681428 124696184 124696747 124703142
SBI8083461
ZMA100192828
SITA101770691
SVS117852143
PVIR120671133 120703937
PHAI112888795
PDA103718424
EGU105039450
MUS103973239
ZOF121980014 122037952
DCT110107138
PEQ110024689
AOF109840972
MSIN131222385
NCOL116262794
ATR18439784
SMOSELMODRAFT_431467
VCNVOLCADRAFT_103207
CVRCHLNCDRAFT_138942
MBRMONBRDRAFT_5128
PTIPHATRDRAFT_44704
TPSTHAPSDRAFT_23827
NGDNGA_2013200
SPARSPRG_20537
GTTGUITHDRAFT_152563
 » show all
Reference
1  [PMID:8089117]
  Authors
Stewart AE, Arfin SM, Bradshaw RA
  Title
Protein NH2-terminal asparagine deamidase. Isolation and characterization of a new enzyme.
  Journal
J Biol Chem 269:23509-17 (1994)
  Sequence
[ssc:397107]
Reference
2  [PMID:8910481]
  Authors
Grigoryev S, Stewart AE, Kwon YT, Arfin SM, Bradshaw RA, Jenkins NA, Copeland NG, Varshavsky A
  Title
A mouse amidase specific for N-terminal asparagine. The gene, the enzyme, and their function in the N-end rule pathway.
  Journal
J Biol Chem 271:28521-32 (1996)
DOI:10.1074/jbc.271.45.28521
  Sequence
[mmu:18203]
Reference
3  [PMID:21375249]
  Authors
Cantor JR, Stone EM, Georgiou G
  Title
Expression and biochemical characterization of the human enzyme N-terminal asparagine amidohydrolase.
  Journal
Biochemistry 50:3025-33 (2011)
DOI:10.1021/bi101832w
  Sequence
[hsa:123803]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.121
IUBMB Enzyme Nomenclature: 3.5.1.121
ExPASy - ENZYME nomenclature database: 3.5.1.121
BRENDA, the Enzyme Database: 3.5.1.121

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