Entry
Name
protein N-terminal glutamine amidohydrolase;
NTAQ1 (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
protein N-terminal glutamine amidohydrolase
Reaction(IUBMB)
N-terminal L-glutaminyl-[protein] + H2O = N-terminal L-glutamyl-[protein] + NH3 [RN:
R11560 ]
Reaction(KEGG)
Substrate
N-terminal L-glutaminyl-[protein] [CPD:
C02986 ];
H2O [CPD:
C00001 ]
Product
N-terminal L-glutamyl-[protein] [CPD:
C21456 ];
NH3 [CPD:
C00014 ]
Comment
This enzyme participates in the eukaryotic ubiquitin-dependent Arg/N-end rule pathway of protein degradation, promoting the turnover of intracellular proteins that initiate with Met-Gln. Following the acetylation and removal of the initiator methionine, the exposed N-terminal glutamine is deaminated, resulting in its conversion to L-glutamate. The latter serves as a substrate for EC
2.3.2.8 , arginyltransferase, making the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule.
History
EC 3.5.1.122 created 2016
Orthology
K21286 protein N-terminal glutamine amidohydrolase
Genes
MUN : 110552391 110553350(Ntaq1)
DSP : 122102485(Ntaq1) 122113903
OCU : 100351002 100351397(NTAQ1)
PSIU : 116742169(WDYHV1) 116751462
RAY : 107503227 107521598(WDYHV1)
CJO : 107306780 107310545(WDYHV1)
APLA : 113840568 113841596 113841736 113841786
PMUR : 107295158(WDYHV1) 107301275
ZVI : 118077737 118090232(NTAQ1)
CCAR : 109111633 109112233
MASI : 127421031 127425378
TNG : GSTEN00001049G001 GSTEN00033685G001
ARUT : 117435290 117962324
PSEX : 120515536 120521941
DSI : Dsimw501_GD11140(Dsim_GD11140)
AALB : 109403811 109406324 115263302
DPA : 109540649 125504089 125504090 125504686
CFEL : 113374784 113382237
PPOI : 119089674 119089757 119090708
LPOL : 106458005 106459929
CEL : CELE_R06C7.6(R06C7.6)
CANU : 128174508 128190229
RPHI : 132719408 132750212
SHX : MS3_00002221(WDYHV1_1)
CSAT : 104782676 104785194 104785195 104793100 109132805
LJA : Lj0g3v0276439.1(Lj0g3v0276439.1)
CSAV : 115708881 115709894
CANN : 107870075 124885472
SSPL : 121795142 121799564
DOSA : Os05t0387900-01(Os05g0387900)
TAES : 123130951 123143490 123181860
PVIR : 120665642 120698852
SMO : SELMODRAFT_48349 SELMODRAFT_68426
TVS : TRAVEDRAFT_22741 TRAVEDRAFT_71054
ABP : AGABI1DRAFT34630(AGABI1DRAFT_34630)
ABV : AGABI2DRAFT64499(AGABI2DRAFT_64499)
» show all
Taxonomy
Reference
Authors
Wang H, Piatkov KI, Brower CS, Varshavsky A
Title
Glutamine-specific N-terminal amidase, a component of the N-end rule pathway.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 3.5.1.122