KEGG ENZYME: 3.5.1.129

ENZYME: 3.5.1.129

Entry

EC 3.5.1.129                Enzyme

Name

N5-(cytidine 5'-diphosphoramidyl)-L-glutamine hydrolase;
N5-(cytidine 5'-diphosphoramidyl)-L-glutamine deacylase

Class

Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides

Sysname

N5-(cytidine 5'-diphosphoramidyl)-L-glutamine amidohydrolase

Reaction(IUBMB)

N5-(cytidine 5'-diphosphoramidyl)-L-glutamine + H2O = cytidine 5'-diphosphoramidate + L-glutamate [RN:R12251]

Reaction(KEGG)

R12251

Substrate

N5-(cytidine 5'-diphosphoramidyl)-L-glutamine [CPD:C22033];
H2O [CPD:C00001]

Product

cytidine 5'-diphosphoramidate [CPD:C22031];
L-glutamate [CPD:C00025]

Comment

The enzyme, characterized from the bacterium Campylobacter jejuni, is involved in formation of a unique O-methyl phosphoramidate modification on specific sugar residues within the bacterium's capsular polysaccharides.

History

EC 3.5.1.129 created 2018

Orthology

K23150

N5-(cytidine 5'-diphosphoramidyl)-L-glutamine hydrolase

Genes

PROD:

PCO85_05455

DDC:	Dd586_1832

VAF:	D1115_22865

PMK:

MDS_1829

PPU:

PP_0727

PPUT:

L483_03690

PMON:

X969_02145

PMOT:

X970_02125

PALD:

LU682_003955

PFO:	Pfl01_5513

PRX:	HRH33_09095

PCH:	EY04_30525

PCZ:	PCL1606_01890

PCP:	JM49_01205

PCHP:

C4K32_6098

PSEM:

TO66_30420

PSET:

THL1_4060

PTK:	EXN22_13985

PPEG:

KUA23_08575

PFIT:

KJY40_29495

PASI:

LG197_09070

PKK:	QQ992_04065

PHOM:

KJF94_05600

PCHE:

QYM18_22765

MHC:

MARHY0658

SPL:

Spea_1405

AGZ:	M0C34_07885

MMT:	Metme_1181

TZO:	THMIRHAT_08550

HHA:

Hhal_0772

HHK:	HH1059_03440 HH1059_03560 HH1059_03650 HH1059_03870

OME:	OLMES_3126

AHA:

AHA_4153

AEO:	O23A_p3862

ADH:	CK627_03020

THO:	SP60_02250

CHIC:

N8I74_10220

BBRO:

BAU06_24695

ACHR:

C2U31_03840

ACHB:

DVB37_27200

CDN:	BN940_10776

OTR:	OTERR_09330

REN:	EF513_06955

AVV:	RvVAT039_pl03330

AVI:

Avi_7109

RPEL:

N7U68_00610

MALU:

KU6B_11440

PAED:

G5B38_20025

ALI:	AZOLI_p60025

ATI:	AL072_31795

AZM:	DM194_26720

MGY:	MGMSRv2__3428

MAGX:

XM1_2454

THAR:

T8K17_08585

PEL:	SAR11G3_00126

HHE:

HH_1437

HCP:

HCN_1066

HCB:	HCBAA847_0909

HBL:	XJ32_09980

HAD:	CDV25_08805

HCL:	NCTC13205_00568

HPUL:

NCTC13154_00543

WSU:

WS2179

CJE:

Cj1417c

CJB:	BN148_1417c

CJJ:	CJJ81176_1416

CJU:

C8J_0638

CJI:

CJSA_1348

CJM:

CJM1_0656

CJP:	A911_06895

CJEJ:

N564_01414

CJEU:

N565_01454

CJEN:

N755_01451

CJEI:

N135_01506

CJER:

H730_08040

CJV:	MTVDSCj20_0695

CJY:	QZ67_01552(carA_1)

CJQ:

UC78_1359

CJW:	PJ18_07240

CJD:	JJD26997_1750

CJZ:	M635_02760

CJX:	BN867_06850

CFF:	CFF8240_1631

CFT:	CFF04554_1633

CFV:	CFVI03293_1655

CFX:	CFV97608_1758

CFZ:

CSG_17650

CAMP:

CFT03427_1583

CFP:	CR44_08045

CLA:

CLA_0315

CLN:	UPTC3659_1408

CLL:	CONCH_1263

CCOL:

BN865_14290

CCF:

YSQ_05945

CCY:

YSS_03095

CCOI:

YSU_05595

CIS:

CINS_0305

CSM:	CSUB8521_0347

CSF:	CSUB8523_0329

CHV:	CHELV3228_1342

CCUN:

CCUN_1304

CUX:	CUP3940_0678

CINF:

CINF_1340

CNV:	CNZW441b_1098

CVU:	CVULP_0993

GLO:

Glov_3393

DSD:	GD606_13315

DVM:

DvMF_0015

CLIH:

KPS_000026

DOA:	AXF15_00625

CCX:	COCOR_06830(pabA)

MAI:

MICA_1013

PIH:	UB51_00300

CEV:	LK421_10975

SHI:	Shel_12660

SGZ:	C0216_11015

AACD:

LWP59_19210

LED:	BBK82_30190

PMAD:

BAY61_25140

PMF:	P9303_29431

FPOL:

ERS445057_00336

NVA:	G3M78_01020

SAIM:

K0C01_02800

NPH:

NP_1950A

HALY:

HYG82_02845

NAJ:	B1756_14545

NMR:

Nmar_0661

NIW:	Nisw_04295

NUE:	C5F50_00560

» show all

Reference

1 [PMID:29023101]

Authors

Taylor ZW, Brown HA, Holden HM, Raushel FM

Title

Biosynthesis of Nucleoside Diphosphoramidates in Campylobacter jejuni.

Journal

Biochemistry 56:6079-6082 (2017)
DOI:10.1021/acs.biochem.7b00905

Sequence

[cje:Cj1417c]

Other DBs

ExplorEnz - The Enzyme Database:

3.5.1.129

IUBMB Enzyme Nomenclature:

3.5.1.129

ExPASy - ENZYME nomenclature database:

3.5.1.129

BRENDA, the Enzyme Database:

3.5.1.129

DBGET integrated database retrieval system