Entry
Name
peptidyl-glutaminase;
peptidoglutaminase I;
peptideglutaminase;
peptidoglutaminase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
peptidyl-L-glutamine amidohydrolase
Reaction(IUBMB)
alpha-N-peptidyl-L-glutamine + H2O = alpha-N-peptidyl-L-glutamate + NH3 [RN:
R04341 ]
Reaction(KEGG)
Substrate
Product
Comment
Specific for the hydrolysis of the gamma-amide of glutamine substituted at the alpha-amino group, e.g., glycyl-L-glutamine, N-acetyl-L-glutamine and L-leucylglycyl-L-glutamine.
History
EC 3.5.1.43 created 1976
Reference
Authors
Kikuchi M, Hayashida H, Nakano E, Sakaguchi K.
Title
Peptidoglutaminase. Enzymes for selective deamidation of gamma-amide of peptide-bound glutamine.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.43
ExPASy - ENZYME nomenclature database: 3.5.1.43