KEGG   ENZYME: 3.5.1.92
Entry
EC 3.5.1.92                 Enzyme                                 
Name
pantetheine hydrolase;
pantetheinase;
vanin;
vanin-1
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
Sysname
(R)-pantetheine amidohydrolase
Reaction(IUBMB)
(R)-pantetheine + H2O = (R)-pantothenate + 2-aminoethanethiol [RN:R02973]
Reaction(KEGG)
R02973
Substrate
(R)-pantetheine [CPD:C00831];
H2O [CPD:C00001]
Product
(R)-pantothenate [CPD:C00864];
2-aminoethanethiol [CPD:C01678]
Comment
The enzyme hydrolyses only one of the amide bonds of pantetheine. The substrate analogues phosphopantetheine and CoA are not substrates. The enzyme recycles pantothenate (vitamin B5) and produces 2-aminoethanethiol (cysteamine), a potent anti-oxidant [5].
History
EC 3.5.1.92 created 2006
Pathway
ec00770  Pantothenate and CoA biosynthesis
ec01100  Metabolic pathways
Orthology
K08069  pantetheine hydrolase
Genes
HSA8875(VNN2) 8876(VNN1)
PTR463006(VNN3) 463007(VNN2) 746544(VNN1)
PPS100978332 100978987(VNN3) 100979321(VNN2)
GGO101125335 101126064(VNN3) 101126426(VNN2)
PON100436777 100441056(VNN1) 100441798(VNN3)
NLE100579766(VNN1) 100580443(VNN3) 115830450
HMH116472399 116472421(VNN3) 116472484
MCC708637 708748 708830
MCF101865481(VNN2) 102139623 102139985
MTHB126952876 126952877 126952878
MNI105465628 105465629 105465630(VNN2)
CSAB103240351(VNN2) 103240352 103240354
CATY105600441(VNN2) 105600443 105600573
PANU101022791(VNN2) 101023852 101024198(VNN1)
TGE112622739(VNN2) 112622834 112622835
MLEU105531096(VNN2) 105531097 105535035(VNN1) 105535149
RRO104657993(VNN2) 104657995 104657997
RBB108534302(VNN1) 108534304 108534340
TFN117097514(VNN2) 117097515 117097516(VNN1)
PTEH111554892(VNN1) 111554930(VNN2) 111554957(VNN3)
CANG105526209(VNN2) 105526211(VNN3) 105526250
CJC100399050(VNN1) 100399411(VNN3P) 100895783
SBQ101042912 101043241(VNN1)
CIMI108283984(VNN1) 108283985(VNN3)
CSYR103260966(VNN1) 103260967(VNN3) 103260969
MMUR105855558 105855559(VNN1) 105855561
LCAT123633282(VNN1) 123633283 123633284
PCOQ105827199(VNN1) 105827200 105827203
OGA100951307 100959690 100959693 100960002
MMU22361(Vnn1) 26464(Vnn3)
MCAL110303054(Vnn1) 110303935
MPAH110338225(Vnn1) 110338323
RNO29142(Vnn1) 498992(Vnn3)
MCOC116097698 116097699
ANU117701008(Vnn1) 117701029
MUN110565409 110565420
CGE100750608(Vnn1) 100754161
MAUA101825185 110339751(Vnn1)
PROB127215070(Vnn1)
MORG121449567(Vnn1)
MFOT126511923
AAMP119820817 119821684
NGI103724951(Vnn2) 103724954(Vnn1)
HGL101710059(Vnn1) 101724572(Vnn3)
CPOC100728678(Vnn1) 100728953(Vnn3)
CCAN109687502(Vnn1) 109687517(Vnn2)
DORD105993512(Vnn1) 105993513
DSP122116881 122117054
PLOP125357296(Vnn1) 125357732
NCAR124988630 124989575 124989745
MMMA107155491(Vnn1) 107155505(Vnn2)
OCU100344919 100345689 100356303
OPI101524958 101527393
TUP102490124(VNN1) 102490829(VNN3) 102491237(VNN2)
GVR103602493(VNN1) 103602503 103602521
CFA442973(VNN1)
CLUD112644136
VVP112919447(VNN1)
VLG121484510(VNN1)
NPO129509251(VNN1)
AML100465598(VNN1)
UMR103663395(VNN1)
UAH113259459(VNN1) 113259677(VNN3)
UAR123797578(VNN1)
ELK111147800
LLV125102712
MPUF101672747(VNN1)
MNP132018172
MLK131833787
NVS122906562(VNN1)
ORO101376044(VNN1) 101385601(VNN3)
EJU114225647(VNN3) 114225655
ZCA113927558 113927853
MLX118000789 118001370
NSU110583229(VNN1) 110583238
LWW102742992(VNN1)
FCA101096984 101097240
PYU121013451(VNN1) 121013452
PCOO112862121 112862287
PBG122489999 122490000
LRUF124528590 124529365
PTG102970509(VNN3) 102971182(VNN1)
PPAD109249916(VNN1) 109249917
PUC125937987 125937988
AJU106976871 106976873
HHV120238345(VNN1)
BTA526704(VNN1) 534929(VNN2)
BOM102269407(VNN1) 102269960(VNN2)
BIU109563954(VNN1) 109563957
BBUB102410831(VNN2) 102411389(VNN1)
BBIS104991694(VNN2) 104991697(VNN1)
CHX102172899(VNN1) 102173569
OAS101105005(VNN1) 101105417(VNN2)
BTAX128053288 128053334(VNN2)
ODA120863042(VNN1) 120863045(VNN2)
CCAD122434053 122434054(VNN1)
MBEZ129560941 129561107
SSC100152784(VNN3) 100153984(VNN2) 397246(VNN1)
CFR102514326 102514743(VNN3) 102515010(VNN2)
CBAI105077234(VNN1) 105077235 105077236(VNN2)
CDK105096352(VNN1) 105096353(VNN3) 105096354(VNN2)
VPC102539632 102540045(VNN3) 102540292(VNN2)
BACU103010543(VNN1) 103011016 103011299(VNN2)
LVE103079030(VNN2) 103079497(VNN1) 103084601
OOR101284042(VNN2) 101284462(VNN1)
DLE111165830(VNN2) 111165838(VNN1)
PCAD102989061 102995508(VNN2)
PSIU116763260(VNN2) 116763733(VNN1)
NASI112409092 112409114(VNN1) 112409135(VNN2)
ECB100067649 100067672(VNN2) 100146975
EPZ103557081(VNN2) 103557083 103557085(VNN1)
EAI106840575 106840577 106840579
MYB102246494(VNN1) 102247599 102247887(VNN2)
MYD102761007(VNN1) 102761476(VNN2) 102772945
MMYO118659851 118660324 118660430
MLF102424773 102425091 102440862(VNN2)
MNA107530954 107530955 107530957(VNN1)
PKL118706142(VNN1) 118706143 118706144
EFUS103285078 103305552(VNN2) 103305561
HAI109372141(VNN1) 109372142 109372153 109395289
DRO112297069 112297375
SHON118986690(VNN2) 118986693 118986770
AJM119039937(VNN2)
PDIC114494440(VNN2) 114494515
PHAS123821368(VNN2) 123821617
MMF118621074(VNN2) 118621116 118621118
RFQ117019053 117020605 117020619
PPAM129066927 129066928 129067782
PALE102881910 102882154 102894153(VNN2)
PGIG120615808(VNN2) 120615809 120615810(VNN1)
PVP105289491(VNN2) 105289492 105289493
RAY107499937(VNN3) 107499949(VNN1) 107499950(VNN2)
MJV108397063(VNN2) 108398567 108398575
TOD119253454 119253455
SARA101550949(VNN2) 101551220 101553342
LAV100670289 100671136(VNN1)
TMU101350854 101351285 101351544 101352933
ETF101650218(VNN2) 101650530(VNN1) 101657922
DNM101431017(VNN2) 101432321 101433074(VNN1)
MDO100031271(VNN1) 100031277(VNN3)
GAS123245590 123245591
SHR100933586 100934104
AFZ127559591 127562223
PCW110208893 110208894
OAA100074927(VNN1) 100085853
GGA421702(VNN1)
PCOC116240276 116240286
MGP100541961 100542733
CJO107311722(VNN1) 107311723
TPAI128089126 128089135
LMUT125688958
NMEL110396026
APLA101798228 101798418 101798651
ACYG106032501 106032502 106032503(VNN1)
CATA118243867 118244010 118244011
AFUL116487964 116488055
TGU100217969 100220807
LSR110476003 110476058
SCAN103820544 103820609
PMOA120501231 120501233
OTC121346174
PRUF121354853
GFR102038583(VNN1) 102041126(VNN2)
FAB101807492(VNN1) 101808136
OMA130251849 130251850
PHI102100467 102102180
PMAJ107201269 107202003
CCAE111927686 111927687
CCW104690571 104690581 120411723
CBRC103619321 103619323 103619430
ETL114064430
ZAB102065972 102066154
ACHL103805516
SVG106851869 106851918
MMEA130572596 130572598 130572599
HRT120749836 120749837
FPG101924145(VNN3) 101924317
FCH102058065(VNN1)
CLV102083923 102093091
EGZ104131148 104131149 104131209
NNI104008832 104008833 104008895
PCRI104036061 104036070
PLET104617008 104618055 104618474
EHS104503488 104505046 104510687
PCAO104040252 104041959
ACUN113478767 113478768
TALA104357197 104357198 104357199
PADL103912691 103912692 103912737
AFOR103900749 103900751 103900811
ACHC115344455(VNN1)
HALD104311949 104322071 104322212
HLE104836426 104836427 104841707
AGEN126038976 126038986
GCL127014646 127014647
CCRI104164598 104164599 104164600
CSTI104550535 104551148 104551731
CMAC104479085 104484334 104484335
MUI104534652 104548055
BREG104640481 104640482 104641728
FGA104076973 104076976
GSTE104263031 104263032 104263034
LDI104343154 104344396 104344399
MNB103770208 103778662
OHA104327060 104327062 104327100
NNT104407474 104407475 104407476
SHAB115609597 115609598 115609599
DPUB104308652 104308653
PGUU104466262(VNN1) 104466265 104466266
ACAR104519000 104521607
CPEA104390128(VNN1)
AVIT104272794 104272795
CVF104282097 104282098 104282124
RTD128907274 128907275 128907512
CUCA104058236 104058237
TEO104382842 104383006 104383016
BRHI104490011 104498401
AAM106497918 106497928
AROW112969461 112969462 112969471
NPD112954906 112954924 112954925
TGT104564311 104574506
DNE112995728 112995765
SCAM104153126 104153127 104153166
ASN102384310 102384548 102386374
AMJ102558568 102560408 102560855(VNN2)
CPOO109312025 109312026 109312027
GGN109299757 109299761 109299762
PSS102445936(VNN1) 102446172
CMY102942174
CCAY125634160(VNN1)
DCC119852690 119853874
CPIC101933999 122172113
TST117874922 117874923
CABI116824890 116824891(VNN1)
MRV120400847 120401411
ACS100553191 100566816
ASAO132760978(VNN1) 132760979
PVT110071965 110071970(VNN1)
SUND121928449 121928453
PBI103059808 103060046
PMUR107297840 107297842 107297843 107299200
CTIG120299250 120299293
TSR106541945 106543075 106551933(VNN3)
PGUT117666274 117666276
APRI131192449 131192455
PTEX113439597(VNN1) 113439601
NSS113411183(VNN1)
VKO123020545 123032829
PMUA114594152 114594153
PRAF128410546 128410547
ZVI118082089 118082092
HCG128341301 128341319
GJA107110525(VNN1) 107110527
STOW125429402(VNN1) 125438954
EMC129341115 129341395
XLA108705431 108705439
XTR496642(vnn1) 496713(vnn2)
NPR108799348
RTEM120937325 120937326
BBUF120998503(VNN1) 120998504
BGAR122934963 122936134
MUO115465813 115466895(VNN1)
GSH117357482 117357548
PSPA121316927
ARUT117410868
PMRN116953019
LRJ133347589
BFO118406135
BBEL109461734 109480583 109486691
SKO100371918
DMK116926132
PJA122260577 122261978
PCHN125024539 125048283
PCLA123761105
CQD128702985
PTRU123504183
ESN127006955
HAZT108667421
PPOI119097192 119097862 119114813
TUT107372229
DPTE113791482 113793022 113793031
DFR124495498 124495976 124499332
CSCU111631959 111631967 111632207
PTEP107443103 107445458 107445778
UDV129217225 129223377 129224593 129224916 129231644
SDM118180521 118200208
LPOL106462040
PMEO129581086
LGILOTGIDRAFT_128172 LOTGIDRAFT_204287 LOTGIDRAFT_218395
PVUL126824406 126828239 126828240
PCAN112557879 112570933
BGT106058822
GAE121383811 121390084 121390479
HRF124116384 124116395 124116396 124117751 124152859
HRJ124257501 124262810 124279646
CRG105345878
CVN111133168 111135357
CANU128187257
OED125678926
MYI110445423 110452379 110463544
PMAX117317063 117320438 117333384 117333873 117344473
MCAF127712520 127712521 127720838 127729463
MMER123552251
RPHI132730077 132730087 132732357 132753748 132757146 132757147 132757152 132758016 132758020 132758021
DPOL127833490 127860185 127860381 127869323 127876282
OBI106868079 106868152 106874210
OSN115209793 115213146 115226225
LAK106153227 106179638 106179639
NVE5506952 5509997
EPA110253943
ATEN116300340 116300841
ADF107357429
AMIL114976578
PDAM113665188
SPIS111337869
DGT114524553 114524573 114527090
XEN124434554
TADTRIADDRAFT_21249
 » show all
Reference
1  [PMID:440106]
  Authors
Dupre S, Cavallini D.
  Title
Purification and properties of pantetheinase from horse kidney.
  Journal
Methods Enzymol 62:262-7 (1979)
DOI:10.1016/0076-6879(79)62227-9
Reference
2  [PMID:6549111]
  Authors
Dupre S, Chiaraluce R, Nardini M, Cannella C, Ricci G, Cavallini D.
  Title
Continuous spectrophotometric assay of pantetheinase activity.
  Journal
Anal Biochem 142:175-81 (1984)
DOI:10.1016/0003-2697(84)90534-7
Reference
3  [PMID:10567687]
  Authors
Maras B, Barra D, Dupre S, Pitari G.
  Title
Is pantetheinase the actual identity of mouse and human vanin-1 proteins?
  Journal
FEBS Lett 461:149-52 (1999)
DOI:10.1016/S0014-5793(99)01439-8
  Sequence
[hsa:8876] [mmu:22361]
Reference
4  [PMID:8934567]
  Authors
Aurrand-Lions M, Galland F, Bazin H, Zakharyev VM, Imhof BA, Naquet P.
  Title
Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing.
  Journal
Immunity 5:391-405 (1996)
DOI:10.1016/S1074-7613(00)80496-3
  Sequence
[mmu:22361]
Reference
5  [PMID:11042271]
  Authors
Pitari G, Malergue F, Martin F, Philippe JM, Massucci MT, Chabret C, Maras B, Dupre S, Naquet P, Galland F.
  Title
Pantetheinase activity of membrane-bound Vanin-1: lack of free cysteamine in tissues of Vanin-1 deficient mice.
  Journal
FEBS Lett 483:149-54 (2000)
DOI:10.1016/S0014-5793(00)02110-4
  Sequence
[mmu:22361]
Reference
6  [PMID:11491533]
  Authors
Martin F, Malergue F, Pitari G, Philippe JM, Philips S, Chabret C, Granjeaud S, Mattei MG, Mungall AJ, Naquet P, Galland F.
  Title
Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes.
  Journal
Immunogenetics 53:296-306 (2001)
DOI:10.1007/s002510100327
  Sequence
[hsa:8876 8875] [mmu:26464]
Reference
7  [PMID:11380987]
  Authors
Pace HC, Brenner C.
  Title
The nitrilase superfamily: classification, structure and function.
  Journal
Genome Biol 2:REVIEWS0001 (2001)
DOI:10.1186/gb-2001-2-1-reviews0001
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.92
IUBMB Enzyme Nomenclature: 3.5.1.92
ExPASy - ENZYME nomenclature database: 3.5.1.92
BRENDA, the Enzyme Database: 3.5.1.92
CAS: 56093-18-6

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