KEGG ENZYME: 3.5.3.25

ENZYME: 3.5.3.25

Entry

EC 3.5.3.25                 Enzyme

Name

Nomega-hydroxy-L-arginine amidinohydrolase;
dcsB (gene name)

Class

Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amidines

Sysname

Nomega-hydroxy-L-arginine amidinohydrolase

Reaction(IUBMB)

Nomega-hydroxy-L-arginine + H2O = L-ornithine + hydroxyurea [RN:R10466]

Reaction(KEGG)

R10466

Substrate

Nomega-hydroxy-L-arginine;
H2O [CPD:C00001]

Product

L-ornithine [CPD:C00077];
hydroxyurea [CPD:C07044]

Comment

The enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species.

History

EC 3.5.3.25 created 2013

Pathway

ec00998

Biosynthesis of various antibiotics

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K19723

Nomega-hydroxy-L-arginine amidinohydrolase

Reference

1 [PMID:20086163]

Authors

Kumagai T, Koyama Y, Oda K, Noda M, Matoba Y, Sugiyama M

Title

Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae.

Journal

Antimicrob Agents Chemother 54:1132-9 (2010)
DOI:10.1128/AAC.01226-09

Sequence

[ag:BAI70376]

Reference

2 [PMID:22547619]

Authors

Kumagai T, Takagi K, Koyama Y, Matoba Y, Oda K, Noda M, Sugiyama M

Title

Heme protein and hydroxyarginase necessary for biosynthesis of D-cycloserine.

Journal

Antimicrob Agents Chemother 56:3682-9 (2012)
DOI:10.1128/AAC.00614-12

Sequence

[ag:BAI70376]

Other DBs

ExplorEnz - The Enzyme Database:

3.5.3.25

IUBMB Enzyme Nomenclature:

3.5.3.25

ExPASy - ENZYME nomenclature database:

3.5.3.25

BRENDA, the Enzyme Database:

3.5.3.25

DBGET integrated database retrieval system