Entry Name arginine dihydrolase;
Class Hydrolases;BRITE hierarchy
Sysname L-arginine aminodihydrolase (L-ornithine-forming)
Reaction(IUBMB) L-arginine + 2 H2O = L-ornithine + CO2 + 2 ammonia [RN:
R13308 ]
Reaction(KEGG) Substrate Product Comment The enzyme, characterized from different cyanobacterial species, is highly specific to arginine and does not require a metal cofactor. The enzyme from Nostoc is bifunctional, and also catalyses the activity of EC
4.3.1.12 , ornithine cyclodeaminase.
History EC 3.5.3.27 created 2024
Reference Authors Zhang H, Liu Y, Nie X, Liu L, Hua Q, Zhao GP, Yang C.
Title The cyanobacterial ornithine-ammonia cycle involves an arginine dihydrolase.
Journal Sequence Reference Authors Burnat M, Picossi S, Valladares A, Herrero A, Flores E.
Title Catabolic pathway of arginine in Anabaena involves a novel bifunctional enzyme that produces proline from arginine.
Journal Sequence Reference Authors Zhuang N, Zhang H, Li L, Wu X, Yang C, Zhang Y.
Title Crystal structures and biochemical analyses of the bacterial arginine dihydrolase ArgZ suggests a "bond rotation" catalytic mechanism.
Journal Sequence Other DBs ExplorEnz - The Enzyme Database: 3.5.3.27
ExPASy - ENZYME nomenclature database: 3.5.3.27
