KEGG   ENZYME: 3.5.4.11
Entry
EC 3.5.4.11                 Enzyme                                 
Name
pterin deaminase;
acrasinase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
Sysname
2-amino-4-hydroxypteridine aminohydrolase
Reaction(IUBMB)
a 2-amino-4-hydroxypteridine + H2O = a 2,4-dihydroxypteridine + NH3
Reaction(KEGG)
(other) R02815
Substrate
2-amino-4-hydroxypteridine [CPD:C00715];
H2O [CPD:C00001]
Product
2,4-dihydroxypteridine [CPD:C03212];
NH3 [CPD:C00014]
Comment
The animal enzyme is specific for pterin, isoxanthopterin and tetrahydropterin.
History
EC 3.5.4.11 created 1965
Reference
1  [PMID:13654299]
  Authors
LEVENBERG B, HAYAISHI O.
  Title
A bacterial pterin deaminase.
  Journal
J Biol Chem 234:955-61 (1959)
Reference
2  [PMID:5821022]
  Authors
Rembold H, Simmersbach F.
  Title
Catabolism of pteridine cofactors. II. A specific pterin deaminase in rat liver.
  Journal
Biochim Biophys Acta 184:589-96 (1969)
DOI:10.1016/0304-4165(69)90273-6
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.11
IUBMB Enzyme Nomenclature: 3.5.4.11
ExPASy - ENZYME nomenclature database: 3.5.4.11
BRENDA, the Enzyme Database: 3.5.4.11
CAS: 9025-04-1

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