Entry
Name
8-oxoguanine deaminase;
8-OGD
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
8-oxoguanine aminohydrolase
Reaction(IUBMB)
8-oxoguanine + H2O = urate + NH3 [RN:
R09876 ]
Reaction(KEGG)
Substrate
Product
Comment
Zn2+ is bound in the active site. 8-Oxoguanine is formed via the oxidation of guanine within DNA by reactive oxygen species. If uncorrected, this modification leads to the incorporation of 8-oxoG:A mismatches and eventually to G:C to T:A transversions.
History
EC 3.5.4.32 created 2012
Orthology
Genes
METU : GNH96_06120 GNH96_06195 GNH96_13005
REH : H16_A1363(h16_A1363)
BPM : BURPS1710b_2526(atzB)
MDI : METDI2371(atzB) METDI3796
MCH : Mchl_2016 Mchl_2080 Mchl_3248
MZA : B2G69_16155 B2G69_22675
MRD : Mrad2831_4071 Mrad2831_6206
META : Y590_08145 Y590_14675
MAQU : Maq22A_1p37370(ssnA)
PLEO : OHA_1_01093 OHA_1_02816
CON : TQ29_04730 TQ29_11690
PAMN : JCM7685_1472 pAMV3p0275
KNA : B0W47_00945 B0W47_11405
KEU : S101446_00583 S101446_02612(mtaD)
KSC : CD178_00783 CD178_02099
KRE : GWK63_01555 GWK63_07290
KOI : LV478_07090 LV478_13240
NBR : O3I_016195 O3I_039230
NOZ : DMB37_18050 DMB37_37655
NAH : F5544_19150 F5544_41705
NIE : KV110_18190 KV110_38430
NHU : H0264_08000 H0264_26795
NYA : LTV02_07875 LTV02_25015
RGO : KYT97_07990 KYT97_30730
STRE : GZL_01234 GZL_02612
SLE : sle_14660(sle_14660)
SLS : SLINC_0789 SLINC_6746
SNR : SNOUR_05210 SNOUR_11150
SALU : DC74_6402 DC74_7413
SALL : SAZ_32160 SAZ_38270
SGV : B1H19_31955 B1H19_32515
SCYA : EJ357_37540 EJ357_43190
SAQU : EJC51_06605 EJC51_37375
SCHA : CP983_08875 CP983_40205
SLF : JEQ17_11080 JEQ17_43485
STUB : MMF93_26680 MMF93_29630
SXT : KPP03845_101331(atzA) KPP03845_105895
SYUN : MOV08_05000 MOV08_10950
SCOA : QU709_07650 QU709_41795
STTN : BSL84_01450 BSL84_27040
ARX : ARZXY2_329 ARZXY2_4073
AGEG : MUG94_11735 MUG94_16300
AAU : AAur_3399 AAur_pTC10087(trzN)
PSEI : GCE65_04320 GCE65_05000
KBU : Q4V64_41800 Q4V64_50285
DHI : LH044_19310 LH044_19355 LH044_19395
MICA : P0L94_10150 P0L94_14770
» show all
Taxonomy
Reference
Authors
Hall RS, Fedorov AA, Marti-Arbona R, Fedorov EV, Kolb P, Sauder JM, Burley SK, Shoichet BK, Almo SC, Raushel FM
Title
The hunt for 8-oxoguanine deaminase.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.32
ExPASy - ENZYME nomenclature database: 3.5.4.32