KEGG   ENZYME: 3.5.4.35
Entry
EC 3.5.4.35                 Enzyme                                 
Name
tRNA(cytosine8) deaminase;
CDAT8
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
Sysname
tRNA(cytosine8) aminohydrolase
Reaction(IUBMB)
cytosine8 in tRNA + H2O = uracil8 in tRNA + NH3 [RN:R10232]
Reaction(KEGG)
R10232
Substrate
cytosine8 in tRNA;
H2O [CPD:C00001]
Product
uracil8 in tRNA;
NH3 [CPD:C00014]
Comment
The enzyme from Methanopyrus kandleri specifically catalyses the deamination of cytosine at position 8 of tRNA in 30 different tRNAs. This cytosine-to-uracil editing guarantees the proper folding and functionality of the tRNAs.
History
EC 3.5.4.35 created 2013
Orthology
K16930  tRNA(cytosine8) deaminase
Genes
MKA: MK0935
Reference
1  [PMID:19407206]
  Authors
Randau L, Stanley BJ, Kohlway A, Mechta S, Xiong Y, Soll D
  Title
A cytidine deaminase edits C to U in transfer RNAs in Archaea.
  Journal
Science 324:657-9 (2009)
DOI:10.1126/science.1170123
  Sequence
[mka:MK0935]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.35
IUBMB Enzyme Nomenclature: 3.5.4.35
ExPASy - ENZYME nomenclature database: 3.5.4.35
BRENDA, the Enzyme Database: 3.5.4.35

  All links  
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (3)   
   InterPro (3)   
All databases (13)   

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