mRNA(cytosine6666) deaminase;
APOBEC-1 (catalytic component of an RNA-editing complex);
APOBEC1 (catalytic subunit);
apolipoprotein B mRNA-editing enzyme 1 (catalytic component of an RNA-editing complex);
apoB mRNA-editing enzyme catalytic polypeptide 1 (catalytic component of an RNA-editing complex);
apoB mRNA editing complex;
apolipoprotein B mRNA editing enzyme;
REPR
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
Sysname
mRNA(cytosine6666) aminohydrolase
Reaction(IUBMB)
cytosine6666 in apolipoprotein B mRNA + H2O = uracil6666 in apolipoprotein B mRNA + NH3
Substrate
cytosine6666 in apolipoprotein B mRNA;
H2O [CPD:C00001]
Product
uracil6666 in apolipoprotein B mRNA;
NH3 [CPD:C00014]
Comment
The apolipoprotein B mRNA editing enzyme complex catalyses the editing of apolipoprotein B mRNA at cytidine6666 to uridine, thereby transforming the codon for glutamine-2153 to a termination codon. Editing results in translation of a truncated apolipoprotein B isoform (apoB-48) with distinct functions in lipid transport. The catalytic component (APOBEC-1) contains zinc at the active site [3].