KEGG   ENZYME: 3.5.4.36
Entry
EC 3.5.4.36                 Enzyme                                 
Name
mRNA(cytosine6666) deaminase;
APOBEC-1 (catalytic component of an RNA-editing complex);
APOBEC1 (catalytic subunit);
apolipoprotein B mRNA-editing enzyme 1 (catalytic component of an RNA-editing complex);
apoB mRNA-editing enzyme catalytic polypeptide 1 (catalytic component of an RNA-editing complex);
apoB mRNA editing complex;
apolipoprotein B mRNA editing enzyme;
REPR
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
Sysname
mRNA(cytosine6666) aminohydrolase
Reaction(IUBMB)
cytosine6666 in apolipoprotein B mRNA + H2O = uracil6666 in apolipoprotein B mRNA + NH3
Substrate
cytosine6666 in apolipoprotein B mRNA;
H2O [CPD:C00001]
Product
uracil6666 in apolipoprotein B mRNA;
NH3 [CPD:C00014]
Comment
The apolipoprotein B mRNA editing enzyme complex catalyses the editing of apolipoprotein B mRNA at cytidine6666 to uridine, thereby transforming the codon for glutamine-2153 to a termination codon. Editing results in translation of a truncated apolipoprotein B isoform (apoB-48) with distinct functions in lipid transport. The catalytic component (APOBEC-1) contains zinc at the active site [3].
History
EC 3.5.4.36 created 2013
Orthology
K16932  C->U-editing enzyme APOBEC1
Genes
HSA339(APOBEC1)
PTR748253(APOBEC1)
PPS100987748(APOBEC1)
GGO115930199(APOBEC1)
PON100461036(APOBEC1)
NLE100605699(APOBEC1)
HMH116472216(APOBEC1)
MCC715554(APOBEC1)
MTHB126931383
MNI105484237(APOBEC1)
CSAB103218863(APOBEC1)
CATY105583071(APOBEC1)
PANU101012048(APOBEC1)
TGE112634768(APOBEC1)
MLEU105541832(APOBEC1)
RRO104681677(APOBEC1)
RBB108542064(APOBEC1)
TFN117090577(APOBEC1)
PTEH111555953(APOBEC1)
CANG105519284(APOBEC1)
CJC100394516(APOBEC1)
SBQ101039475(APOBEC1)
CIMI108291836(APOBEC1)
CSYR103265738(APOBEC1)
MMUR105878291(APOBEC1)
LCAT123640046(APOBEC1)
PCOQ105805011(APOBEC1)
OGA100946425(APOBEC1)
MMU11810(Apobec1)
MCAL110295781(Apobec1)
MPAH110317250(Apobec1)
RNO25383(Apobec1)
MCOC116099542(Apobec1)
ANU117715131(Apobec1)
MUN110556295(Apobec1)
CGE100760326(Apobec1)
MAUA101825976(Apobec1)
PROB127236219(Apobec1)
PLEU114683508(Apobec1)
MORG121440297(Apobec1)
MFOT126514922
AAMP119807822(Apobec1)
NGI103727568(Apobec1)
HGL101708425(Apobec1)
CPOC100715170 100730186 100734070(Apobec1)
CCAN109680707(Apobec1)
DORD105991095(Apobec1)
DSP122127020(Apobec1)
NCAR124983984
MMMA107159907(Apobec1)
OCU100009191(APOBEC1)
OPI101520639 101522989(APOBEC1)
TUP102476841(APOBEC1)
GVR103597924(APOBEC1)
CFA486699(APOBEC1)
CLUD112675397(APOBEC1)
VVP112917582(APOBEC1)
NPO129514402(APOBEC1)
AML100473834(APOBEC1)
UMR103669184(APOBEC1)
UAH113258086(APOBEC1)
UAR123781554(APOBEC1)
ELK111142361
LLV125107994
MPUF101678854(APOBEC1)
MNP132020580(APOBEC1)
MLK131837977(APOBEC1)
NVS122891280(APOBEC1)
ORO101375399(APOBEC1)
EJU114221617(APOBEC1)
ZCA113922730(APOBEC1)
MLX118025489(APOBEC1)
NSU110581029(APOBEC1)
LWW102748071(APOBEC1)
FCA101100896(APOBEC1)
PYU121021928(APOBEC1)
PCOO112867762(APOBEC1)
PBG122473575(APOBEC1)
LRUF124501296
PTG102951006(APOBEC1)
PPAD109276062(APOBEC1)
PUC125919802
AJU106965478
HHV120222696(APOBEC1)
BTA516043(APOBEC1)
BOM102271536(APOBEC1)
BIU109558589(APOBEC1)
BBUB102396632(APOBEC1)
BBIS104995478(APOBEC1)
CHX102181846(APOBEC1)
OAS101105238(APOBEC1)
BTAX128048241(APOBEC1)
ODA120858788(APOBEC1)
CCAD122423664(APOBEC1)
MBEZ129536801(APOBEC1)
SSC100512412(APOBEC1)
CFR102517248(APOBEC1)
CBAI105062174(APOBEC1)
CDK105098173(APOBEC1)
VPC102530346(APOBEC1)
BACU103021051(APOBEC1)
LVE103079923(APOBEC1)
OOR101285026(APOBEC1)
DLE111176731(APOBEC1)
PCAD102982551(APOBEC1)
PSIU116760949(APOBEC1)
NASI112391804(APOBEC1)
ECB100061100(APOBEC1)
EPZ103556649(APOBEC1)
EAI106837455(APOBEC1)
MYB102246260(APOBEC1)
MYD102753131(APOBEC1)
MMYO118651239(APOBEC1)
MLF102440453(APOBEC1)
MNA107543986(APOBEC1)
PKL118729809(APOBEC1)
EFUS103285073(APOBEC1)
HAI109372734(APOBEC1)
DRO112321971(APOBEC1)
SHON119002328(APOBEC1)
AJM119065729(APOBEC1)
PDIC114513897(APOBEC1)
PHAS123819396(APOBEC1)
MMF118624211(APOBEC1)
RFQ117028964(APOBEC1)
PPAM129085033(APOBEC1)
PALE102879919(APOBEC1)
PGIG120611750(APOBEC1)
PVP105295919(APOBEC1)
RAY107501654(APOBEC1)
MJV108409186(APOBEC1)
TOD119247038 119248368(APOBEC1)
SARA105943074(APOBEC1)
LAV100656399(APOBEC1)
TMU101361717
ETF101650731(APOBEC1)
DNM101414784(APOBEC1)
MDO554187(APOBEC1)
GAS123250608(APOBEC1)
SHR100932638(APOBEC1)
AFZ127564914
PCW110213875(APOBEC1)
OAA100085961(APOBEC1)
APLA101792029(APOBEC1)
CATA118247605(APOBEC1)
TGU101233449
LSR110472351
SCAN103812485 103812486
PMOA120497750
OTC121340963 121340993
PRUF121349833 121349849
GFR102039999
FAB101813722 101816226
OMA130251676 130252243
PHI102100747 102100934
PMAJ107201522 107213017
CCAE111925855 111925864
CCW104690334
CBRC108447058
ETL114069346 114069369
ZAB102064430 102064599
ACHL103810518
SVG106859836
MMEA130579198 130579203
HRT120748602
FPG101914977(APOBEC1)
FCH102048970 114017759
CLV102087964 110364178
EGZ104122783
NNI104014586 104014587
PCRI104031014
PLET104620492
EHS104513938 104515546
ACUN113488778 113491289
PADL103915125 103915126
AFOR103908556(APOBEC1)
ACHC115352776 115352791
HALD104323322 104323323
HLE104836677 104836734
AGEN126047842 126047957
GCL127015935
CSTI104552269(APOBEC1)
CMAC104475585(APOBEC1)
MUI104540424 104543111
BREG104642330
FGA104081376
LDI104345795(APOBEC1)
NNT104402026 104402027
SHAB115605661 115605723
DPUB104306906(APOBEC1)
ACAR104531755(APOBEC1)
AVIT104269911(APOBEC1)
CVF104294528
RTD128903923 128904506
CUCA104060660(APOBEC1)
DNE112993833
ASN102372754 102373005 102381995
AMJ102571342(APOBEC1) 102571574(APOBEC1A) 109281895
CPOO109316287(APOBEC1)
GGN109296553(APOBEC1)
PSS102450155 102450401 102452218 102452472 112545270
CMY102933773 102943254 114018437 119567405
CCAY125623387 125623396 125623413 125623436 125633625
DCC119843884 119845090 119849529 119856517 119856527
CPIC101938253 101942380 101948688 101948965 103306514
TST117884817 117884823 117884837 117884857
CABI116823836 116823837 116823838 116823839
MRV120372170 120372216 120396934 120397411 120407049
ACS100534649(apobec1a) 103277744
ASAO132765486 132767975
SUND121920910 121922921
PBI103048122
CTIG120308764(APOBEC1)
PMUA114588078 114588080
PRAF128404783(APOBEC1)
ZVI118097952
STOW125440208
EMC129336583(APOBEC1)
BGAR122919676
MMER123562707
ATEN116291838
ADF107334541
AMIL114976299
PDAM113681034
 » show all
Reference
1  [PMID:15273326]
  Authors
Chester A, Weinreb V, Carter CW Jr, Navaratnam N
  Title
Optimization of apolipoprotein B mRNA editing by APOBEC1 apoenzyme and the role of its auxiliary factor, ACF.
  Journal
RNA 10:1399-411 (2004)
DOI:10.1261/rna.7490704
Reference
2  [PMID:10373583]
  Authors
Fujino T, Navaratnam N, Jarmuz A, von Haeseler A, Scott J
  Title
C-->U editing of apolipoprotein B mRNA in marsupials: identification and characterisation of APOBEC-1 from the American opossum Monodelphus domestica.
  Journal
Nucleic Acids Res 27:2662-71 (1999)
DOI:10.1093/nar/27.13.2662
  Sequence
[mdo:554187]
Reference
3  [PMID:8280158]
  Authors
Barnes C, Smith HC
  Title
Apolipoprotein B mRNA editing in vitro is a zinc-dependent process.
  Journal
Biochem Biophys Res Commun 197:1410-4 (1993)
DOI:10.1006/bbrc.1993.2634
Reference
4  [PMID:12881431]
  Authors
Chester A, Somasekaram A, Tzimina M, Jarmuz A, Gisbourne J, O'Keefe R, Scott J, Navaratnam N
  Title
The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay.
  Journal
EMBO J 22:3971-82 (2003)
DOI:10.1093/emboj/cdg369
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.36
IUBMB Enzyme Nomenclature: 3.5.4.36
ExPASy - ENZYME nomenclature database: 3.5.4.36
BRENDA, the Enzyme Database: 3.5.4.36

DBGET integrated database retrieval system