KEGG ENZYME: 3.5.4.37

ENZYME: 3.5.4.37

Entry

EC 3.5.4.37                 Enzyme

Name

double-stranded RNA adenine deaminase;
ADAR;
double-stranded RNA adenosine deaminase;
dsRAD;
dsRNA adenosine deaminase;
DRADA1;
double-stranded RNA-specific adenosine deaminase

Class

Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines

Sysname

double-stranded RNA adenine aminohydrolase

Reaction(IUBMB)

adenine in double-stranded RNA + H2O = hypoxanthine in double-stranded RNA + NH3 [RN:R13080]

Reaction(KEGG)

R13080

Substrate

adenine in double-stranded RNA [CPD:C22573];
H2O [CPD:C00001]

Product

hypoxanthine in double-stranded RNA [CPD:C22574];
NH3 [CPD:C00014]

Comment

This eukaryotic enzyme is involved in RNA editing. It destabilizes double-stranded RNA through conversion of adenosine to inosine. Inositol hexakisphosphate is required for activity [4].

History

EC 3.5.4.37 created 2013

Orthology

K12968

double-stranded RNA-specific adenosine deaminase

Genes

HSA:

103(ADAR)

PTR:	457349(ADAR)

PPS:	100988581(ADAR)

GGO:	101134621(ADAR)

PON:	100457633(ADAR)

NLE:	100607902(ADAR)

HMH:	116469353(ADAR)

MCC:	718759(ADAR)

MCF:	101926284(ADAR)

MTHB:

126932999

MNI:	105497976(ADAR)

CSAB:

103223917(ADAR)

CATY:

105593498(ADAR)

PANU:

101026850(ADAR)

TGE:	112618205(ADAR)

MLEU:

105544819(ADAR)

RRO:	104663489(ADAR)

TFN:	117075904(ADAR)

PTEH:

111543727(ADAR)

CANG:

105502009(ADAR)

CJC:	100386367(ADAR)

SBQ:	101031414(ADAR)

CIMI:

108292456(ADAR)

CSYR:

103250006(ADAR)

MMUR:

105873198(ADAR)

LCAT:

123634032(ADAR)

PCOQ:

105821977(ADAR)

OGA:	100941374(ADAR)

MMU:	56417(Adar)

MCAL:

110291799(Adar)

MPAH:

110320021(Adar)

RNO:	81635(Adar)

MCOC:

116093186(Adar)

ANU:	117706678(Adar)

MUN:	110562048(Adar)

CGE:	100760578(Adar)

MAUA:

101842183(Adar)

PROB:

127233035(Adar)

PLEU:

114707958(Adar)

MORG:

121450554(Adar)

MFOT:

126516145

AAMP:

119800877(Adar)

NGI:	103751329(Adar)

HGL:	101722209(Adar)

CPOC:

100731315(Adar)

CCAN:

109688036(Adar)

DORD:

105984887(Adar)

DSP:	122109246(Adar)

PLOP:

125360248(Adar)

NCAR:

124983355

MMMA:

107156744(Adar)

OCU:

100346984

OPI:	101527981(ADAR)

TUP:	102485185(ADAR)

GVR:	103608124(ADAR)

CFA:	100855668(ADAR)

CLUD:

112648962(ADAR)

VVP:	112918890(ADAR)

VLG:	121484976(ADAR)

NPO:	129509119(ADAR)

AML:	100470274(ADAR)

UMR:	103668714(ADAR)

UAH:	113245303(ADAR)

UAR:	123783391(ADAR)

ELK:

111138988

LLV:

125086092

MPUF:

101675332(ADAR)

MNP:	132025929(ADAR)

MLK:	131815090(ADAR)

NVS:	122918238(ADAR)

ORO:	101367365(ADAR)

EJU:	114198712(ADAR)

ZCA:	113932110(ADAR)

MLX:	118013854(ADAR)

NSU:	110573575(ADAR)

LWW:	102742882(ADAR)

FCA:	101084681(ADAR)

PYU:	121015666(ADAR)

PCOO:

112851718(ADAR)

PBG:	122476118(ADAR)

PVIV:

125154926(ADAR)

LRUF:

124521676

PPAD:

109256299(ADAR)

PUC:

125925735

AJU:

106988378

HHV:	120221535(ADAR)

BTA:	505134(ADAR)

BOM:	102267031(ADAR)

BBUB:

102413801(ADAR)

BBIS:

104987431(ADAR)

CHX:	102172585(ADAR)

BTAX:

128044728(ADAR)

ODA:	120855758(ADAR)

CCAD:

122432929(ADAR)

MBEZ:

129540595(ADAR)

SSC:	100523784(ADAR)

CFR:	102512737(ADAR)

CBAI:

105068180(ADAR)

CDK:	105089080(ADAR)

VPC:	102527263(ADAR)

BACU:

103018582(ADAR)

BMUS:

118896082(ADAR)

LVE:	103077270(ADAR)

OOR:	101278697(ADAR)

DLE:	111166955(ADAR)

PCAD:

102979811(ADAR)

PSIU:

116750910(ADAR)

NASI:

112401692(ADAR)

ECB:	100056984(ADAR)

EPZ:	103555415(ADAR)

EAI:	106828524(ADAR)

MYB:	102242753(ADAR)

MYD:	102754391(ADAR)

MMYO:

118672760(ADAR)

MLF:	102433169(ADAR)

PKL:	118721102(ADAR)

EFUS:

103298918(ADAR)

MNA:	107543857(ADAR)

DRO:	112316695(ADAR)

SHON:

118990185(ADAR)

AJM:	119061768(ADAR)

PDIC:

114488810(ADAR)

PHAS:

123804313(ADAR)

MMF:	118637050(ADAR)

PPAM:

129062342(ADAR)

RFQ:	117014567(ADAR)

PGIG:

120592241(ADAR)

PVP:	105296385(ADAR)

RAY:	107504718(ADAR)

MJV:	108393907(ADAR)

TOD:	119237217(ADAR)

SARA:

101553112(ADAR)

SETR:

126020695(ADAR)

TMU:

101360020

ETF:	101662936(ADAR)

DNM:	101424153(ADAR)

MDO:	100020840(ADAR)

GAS:	123247778(ADAR)

SHR:	100925968(ADAR)

AFZ:

127559850

PCW:	110211972(ADAR)

OAA:	103167888(ADAR)

GGA:	769675(ADAR)

PCOC:

116237321(ADAR)

MGP:	100541796(ADAR)

CJO:	107324489(ADAR)

TPAI:

128076609(ADAR)

LMUT:

125685837(ADAR)

NMEL:

110391260(ADAR)

APLA:

101796198(ADAR)

ACYG:

106048529(ADAR)

CATA:

118258445(ADAR)

AFUL:

116499616(ADAR)

TGU:	100220215(ADAR)

LSR:	110471526(ADAR)

SCAN:

103823962(ADAR)

PMOA:

120498974(ADAR)

OTC:	121332158(ADAR)

PRUF:

121352167(ADAR)

GFR:	102033970(ADAR)

FAB:	101806137(ADAR)

OMA:	130263191(ADAR)

PHI:	102105960(ADAR)

PMAJ:

107214561(ADAR)

CCAE:

111939463(ADAR)

CBRC:

103611252(ADAR)

ETL:	114068438(ADAR)

ZAB:	102064605(ADAR)

ACHL:

103811943(ADAR)

SVG:	106863375(ADAR)

MMEA:

130583192(ADAR)

HRT:	120764250(ADAR)

FPG:	101910869(ADAR)

FCH:	102049629(ADAR)

CLV:	102086506(ADAR)

EGZ:	104127874(ADAR)

NNI:	104012041(ADAR)

PCRI:

104032628(ADAR)

PLET:

104614193(ADAR)

EHS:

104507280

PCAO:

104044916(ADAR)

ACUN:

113490858(ADAR)

TALA:

104365296(ADAR)

PADL:

103920515(ADAR)

AFOR:

103905523(ADAR)

ACHC:

115346426(ADAR)

HALD:

104311025(ADAR)

HLE:	104829655(ADAR)

AGEN:

126040778

GCL:

127026987

CCRI:

104166054(ADAR)

CMAC:

104481405(ADAR)

BREG:

104629637(ADAR)

FGA:	104082798(ADAR)

GSTE:

104263802(ADAR)

LDI:	104354195(ADAR)

MNB:

103776625

OHA:	104338094(ADAR)

NNT:	104404326(ADAR)

SHAB:

115602570(ADAR)

PGUU:

104465650

ACAR:

104532166

CPEA:

104390604(ADAR)

AVIT:

104271810

CVF:	104290841(ADAR)

RTD:	128900922(ADAR)

CUCA:

104058107(ADAR)

TEO:	104370056(ADAR)

BRHI:

104500550(ADAR)

AAM:	106483717(ADAR)

AROW:

112973224(ADAR)

NPD:	112955220(ADAR)

TGT:	104578290(ADAR)

DNE:	112995108(ADAR)

SCAM:

104141639(ADAR)

ASN:	102377665(ADAR)

AMJ:	102575445(ADAR)

CPOO:

109324760(ADAR)

GGN:	109303498(ADAR)

PSS:	102449470(ADAR)

CMY:	102941128(ADAR)

CCAY:

125625912(ADAR)

DCC:	119847935(ADAR)

CPIC:

101936755(ADAR)

TST:	117888546(ADAR)

CABI:

116830121(ADAR)

MRV:	120390168(ADAR)

ACS:

103281753

ASAO:

132764090(ADAR)

PVT:	110081003(ADAR)

SUND:

121915309(ADAR)

PBI:	103050667(ADAR)

PMUR:

107285169(ADAR)

CTIG:

120317049(ADAR)

TSR:	106546970(ADAR)

PGUT:

117657417(ADAR)

APRI:

131186639(ADAR)

PTEX:

113452865 113452866 113452867 113452869

VKO:	123032540(ADAR)

PMUA:

114586089(ADAR)

PRAF:

128404468(ADAR)

ZVI:	118075835(ADAR)

HCG:	128336966(ADAR)

GJA:	107117082(ADAR)

EMC:	129340054(ADAR)

XLA:	394279(adar-a) 397992(adar.S)

XTR:	100493195(adar)

NPR:	108798342(ADAR)

RTEM:

120920674(ADAR)

BBUF:

120981415(ADAR)

BGAR:

122921756(ADAR)

MUO:	115456983(ADAR)

GSH:	117350477(ADAR)

DRE:	58119(adar)

SRX:	107714681 107723499

SANH:

107657642

SGH:

107582078

CCAR:

109069003

CAUA:

113059109 113116748

CGIB:

127974704 128030703

PTET:

122359966(adar)

LROH:

127178907(adar)

OMC:	131521259(adar)

PPRM:

120484300(adar)

RKG:	130101759(adar)

MAMB:

125242935(adar)

CIDE:

127497916

MASI:

127452888 127453546

TROS:

130557837(adar)

TDW:	130432719(adar)

MANU:

129447957(adar)

IPU:

108265537

IFU:	128606893(adar)

PHYP:

113545404(adar)

SMEO:

124384211(adar)

TFD:	113646833(adar)

TVC:	132846196(adar)

AMEX:

103023414(adar)

CMAO:

118823416(adar)

EEE:	113591712(adar)

CHAR:

105891921(adar)

TRU:	101073967(adar)

TFS:	130532486(adar)

LCO:	104922500(adar)

NCC:	104958853(adar)

TBEN:

117480134(adar)

CGOB:

115020800(adar)

PGEO:

117460355(adar)

GACU:

117553954(adar)

EMAC:

134861645(adar)

ELY:	117265724(adar)

EFO:	125892828(adar)

PLEP:

121945375(adar)

SLUC:

116049564(adar)

ECRA:

117946697(adar)

ESP:	116690802(adar)

PFLV:

114556855(adar)

GAT:	120810483(adar)

PPUG:

119197717(adar)

AFB:	129108995(adar)

CLUM:

117745058(adar)

PSWI:

130212778(adar)

MSAM:

119897576(adar)

SCHU:

122882168(adar)

CUD:	121513229(adar)

ALAT:

119005863(adar)

MZE:	101475397(adar)

ONL:	100707103(adar)

OAU:	116315701(adar)

OLA:	101155879(adar)

OML:	112143394(adar)

CSAI:

133432394(adar)

XMA:	102217978(adar)

XCO:	114141750(adar)

XHE:	116717193(adar)

PRET:

103478179(adar)

PFOR:

103140790(adar)

PLAI:

106962090(adar)

PMEI:

106930146(adar)

GAF:	122830951(adar)

PPRL:

129371300(adar)

CVG:	107088416(adar)

CTUL:

119786711(adar)

GMU:	124866009(adar)

NFU:	107374479(adar)

KMR:	108241070(adar)

ALIM:

106517188(adar)

NWH:	119409734(adar) 119410066

AOCE:

111582754(adar)

MCEP:

125016365(adaR)

CSEM:

103388211(adar)

POV:	109633429(adar)

SSEN:

122774816(adar)

HHIP:

117776470(adar)

HSP:	118113545(adar)

SMAU:

118301480(adar)

LCF:

108885934

SDU:	111230122(adar)

SLAL:

111656978(adar)

XGL:	120784244(adar)

HCQ:	109521078(adar)

SSCV:

125975343

SBIA:

133500882(adar)

PEE:	133401320(adar)

PTAO:

133479566(adar)

BPEC:

110162987

MALB:

109964118(adar)

BSPL:

114843501(adar)

SJO:	128366442(adar)

SASA:

106605901(adar)

STRU:

115177204 115177266

OTW:	112238065 112238838

OMY:	110520838(adar) 110534250

OGO:	123998210 124005167

ONE:

115124133

OKI:	109866698 116376524

OKE:	118373734 118373735(adar)

SALP:

112075075

SNH:	120042113 120048755

CCLU:

121542729(adar)

ELS:	105024448(adar)

SFM:	108925759(adar)

PKI:	111840888(adar)

AANG:

118224938(adar)

PSPA:

121306932(adar)

PSEX:

120535574(adar)

LCM:	102360746(ADAR)

RTP:	109912767(adar)

CPLA:

122544712(adar)

HOC:	132805587(adar)

LERI:

129715307(adar)

PMRN:

116950849(ADAR) 116954936

LRJ:	133344079 133354150 133361043

CIN:

100183336

SPU:

584058

RSAN:

119405262

RMP:

119180667

VJA:

111272658

ABRU:

129956562

UDV:

129217469

SDM:

118189760

CEL:	CELE_T20H4.4(adr-2)

CRQ:	GCK72_008630

PVUL:

126824549

CRG:	105330468 105341503

CVN:

111130123

CANU:

128176028 128176031

OED:

125649394

PMAX:

117334379

MMER:

123531101

RPHI:

132722439 132754534

DPOL:

127856227

NVE:

5508360

ATEN:

116286315

HSY:

130656587

MIS:	MICPUN_105848

» show all

Reference

1 [PMID:8144588]

Authors

Hough RF, Bass BL

Title

Purification of the Xenopus laevis double-stranded RNA adenosine deaminase.

Journal

J Biol Chem 269:9933-9 (1994)

Reference

2 [PMID:9614652]

Authors

O'Connell MA, Gerber A, Keegan LP

Title

Purification of native and recombinant double-stranded RNA-specific adenosine deaminases.

Journal

Methods 15:51-62 (1998)
DOI:10.1006/meth.1998.0605

Reference

3 [PMID:11421361]

Authors

Wong SK, Sato S, Lazinski DW

Title

Substrate recognition by ADAR1 and ADAR2.

Journal

RNA 7:846-58 (2001)
DOI:10.1017/s135583820101007x

Reference

4 [PMID:16141067]

Authors

Macbeth MR, Schubert HL, Vandemark AP, Lingam AT, Hill CP, Bass BL

Title

Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing.

Journal

Science 309:1534-9 (2005)
DOI:10.1126/science.1113150

Sequence

[hsa:104]

Other DBs

ExplorEnz - The Enzyme Database:

3.5.4.37

IUBMB Enzyme Nomenclature:

3.5.4.37

ExPASy - ENZYME nomenclature database:

3.5.4.37

BRENDA, the Enzyme Database:

3.5.4.37

DBGET integrated database retrieval system