KEGG ENZYME: 3.5.4.39

ENZYME: 3.5.4.39

Entry

EC 3.5.4.39                 Enzyme

Name

GTP cyclohydrolase IV;
MptA;
GTP cyclohydrolase MptA

Class

Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines

Sysname

GTP 7,8-8,9-dihydrolase (cyclizing, formate-releasing, diphosphate-releasing)

Reaction(IUBMB)

GTP + H2O = 7,8-dihydroneopterin 2',3'-cyclic phosphate + formate + diphosphate [RN:R10348]

Reaction(KEGG)

R10348

Substrate

GTP [CPD:C00044];
H2O [CPD:C00001]

Product

7,8-dihydroneopterin 2',3'-cyclic phosphate [CPD:C20567];
formate [CPD:C00058];
diphosphate [CPD:C00013]

Comment

Requires Fe2+. A zinc protein. The enzyme is involved in methanopterin biosynthesis in methanogenic archaea. cf. GTP cyclohydrolase I (EC 3.5.4.16), GTP cyclohydrolase II (EC 3.5.4.25) and GTP cyclohydrolase IIa (EC 3.5.4.29).

History

EC 3.5.4.39 created 2013

Pathway

ec00790

Folate biosynthesis

ec01100

Metabolic pathways

Orthology

K17488

GTP cyclohydrolase IV

Genes

DAK:	DaAHT2_1317

DHR:	LGS26_07315

HAS:	Halsa_0950

ARX:	ARZXY2_4868

TFL:	RPIT_09110

BSOL:

FSW04_24680

BALA:

DSM104299_05124(folE2)

CWO:

Cwoe_5367

PARN:

NBH00_03525(mptA)

SBAE:

DSM104329_04840(folE2)

TALU:

JDY09_08825

KBS:	EPA93_20390

TTR:

Tter_0579

VAB:

WPS_26460

AMO:	Anamo_1142

ARAM:

KAR29_10165

MJA:

MJ_0775

MFE:	Mefer_1030

MVU:	Metvu_0037

MFS:	MFS40622_1401

MIF:	Metin_0324

MJH:	JH146_1120

MESG:

MLAUSG7_0263(mptA)

MESA:

MLASG1_1411(mptA)

MIG:	Metig_1140

MMP:

MMP0034

MMQ:	MmarC5_1646

MMX:	MmarC6_0915

MMZ:	MmarC7_1031

MMD:

GYY_00175

MMAK:

MMKA1_00360

MMAO:

MMOS7_00600

MMAD:

MMJJ_10620(folE2)

MAE:

Maeo_1148

MVN:	Mevan_1031

MVO:

Mvol_1397

MOK:	Metok_0710

METF:

CFE53_06270

MTH:

MTH_1196

MMG:	MTBMA_c15740

MWO:	MWSIV6_1589(mptA)

MTEE:

MTTB_02310

METC:

MTCT_1089

METE:

tca_01153(folE2)

METZ:

METMT2_1198

METK:

FVF72_05640

MTHM:

FZP57_07615

METJ:

FZP68_03060

MST:

Msp_0294

METB:

AW729_05680

MEIS:

PXD04_05270(mptA)

MRU:	mru_1962(mptA)

MSI:

Msm_1033

MEB:	Abm4_1545(mptA)

MMIL:

sm9_2045(mptA)

MEYE:

TL18_09410

MOL:

YLM1_1409

MARO:

MarbSA_15180

METV:

K4897_06300(mptA)

MEL:	Metbo_0329

MEW:	MSWAN_2088

METH:

MBMB1_1719(mptA)

MFC:	BRM9_0972(mptA)

MFI:	DSM1535_0942(mptA)

MCUB:

MCBB_2018(mptA)

MSUB:

BK009_07600

METN:

BK008_03255

METT:

CIT01_03840

METO:

CIT02_09295

MEME:

HYG87_05120

MFEG:

GCM10025860_03280

MFV:

Mfer_0397

MKA:

MK0485

AFU:

AF_1179

AFG:	AFULGI_00012790

APO:	Arcpr_1427

AVE:	Arcve_1798

AST:	Asulf_00557

FPL:

Ferp_0754

GAC:

GACE_2009

GAH:

GAH_01203

PFU:

PF1832

PFI:

PFC_09430

PHO:	PH1783(PH1783)

PAB:

PAB0223

PYN:

PNA2_0389

PYA:	PYCH_01300

PYS:

Py04_1714

PYC:	TQ32_07820

TKO:

TK0793

TON:

TON_0757

TGA:

TGAM_1430

TSI:

TSIB_1100

TBA:	TERMP_00493

THE:

GQS_01100

THA:

TAM4_1572

THM:

CL1_1922

TLT:

OCC_00185

THS:

TES1_0675

TNU:

BD01_0945

TEU:

TEU_10520

TGY:	X802_00005

THV:	ADU37_CDS12730

TCH:	CHITON_2071

TPEP:

A0127_01125

TPIE:

A7C91_09980

TGG:	A3K92_04210

TCE:	A3L02_08360

TBS:	A3L01_04590

THH:	CDI07_04460

TSL:	A3L11_08715

TTD:	A3L14_06535

TPRF:

A3L09_06655

TRL:	A3L10_02035

TPAF:

A3L08_07365

THY:	A3L12_07875

TIC:	FH039_08850

TCQ:	TIRI35C_1173(mptA)

THEM:

FPV09_00845

THEI:

K1720_08635

PPAC:

PAP_06000

MBA:	Mbar_A1183

MBY:	MSBRM_3385

MBW:	MSBRW_3540

MBAR:

MSBR2_3338

MBAK:

MSBR3_3388

MAC:

MA_4517

MMA:

MM_1222

MMAZ:

MmTuc01_1262

MMJ:	MSMAS_0090

MMAC:

MSMAC_0096

MVC:	MSVAZ_0095

MEK:	MSKOL_0092

MLS:	MSLAZ_0132

METM:

MSMTP_0123

MEF:	MSWH1_0121

MEQ:	MSWHS_0120

MSJ:	MSSAC_4282

MSZ:	MSSIH_3787

MSW:	MSSIT_3864

MTHR:

MSTHT_1658

MTHE:

MSTHC_1631

MHOR:

MSHOH_0106

MFZ:	AOB57_007405

MBU:

Mbur_0054

MMET:

MCMEM_0637

MELO:

J7W08_01255

MMH:

Mmah_1229

MHAZ:

BHR79_07400

MPOT:

BKM01_03645

MEV:	Metev_1546

MZH:	Mzhil_0318

MPY:

Mpsy_1383

MZI:	HWN40_01845

MMAV:

RE476_08425(mptA)

MSEB:

RE474_05020(mptA)

MHZ:	Metho_0291

MEHF:

MmiHf6_13270(folE2)

MEES:

MmiEs2_15650(folE2)

MTP:

Mthe_0355

MCJ:

MCON_3313

MHI:

Mhar_1861

MHU:

Mhun_2334

MRTJ:

KHC33_15945

MLA:

Mlab_0018

MEM:	Memar_2173

MBG:	BN140_1377

MEMA:

MMAB1_1760(mptA)

MCHK:

MchiMG62_24870

MSUM:

OH143_05150(mptA)

MRC:	R6Y96_03420(mptA)

MPI:

Mpet_0589

MEND:

L6E24_05980(mptA)

MEFW:

F1737_08270

MAQE:

RJ40_08160

MFK:	E2N92_08380

MOU:	OU421_07315(mptA)

MESB:

L1S32_10720(mptA)

MANQ:

L1994_08500(mptA)

MBN:

Mboo_0480

MFO:	Metfor_2712

MPL:

Mpal_0083

MPD:	MCP_1133(mptA-1) MCP_2574(mptA-2)

MEZ:	Mtc_0027(mptA-1) Mtc_1062(mptA-2)

RCI:	LRC194 RCIX633

HAL:

VNG_1901C

HSL:	OE_3673F(mptA)

HANR:

LJ422_07650(mptA)

HDL:	HALDL1_14505

HHB:	Hhub_3237(mptA)

HAGS:

JT689_08985

HABO:

JRZ79_07390(mptA)

HNO:	LT974_12945(mptA)

HLU:	LT972_01895(mptA)

HALH:

HTSR_1822

HHSR:

HSR6_1891(mptA)

HSU:	HLASF_1932

HSF:	HLASA_1918

HAHS:

HSRCO_2558(mptA)

SALR:

FQU85_06585

HALR:

EFA46_002005

HJE:	HacjB3_03755

HDO:	MUK72_01625(mptA)

HALX:

M0R89_02555(mptA)

HAXZ:

M0R88_02535(mptA)

HAYC:

NGM10_13015(mptA)

HAXY:

NGM07_06730(mptA)

SALI:

L593_14035

SAIM:

K0C01_04145(mptA)

HARA:

AArcS_2867(mptA)

HMA:

rrnAC3309

HHI:	HAH_0546(mptA)

HHN:	HISP_02825

HAB:	SG26_10615

HTA:	BVU17_02710

HALJ:

G9465_17400

HSIN:

KDQ40_10775

NPH:	NP_2514A(mptA)

NMO:	Nmlp_1862(mptA)

NHO:	HWV23_13850

NSAL:

HWV07_15910

HUT:

Huta_2260

HTI:	HTIA_1987(mptA)

HALA:

Hrd1104_00845

HASV:

SVXHr_2314(mptA)

HABN:

HBNXHr_2307(mptA)

HMU:

Hmuk_1583

HALZ:

E5139_11040

HALL:

LC1Hm_0742(mptA)

HAZP:

GBQ70_11035

HALI:

BV210_12220

HSN:	DV733_03650

HDS:	HSR122_1579(mptA)

HRR:	HZS55_19685

HPEL:

HZS54_22605

HLT:	I7X12_15700

HARC:

HARCEL1_07315

SSAI:

N0B31_04410(mptA)

HAAD:

MW046_11965(mptA)

HWA:	HQ_3317A(mptA)

HWC:	Hqrw_3846(mptA)

HVO:	HVO_2348(folE2)

HME:

HFX_2357

HGI:	ABY42_11705

HALE:

G3A49_14955

HLS:	KU306_01495(mptA)

HLN:	SVXHx_2266(mpta)

HBO:	Hbor_07600

HAQ:	DU484_16515

HAJ:	DU500_16560

HAER:

DU502_14670

HRA:	EI982_15875

HLM:	DV707_03645

HALM:

FCF25_03475

HLA:

Hlac_2276

HALP:

DOS48_11435

HALB:

EKH57_13840

HEZZ:

EO776_12545

HALQ:

Hrr1229_009530

HSS:	J7656_03780

HSAI:

HPS36_09100

SRUB:

C2R22_16595

HAE:	halTADL_1124

HALN:

B4589_005550

HALG:

HUG10_01260

HALU:

HUG12_16135

HMP:	K6T50_14990(mptA)

HRE:	K6T36_14950(mptA)

HRM:	K6T25_01355(mptA)

HACB:

Hbl1158_07095(mptA)

HDF:	AArcSl_0007(mptA)

HAAA:

AArcCO_0007(mptA)

HAH:	Halar_1782

HTU:

Htur_0488

HSAL:

JMJ58_06730

HAKZ:

J0X25_09020(mptA)

NMG:	Nmag_2853(mptA)

HXA:	Halxa_1887

NAT:

NJ7G_0097

NPE:	Natpe_3511

NVR:	FEJ81_16925

NPL:	FGF80_15815

NAY:	HYG81_12020(mptA) HYG81_20795(mptA)

HALY:

HYG82_15840

HJT:	DVR14_07695

HLO:	J0X27_09350

NGE:	Natgr_1192

HRU:	Halru_1192

SAWL:

NGM29_02035(mptA)

HALV:

NGM15_11650(mptA)

NOU:	Natoc_0334

HLR:	HALLA_05580

HLC:	CHINAEXTREME02245

NAJ:	B1756_12675

NAG:	AArcMg_3124

NAN:	AArc1_3030

NARA:

QQ977_05115(mptA)

NBG:	DV706_08615

NAS:	GCU68_03520

HDA:	BB347_11685

MELU:

MTLP_02220

MEAM:

MU439_05335(mptA)

MEAE:

QEN48_04805(mptA)

TAC:

Ta1138

TVO:	TVG1279013(TVG1279013)

PTO:

PTO1009

CDIV:

CPM_1080

TAR:	TALC_01341

MAX:	MMALV_14310

MER:	MMINT_04030

MEAR:

Mpt1_c09750(mptA)

MEUZ:

KRP56_06970(mptA)

MARC:

AR505_0210

ABI:

Aboo_0781

ACF:	AciM339_0290

APE:

APE_2308

ACJ:

ACAM_1445

SHC:	Shell_1375

DKA:

DKAM_0427

DFD:	Desfe_0332

DMU:	Desmu_0826

TAG:

Tagg_0592

IAG:

Igag_0283

THG:	TCELL_0826

ASC:

ASAC_0336

ACIA:

SE86_02485

CLG:	Calag_0295

FFO:	FFONT_0386

CSU:	CSUB_C0906

CCAI:

NAS2_0842

KCR:

Kcr_0832

LOKI:

Lokiarch_29360(mptA)

» show all

Reference

1 [PMID:17497938]

Authors

Grochowski LL, Xu H, Leung K, White RH

Title

Characterization of an Fe(2+)-dependent archaeal-specific GTP cyclohydrolase, MptA, from Methanocaldococcus jannaschii.

Journal

Biochemistry 46:6658-67 (2007)
DOI:10.1021/bi700052a

Sequence

[mja:MJ_0775]

Other DBs

ExplorEnz - The Enzyme Database:

3.5.4.39

IUBMB Enzyme Nomenclature:

3.5.4.39

ExPASy - ENZYME nomenclature database:

3.5.4.39

BRENDA, the Enzyme Database:

3.5.4.39

DBGET integrated database retrieval system