Entry
Name
aminodeoxyfutalosine deaminase;
AFL deaminase;
aminofutalosine deaminase;
mqnX (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
6-amino-6-deoxyfutalosine deaminase
Reaction(IUBMB)
6-amino-6-deoxyfutalosine + H2O = futalosine + NH3 [RN:
R10695 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme, found in several bacterial species, is part of the futalosine pathway for menaquinone biosynthesis.
History
EC 3.5.4.40 created 2014
Pathway
ec00130 Ubiquinone and other terpenoid-quinone biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K18286 aminodeoxyfutalosine deaminase
K20810 aminodeoxyfutalosine deaminase
Genes
HSH : NHP194022_14400(add)
DML : Dmul_04740(add) Dmul_31800
EUZ : DVS28_a4285 DVS28_a4593
NAH : F5544_06340 F5544_22955
SSX : SACTE_4848 SACTE_6096
SLE : sle_20140(sle_20140)
SALL : SAZ_02725 SAZ_30510
SXT : KPP03845_105381(add2_2)
STRH : GXP74_06575 GXP74_29165(add)
NAQU : ENKNEFLB_03425(add2_1)
SRO : Sros_6019 Sros_6873 Sros_8785
FRE : Franean1_2196 Franean1_6098
FSY : FsymDg_0807 FsymDg_4011
KUT : JJ691_41990(add_1) JJ691_96670(add_4)
LED : BBK82_01670 BBK82_44150
MICB : MicB006_4944 MicB006_5310
MCRA : ID554_02550 ID554_11855(add)
MENO : Jiend_07610 Jiend_60130
ASE : ACPL_5523(add2) ACPL_6558(add2)
ACTS : ACWT_5392 ACWT_6427
AIH : Aiant_02720 Aiant_22570
ACTL : L3i22_065450 L3i22_088360
AOU : ACTOB_005220 ACTOB_006822
PSUU : Psuf_058600 Psuf_062840
ASER : Asera_12580 Asera_63930
PRY : Prubr_37020 Prubr_48300
» show all
Taxonomy
Reference
Authors
Arakawa C, Kuratsu M, Furihata K, Hiratsuka T, Itoh N, Seto H, Dairi T
Title
Diversity of the early step of the futalosine pathway.
Journal
Sequence
Reference
Authors
Goble AM, Toro R, Li X, Ornelas A, Fan H, Eswaramoorthy S, Patskovsky Y, Hillerich B, Seidel R, Sali A, Shoichet BK, Almo SC, Swaminathan S, Tanner ME, Raushel FM
Title
Deamination of 6-aminodeoxyfutalosine in menaquinone biosynthesis by distantly related enzymes.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.40
ExPASy - ENZYME nomenclature database: 3.5.4.40