KEGG   ENZYME: 3.5.99.11
Entry
EC 3.5.99.11                Enzyme                                 
Name
2-aminomuconate deaminase (2-hydroxymuconate-forming);
cnbZ (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In other compounds
Sysname
2-aminomuconate aminohydrolase [(2Z,4E)-2-hydroxyhexa-2,4-dienedioate-forming]
Reaction(IUBMB)
2-aminomuconate + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH3
Reaction(KEGG)
(other) R11532
Substrate
2-aminomuconate [CPD:C02220];
H2O [CPD:C00001]
Product
(2Z,4E)-2-hydroxyhexa-2,4-dienedioate;
NH3 [CPD:C00014]
Comment
The enzyme, characterized from the bacterium Comamonas testosteroni CNB-1, converts 2-aminomuconate to 2-hydroxyhexa-2,4-dienedioate, unlike the enzymes from Pseudomonas, which produce (3E)-2-oxohex-3-enedioate (see EC 3.5.99.5, 2-aminomuconate deaminase). The enzyme also acts on 2-amino-5-chloromuconate.
History
EC 3.5.99.11 created 2016 as EC 3.5.1.120, transferred 2017 to EC 3.5.99.11
Orthology
K20931  2-aminomuconate deaminase (2-hydroxymuconate-forming)
Reference
1  [PMID:17259310]
  Authors
Liu L, Wu JF, Ma YF, Wang SY, Zhao GP, Liu SJ
  Title
A novel deaminase involved in chloronitrobenzene and nitrobenzene degradation with Comamonas sp. strain CNB-1.
  Journal
J Bacteriol 189:2677-82 (2007)
DOI:10.1128/JB.01762-06
  Sequence
[ag:ABI49649]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.99.11
IUBMB Enzyme Nomenclature: 3.5.99.11
ExPASy - ENZYME nomenclature database: 3.5.99.11
BRENDA, the Enzyme Database: 3.5.99.11

  All links  
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (4)   
   UniProt (3)   
   SWISS-PROT (1)   
DNA sequence (4)   
   GenBank (2)   
   EMBL (2)   
All databases (16)   

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