KEGG   ENZYME: 3.6.1.76
Entry
EC 3.6.1.76                 Enzyme                                 
Name
prenyl-diphosphate phosphatase
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
Sysname
prenyl diphosphate/3-methylbut-3-en-1-yl diphosphate phosphohydrolase
Reaction(IUBMB)
(1) prenyl diphosphate + H2O = prenyl phosphate + phosphate [RN:R12896];
(2) 3-methylbut-3-en-1-yl diphosphate + H2O = 3-methylbut-3-en-1-yl phosphate + phosphate [RN:R13127]
Reaction(KEGG)
R12896 R13127
Substrate
prenyl diphosphate [CPD:C00235];
H2O [CPD:C00001];
3-methylbut-3-en-1-yl diphosphate [CPD:C00129]
Product
prenyl phosphate [CPD:C21214];
phosphate [CPD:C00009];
3-methylbut-3-en-1-yl phosphate [CPD:C20345]
Comment
The enzyme, characterized from the methanogenic archaeon Methanosarcina mazei, belongs to the Nudix hydrolase family (a superfamily of hydrolytic enzymes capable of cleaving nucleoside diphosphates linked to a moiety). Its main purpose is to provide the substrate for EC 2.5.1.129, flavin prenyltransferase.
History
EC 3.6.1.76 created 2022
Pathway
ec00740  Riboflavin metabolism
Orthology
K25520  prenyl-diphosphate phosphatase
Genes
CHYAV22_08740(idi)
PVARSH412_005664
MBAMbar_A2550
MBYMSBRM_1379
MBWMSBRW_2178
MBARMSBR2_1030
MBAKMSBR3_0335
MACMA_3484
MMAMM_2582
MMAZMmTuc01_2633
MMJMSMAS_2126
MMACMSMAC_2333
MVCMSVAZ_1476
MEKMSKOL_1420
MLSMSLAZ_1424
MEFMSWH1_1404
MEQMSWHS_3244
MSJMSSAC_3063
MSZMSSIH_2708
MSWMSSIT_2744
MTHRMSTHT_0282
MTHEMSTHC_0449
MHORMSHOH_2732
MFZAOB57_000995
 » show all
Reference
1  [PMID:34864834]
  Authors
Ishibashi Y, Matsushima N, Ito T, Hemmi H.
  Title
Isopentenyl diphosphate/dimethylallyl diphosphate-specific Nudix hydrolase from the methanogenic archaeon Methanosarcina mazei.
  Journal
Biosci Biotechnol Biochem zbab205 (2021)
DOI:10.1093/bbb/zbab205
  Sequence
[mma:MM_2582]
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.76
IUBMB Enzyme Nomenclature: 3.6.1.76
ExPASy - ENZYME nomenclature database: 3.6.1.76
BRENDA, the Enzyme Database: 3.6.1.76

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