KEGG   ENZYME: 3.6.1.77
Entry
EC 3.6.1.77                 Enzyme                                 
Name
coenzyme A diphosphatase;
CoA pyrophosphatase;
coenzyme A pyrophosphatase;
CoA diphosphohydrolase;
Nudt19;
Nudt7;
thnR (gene name)
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
Sysname
coenzyme A 4'-phosphopantetheine phosphohydrolase
Reaction(IUBMB)
coenzyme A + H2O = adenosine 3',5'-bisphosphate + 4'-phosphopantetheine
Substrate
coenzyme A [CPD:C00010];
H2O [CPD:C00001]
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
4'-phosphopantetheine [CPD:C01134]
Comment
The enzyme belongs to the Nudix hydrolase family. It has been reported from bacteria, yeast, and mammals. Activity is higher with oxidized disulfide CoA than with reduced CoA.
History
EC 3.6.1.77 created 2024
Reference
1  [PMID:11136450]
  Authors
Xu W, Shen J, Dunn CA, Desai S, Bessman MJ.
  Title
The Nudix hydrolases of Deinococcus radiodurans.
  Journal
Mol Microbiol 39:286-90 (2001)
DOI:10.1046/j.1365-2958.2001.02267.x
Reference
2  [PMID:11415433]
  Authors
Gasmi L, McLennan AG
  Title
The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives.
  Journal
Biochem J 357:33-8 (2001)
DOI:10.1042/bj3570033
  Sequence
[mmu:67528]
Reference
3  [PMID:12837785]
  Authors
Kang LW, Gabelli SB, Bianchet MA, Xu WL, Bessman MJ, Amzel LM.
  Title
Structure of a coenzyme A pyrophosphatase from Deinococcus radiodurans: a member of the Nudix family.
  Journal
J Bacteriol 185:4110-8 (2003)
DOI:10.1128/JB.185.14.4110-4118.2003
  Sequence
[dra:DR_1184]
Reference
4  [PMID:18678912]
  Authors
Freeman MF, Moshos KA, Bodner MJ, Li R, Townsend CA
  Title
Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis.
  Journal
Proc Natl Acad Sci U S A 105:11128-33 (2008)
DOI:10.1073/pnas.0804500105
  Sequence
[scy:SCATT_p08980]
Reference
5  [PMID:29378847]
  Authors
Shumar SA, Kerr EW, Geldenhuys WJ, Montgomery GE, Fagone P, Thirawatananond P, Saavedra H, Gabelli SB, Leonardi R.
  Title
Nudt19 is a renal CoA diphosphohydrolase with biochemical and regulatory properties that are distinct from the hepatic Nudt7 isoform.
  Journal
J Biol Chem 293:4134-4148 (2018)
DOI:10.1074/jbc.RA117.001358
  Sequence
[mmu:67528 110959]
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.77
IUBMB Enzyme Nomenclature: 3.6.1.77
ExPASy - ENZYME nomenclature database: 3.6.1.77
BRENDA, the Enzyme Database: 3.6.1.77

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