KEGG ENZYME: 3.7.1.24

ENZYME: 3.7.1.24

Entry

EC 3.7.1.24                 Enzyme

Name

2,4-diacetylphloroglucinol hydrolase;
PhlG

Class

Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances

Sysname

2,4-diacetylphloroglucinol acetylhydrolase

Reaction(IUBMB)

2,4-diacetylphloroglucinol + H2O = 2-acetylphloroglucinol + acetate [RN:R12392]

Reaction(KEGG)

R12392

Substrate

2,4-diacetylphloroglucinol [CPD:C21896];
H2O [CPD:C00001]

Product

2-acetylphloroglucinol [CPD:C21895];
acetate [CPD:C00033]

Comment

Requires Zn2+. Isolated from the bacteria Pseudomonas fluorescens, Pseudomonas sp. YGJ3 and Mycobacterium abscessus 103. It reduces the antibiotic activity of 2,4-diacetylphloroglucinol.

History

EC 3.7.1.24 created 2019

Orthology

K23519

2,4-diacetylphloroglucinol hydrolase

Genes

SMW:	SMWW4_v1c24760

SERF:

L085_16355

SSUR:

ATE40_009065

SNEM:

NLX84_12550

ASU:

Asuc_2081

PFL:	PFL_5952(phlG)

PPRC:

PFLCHA0_c59060(phlG)

PPRO:

PPC_5899(phlG)

PFE:	PSF113_2464(phlG)

PBA:	PSEBR_a2324

PSOS:

POS17_5894(phlG)

POJ:	PtoMrB4_28140

PBZ:	GN234_00525

PPII:

QL104_30085

PTW:	TUM18999_30710

PSOA:

PSm6_52040

AVF:	RvVAR031_07390

THD:	BHV28_04310(phlG)

AGAT:

RWV98_05475

ETM:	CE91St48_04080 CE91St48_17750

MBOK:

MBOE_23580

MAB:

MAB_4487c

GAM:	GII34_21285

GPD:	GII33_20935

DTM:	BJL86_2542

SMAL:

SMALA_7692

SSOI:

I1A49_42260

STRE:

GZL_08194

SYUN:

MOV08_38030

FLG:	LV716_08325

» show all

Reference

1 [PMID:16391073]

Authors

Bottiglieri M, Keel C

Title

Characterization of PhlG, a hydrolase that specifically degrades the antifungal compound 2,4-diacetylphloroglucinol in the biocontrol agent Pseudomonas fluorescens CHA0.

Journal

Appl Environ Microbiol 72:418-27 (2006)
DOI:10.1128/AEM.72.1.418-427.2006

Reference

2 [PMID:20018877]

Authors

He YX, Huang L, Xue Y, Fei X, Teng YB, Rubin-Pitel SB, Zhao H, Zhou CZ

Title

Crystal structure and computational analyses provide insights into the catalytic mechanism of 2,4-diacetylphloroglucinol hydrolase PhlG from Pseudomonas fluorescens.

Journal

J Biol Chem 285:4603-11 (2010)
DOI:10.1074/jbc.M109.044180

Sequence

[pfl:PFL_5952]

Reference

3 [PMID:22790955]

Authors

Saitou H, Watanabe M, Maruyama K

Title

Molecular and catalytic properties of 2,4-diacetylphloroglucinol hydrolase (PhlG) from Pseudomonas sp. YGJ3.

Journal

Biosci Biotechnol Biochem 76:1239-41 (2012)
DOI:10.1271/bbb.120054

Sequence

[ag:BAK39611]

Reference

4 [PMID:25664803]

Authors

Zhang Z, Jiang YL, Wu Y, He YX

Title

Crystallization and preliminary X-ray diffraction analysis of a putative carbon-carbon bond hydrolase from Mycobacterium abscessus 103.

Journal

Acta Crystallogr F Struct Biol Commun 71:239-42 (2015)
DOI:10.1107/S2053230X15001612

Sequence

[mab:MAB_4487c]

Other DBs

ExplorEnz - The Enzyme Database:

3.7.1.24

IUBMB Enzyme Nomenclature:

3.7.1.24

ExPASy - ENZYME nomenclature database:

3.7.1.24

BRENDA, the Enzyme Database:

3.7.1.24

All links

Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (38)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (32)   
   KEGG MGENES (5)   
Protein sequence (8)   
   UniProt (4)   
   SWISS-PROT (4)   
Protein domain (1)   
   InterPro (1)   
All databases (54)   

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