KEGG ENZYME: 3.7.1.25

ENZYME: 3.7.1.25

Entry

EC 3.7.1.25                 Enzyme

Name

2-hydroxy-6-oxohepta-2,4-dienoate hydrolase;
todF (gene name)

Class

Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances

Sysname

(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate acetylhydrolase

Reaction(IUBMB)

(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + acetate

Reaction(KEGG)

(other) R05138

Substrate

(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate;
H2O [CPD:C00001]

Product

(2Z)-2-hydroxypenta-2,4-dienoate;
acetate [CPD:C00033]

Comment

A bacterial enzyme that participates in the degradation of toluene and 2-nitrotoluene.

History

EC 3.7.1.25 created 2019

Pathway

ec00622

Xylene degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K10702

2-hydroxy-6-oxohepta-2,4-dienoate hydrolase

Genes

PPF:

Pput_2882

PPX:	T1E_4265(todF)

PMON:

X969_10925

PMOT:

X970_10580

PASI:

LG197_17445(todF)

BPT:

Bpet3737

ATEM:

PQV96_18715

Reference

1 [PMID:1856161]

Authors

Kukor JJ, Olsen RH

Title

Genetic organization and regulation of a meta cleavage pathway for catechols produced from catabolism of toluene, benzene, phenol, and cresols by Pseudomonas pickettii PKO1.

Journal

J Bacteriol 173:4587-94 (1991)
DOI:10.1128/jb.173.15.4587-4594.1991

Reference

2 [PMID:1916282]

Authors

Menn FM, Zylstra GJ, Gibson DT

Title

Location and sequence of the todF gene encoding 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase in Pseudomonas putida F1.

Journal

Gene 104:91-4 (1991)
DOI:10.1016/0378-1119(91)90470-V

Sequence

[ppf:Pput_2882]

Reference

3 [PMID:7944378]

Authors

Haigler BE, Wallace WH, Spain JC

Title

Biodegradation of 2-nitrotoluene by Pseudomonas sp. strain JS42.

Journal

Appl Environ Microbiol 60:3466-9 (1994)
DOI:10.1128/AEM.60.9.3466-3469.1994

Other DBs

ExplorEnz - The Enzyme Database:

3.7.1.25

IUBMB Enzyme Nomenclature:

3.7.1.25

ExPASy - ENZYME nomenclature database:

3.7.1.25

BRENDA, the Enzyme Database:

3.7.1.25

DBGET integrated database retrieval system