KEGG   ENZYME: 3.8.1.6
Entry
EC 3.8.1.6                  Enzyme                                 
Name
4-chlorobenzoate dehalogenase;
halobenzoate dehalogenase
Class
Hydrolases;
Acting on halide bonds;
In carbon-halide compounds
Sysname
4-chlorobenzoate chlorohydrolase
Reaction(IUBMB)
4-chlorobenzoate + H2O = 4-hydroxybenzoate + chloride [RN:R01307]
Reaction(KEGG)
R01307
Substrate
4-chlorobenzoate [CPD:C02370];
H2O [CPD:C00001]
Product
4-hydroxybenzoate [CPD:C00156];
chloride [CPD:C00698]
Comment
Catalyses the first step in the degradation of chlorobenzoate in Pseudomonas. In many microorganisms, this activity comprises three separate enzymes, EC 6.2.1.33 (4-chlorobenzoate---CoA ligase), EC 3.8.1.7 (4-chlorobenzoyl-CoA dehalogenase) and EC 3.1.2.23 (4-hydroxybenzoyl-CoA thioesterase).
History
EC 3.8.1.6 created 1989, modified 1999
Reference
1  [PMID:6497878]
  Authors
Muller R, Thiele J, Klages U, Lingens F.
  Title
Incorporation of [18O]water into 4-hydroxybenzoic acid in the reaction of 4-chlorobenzoate dehalogenase from pseudomonas spec. CBS 3.
  Journal
Biochem Biophys Res Commun 124:178-82 (1984)
DOI:10.1016/0006-291X(84)90933-1
Reference
2  [PMID:18889931]
  Authors
HEPPEL LA, PORTERFIELD VT
  Title
Enzymatic dehalogenation of certain brominated and chlorinated compounds.
  Journal
J Biol Chem 176:763-9 (1948)
Other DBs
ExplorEnz - The Enzyme Database: 3.8.1.6
IUBMB Enzyme Nomenclature: 3.8.1.6
ExPASy - ENZYME nomenclature database: 3.8.1.6
BRENDA, the Enzyme Database: 3.8.1.6
CAS: 94047-11-7

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Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Protein sequence (15)   
   UniProt (1)   
   PDBSTR (7)   
   PMD (7)   
DNA sequence (2)   
   GenBank (1)   
   EMBL (1)   
3D Structure (3)   
   PDB (3)   
Protein domain (1)   
   PROSITE(DOC) (1)   
All databases (28)   

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