Entry
Name
(R)-2-haloacid dehalogenase;
2-haloalkanoic acid dehalogenase[ambiguous];
2-haloalkanoid acid halidohydrolase[ambiguous];
D-2-haloacid dehalogenase;
D-DEX
Class
Hydrolases;
Acting on halide bonds;
In carbon-halide compounds
BRITE hierarchy
Sysname
(R)-2-haloacid halidohydrolase
Reaction(IUBMB)
(R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide [RN:
R07308 ]
Reaction(KEGG)
Substrate
Product
Comment
Acts on acids of short chain lengths, C2 to C4, with inversion of configuration at C-2. [See also EC
3.8.1.2 (S)-2-haloacid dehalogenase, EC
3.8.1.10 2-haloacid dehalogenase (configuration-inverting) and EC
3.8.1.11 2-haloacid dehalogenase (configuration-retaining)]
History
EC 3.8.1.9 created 2003
Reference
Authors
Smith JM, Harrison K, Colby J.
Title
Purification and characterization of D-2-haloacid dehalogenase from Pseudomonas putida strain AJ1/23.
Journal
Reference
2
Authors
Leigh, J.A., Skinner, A.J. and Cooper, R.A.
Title
Partial purification, stereospecificity and stoichiometry of three dehalogenases from a Rhizobium species.
Journal
FEMS Microbiol Lett 49:353-356 (1988)
Reference
3
Authors
Soda, K., Kurihara, T., Liu, J.-Q., Nardi-Dei, V., Park, C., Miyagi, M., Tsunasawa, S. and Esaki, N.
Title
Bacterial 2-haloacid dehalogenases: Structures and catalytic properties.
Journal
Pure Appl Chem 68:2097-2103 (1996)
Other DBs
ExplorEnz - The Enzyme Database: 3.8.1.9
ExPASy - ENZYME nomenclature database: 3.8.1.9
BRENDA, the Enzyme Database: 3.8.1.9