KEGG ENZYME: 4.1.1.102

ENZYME: 4.1.1.102

Entry

EC 4.1.1.102                Enzyme

Name

phenacrylate decarboxylase;
FDC1 (gene name);
ferulic acid decarboxylase

Class

Lyases;
Carbon-carbon lyases;
Carboxy-lyases

Sysname

3-phenylprop-2-enoate carboxy-lyase

Reaction(IUBMB)

(1) 4-coumarate = 4-vinylphenol + CO2 [RN:R02952];
(2) trans-cinnamate = styrene + CO2 [RN:R11070];
(3) ferulate = 4-vinylguaiacol + CO2 [RN:R11071]

Reaction(KEGG)

R02952 R11070 R11071;
(other) R03367

Substrate

4-coumarate [CPD:C00811];
trans-cinnamate [CPD:C00423];
ferulate [CPD:C01494]

Product

4-vinylphenol [CPD:C05627];
CO2 [CPD:C00011];
styrene [CPD:C07083];
4-vinylguaiacol [CPD:C17883]

Comment

The enzyme, found in fungi, catalyses the decarboxylation of phenacrylic acids present in plant cell walls. It requires a prenylated flavin cofactor that is produced by EC 2.5.1.129, flavin prenyltransferase.

History

EC 4.1.1.102 created 2015

Pathway

ec00940

Phenylpropanoid biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K20039

phenacrylate decarboxylase

Genes

PXY:

105396714

SCE:	YDR539W(FDC1)

SEUB:

DI49_4416

SPAO:

SPAR_D07100

ZRO:	ZYRO0E10428g

ZMK:	HG535_0A09030

DHA:	DEHA2G00682g

CAL:	CAALFM_C603620CA(CaO19.5730)

CDU:	CD36_64160

FGR:	FGSG_04669 FGSG_06434

FPU:	FPSE_08154

FVN:	FVRRES_04320 FVRRES_04750 FVRRES_11088

FVR:	FVEG_03405 FVEG_05792 FVEG_10483 FVEG_11829

FOX:	FOXG_02622 FOXG_04719 FOXG_13395 FOXG_14356 FOXG_15126

NHE:	NECHADRAFT_52948 NECHADRAFT_55997 NECHADRAFT_73218 NECHADRAFT_81268

FFC:	NCS54_00354700 NCS54_00475600 NCS54_01378600 NCS54_01495600

FKR:	NCS57_00360500 NCS57_00826100 NCS57_01359200

FMU:	J7337_001959 J7337_006326 J7337_007476(FDC1)

MAW:

MAC_08104

MAJ:	MAA_01631 MAA_06752

PLJ:	VFPFJ_04155

PTKZ:

JDV02_004665(FDC1)

CFJ:	CFIO01_10372

CLUP:

CLUP02_14534

CHIG:

CH63R_09745

SAPO:

SAPIO_CDS7959

ELA:	UCREL1_1236

PFY:	PFICI_01973 PFICI_11103

BFU:	BCIN_15g05150

ANI:	ANIA_07164

NFI:	NFIA_026010

AOR:	AO090001000093 AO090003000424

ANG:	An03g06590 An09g00030

AFV:	AFLA_001267 AFLA_008428

ALUC:

AKAW2_51012A(FDC1)

ACHE:

ACHE_80178A(FDC1)

APUU:

APUU_80780S(FDC1)

PCS:	N7525_005872

PDP:	PDIP_44190

TRG:	TRUGW13939_02308 TRUGW13939_08274

BZE:	COCCADRAFT_30049

BSC:	COCSADRAFT_160246

BOR:	COCMIDRAFT_29078

NPA:	UCRNP2_4413

CNE:

CNH00230

CNG:	CNAG_03519

CGI:	CGB_G5620W CGB_H0280W

CDEU:

CNBG_2095 CNBG_2505

MPR:	MPER_02256

MRR:	Moror_16770

SGRA:

EX895_001061

PSOJ:

PHYSODRAFT_258069

» show all

Reference

1 [PMID:20471595]

Authors

Mukai N, Masaki K, Fujii T, Kawamukai M, Iefuji H

Title

PAD1 and FDC1 are essential for the decarboxylation of phenylacrylic acids in Saccharomyces cerevisiae.

Journal

J Biosci Bioeng 109:564-9 (2010)
DOI:10.1016/j.jbiosc.2009.11.011

Sequence

[sce:YDR539W]

Reference

2 [PMID:25862228]

Authors

Bhuiya MW, Lee SG, Jez JM, Yu O

Title

Structure and Mechanism of Ferulic Acid Decarboxylase (FDC1) from Saccharomyces cerevisiae.

Journal

Appl Environ Microbiol 81:4216-23 (2015)
DOI:10.1128/AEM.00762-15

Sequence

[sce:YDR539W]

Reference

3 [PMID:26083754]

Authors

Payne KA, White MD, Fisher K, Khara B, Bailey SS, Parker D, Rattray NJ, Trivedi DK, Goodacre R, Beveridge R, Barran P, Rigby SE, Scrutton NS, Hay S, Leys D

Title

New cofactor supports alpha,beta-unsaturated acid decarboxylation via 1,3-dipolar cycloaddition.

Journal

Nature 522:497-501 (2015)
DOI:10.1038/nature14560

Sequence

[sce:YDR539W] [cdu:CD36_64160] [ang:An03g06590]

Other DBs

ExplorEnz - The Enzyme Database:

4.1.1.102

IUBMB Enzyme Nomenclature:

4.1.1.102

ExPASy - ENZYME nomenclature database:

4.1.1.102

BRENDA, the Enzyme Database:

4.1.1.102

DBGET integrated database retrieval system