KEGG ENZYME: 4.1.1.103

ENZYME: 4.1.1.103

Entry

EC 4.1.1.103                Enzyme

Name

gamma-resorcylate decarboxylase;
graF (gene name);
tsdA (gene name)

Class

Lyases;
Carbon-carbon lyases;
Carboxy-lyases

Sysname

2,6-dihydroxybenzoate carboxy-lyase

Reaction(IUBMB)

2,6-dihydroxybenzoate = 1,3-dihydroxybenzene + CO2 [RN:R11353]

Reaction(KEGG)

R11353

Substrate

2,6-dihydroxybenzoate [CPD:C21298]

Product

1,3-dihydroxybenzene [CPD:C01751];
CO2 [CPD:C00011]

Comment

The enzyme, characterized from several bacterial strains, is involved in the degradation of gamma-resorcylate. It contains a zinc ion and a water molecule at the active site. The reaction is reversible, but equilibrium greatly favors the decarboxylation reaction.

History

EC 4.1.1.103 created 2016

Pathway

ec00362

Benzoate degradation

ec01120

Microbial metabolism in diverse environments

Orthology

K20941

gamma-resorcylate decarboxylase

Genes

KPN:

KPN_04278

KPU:

KP1_0140

KPM:	KPHS_01250

KPP:

A79E_4910

KPZ:	KPNIH27_00690

KPV:	KPNIH29_00645

KPY:	KPNIH31_00680

KPG:	KPNIH32_00680

KPT:	VK055_3197

KPO:	KPN2242_24405

KPR:

KPR_0232

KPJ:

N559_5007

KPI:	D364_21795

KPA:	KPNJ1_05316

KPX:	PMK1_01765

KPB:	FH42_17750

KPNK:

BN49_4581

KVA:

Kvar_4950

KPE:

KPK_5401

KPK:	A593_11495 A593_25530

KVD:	KR75_08920 KR75_23450

KVQ:	SP68_15515

EAE:

EAE_07765

EAR:

CCG32448

KQV:	B8P98_26905

KLW:	DA718_28460

KAR:	LGL98_24275

KGR:	JJJ10_26780

KLM:	BWI76_01050

EBT:	EBL_c04090 EBL_c36970

YRE:	HEC60_06115

SNEV:

OI978_03945

OOI:	A6A10_07195

PAET:

NCTC13378_01191

PFN:	HZ99_26470

AGU:

AS4_34920

NZL:	D0T92_00825

CHRO:

CXB49_05340

CNC:	CNE_BB1p12860

BTE:	BTH_II2163

BTQ:

BTQ_5450

BTJ:

BTJ_4106

BTZ:

BTL_4919

BTV:

BTHA_5304

BTHE:

BTN_4575

BTHM:

BTRA_4840

BTHA:

DR62_4685

BTHL:

BG87_4907

BUR:	Bcep18194_B0258 Bcep18194_B3061

BSEM:

WJ12_23745

BUG:	BC1001_0585

BGF:	BC1003_5621

BGD:	bgla_2g12820 bgla_2g18650

BGO:	BM43_4095 BM43_4940 BM43_5584

BPX:	BUPH_04475 BUPH_06045

BUZ:	AYM40_28680

PCAF:

DSC91_006830

PMEG:

FNZ07_08830 FNZ07_23620

PEW:	KZJ38_16725 KZJ38_23645

PBRY:

NDK50_34235

PPAI:

E1956_34520 E1956_44095 E1956_45025

PPK:	U875_17320

PPNO:

DA70_09465

PPNM:

LV28_21345

PRB:	X636_17095

TVL:	FAZ95_22880 FAZ95_26345

PUD:	G9Q38_01855(tsdA)

POL:

Bpro_2061

AAA:

Acav_4140

VAP:	Vapar_5311

VPE:	Varpa_5099

ESJ:	SJ05684_b42850

ATU:

Atu2529

AGR:	AGROH133_08584

ATF:	Ach5_23980

ASAL:

CFBP5507_11360(tsdA)

ACUC:

KZ699_11065(tsdA)

ALEG:

CFBP4996_11010(tsdA) CFBP4996_29015

REP:	IE4803_PC00118

REI:	IE4771_PD00118

RLE:

pRL120216

RLT:	Rleg2_5726

RLB:	RLEG3_09695

RLU:	RLEG12_02380

RHK:	Kim5_PC00121

RAD:	CO657_29290

ROY:	G3A56_13315(tsdA)

RII:	FFM53_025675(tsdA)

RHID:

FFM81_029540(tsdA)

RBQ:	J2J99_28410(tsdA)

RRG:	J3P73_26395(tsdA)

RAW:	NE851_32200(tsdA)

RLW:	RlegWSM1455_24575(tsdA)

RCT:	PYR68_15385(tsdA)

ARA:

Arad_7160

ARO:	B0909_00295

RBW:	RLCC275e_24325(tsdA)

BJU:	BJ6T_69740

BIC:	LMTR13_14520

BRK:	CWS35_17235

BARH:

WN72_15315

BSEP:

HAP48_0029910

BRAZ:

LRP30_11865

MSL:

Msil_3500

RHZ:	RHPLAN_03690

MHEY:

H2LOC_012560

MIWA:

SS37A_30860

PSIN:

CAK95_00325 CAK95_04800

BND:	KWG56_11005

SULD:

B5M07_18650

SPPH:

KFK14_16355

MRM:	A7982_04688

BSS:	BSUW23_03505

BIT:	BIS30_14060

BHT:	DIC78_06360

BMOJ:

HC660_07340

BTEQ:

G4P54_03755

BCAB:

EFK13_03990

CRW:	CROST_012800

CFB:	CLFE_027800 CLFE_035600

CAUN:

CLAUR_002400 CLAUR_016060

ETM:	CE91St48_26700

EGD:	GS424_016950

MSEN:

K3U95_01950

MMV:	MYCMA_05870

MABB:

MASS_3600

MABL:

MMASJCM_3590

MIZ:	BAB75_20445

NTP:	CRH09_29575

NAH:	F5544_30755

RHA:	RHA1_ro01859

ROA:	Pd630_LPD04622

PDEF:

P9209_13405

TPR:

Tpau_1503

SOV:	QZH56_00915 QZH56_35755

STRI:

C7M71_027605

BEI:	GCM100_26200

BCAU:

I6G59_14590

SGRG:

L0C25_05405

ARHD:

VSH64_00880 VSH64_20525

KUT:	JJ691_13280

SACE:

GIY23_22490

GLJ:

GKIL_0975

OLE:	K0B96_14710

» show all

Reference

1 [PMID:15466039]

Authors

Yoshida M, Fukuhara N, Oikawa T

Title

Thermophilic, reversible gamma-resorcylate decarboxylase from Rhizobium sp. strain MTP-10005: purification, molecular characterization, and expression.

Journal

J Bacteriol 186:6855-63 (2004)
DOI:10.1128/JB.186.20.6855-6863.2004

Sequence

[ag:BAD54753]

Reference

2 [PMID:15474471]

Authors

Ishii Y, Narimatsu Y, Iwasaki Y, Arai N, Kino K, Kirimura K

Title

Reversible and nonoxidative gamma-resorcylic acid decarboxylase: characterization and gene cloning of a novel enzyme catalyzing carboxylation of resorcinol, 1,3-dihydroxybenzene, from Rhizobium radiobacter.

Journal

Biochem Biophys Res Commun 324:611-20 (2004)
DOI:10.1016/j.bbrc.2004.09.091

Reference

3 [PMID:16683134]

Authors

Matsui T, Yoshida T, Yoshimura T, Nagasawa T

Title

Regioselective carboxylation of 1,3-dihydroxybenzene by 2,6-dihydroxybenzoate decarboxylase of Pandoraea sp. 12B-2.

Journal

Appl Microbiol Biotechnol 73:95-102 (2006)
DOI:10.1007/s00253-006-0437-z

Reference

4 [PMID:16963440]

Authors

Goto M, Hayashi H, Miyahara I, Hirotsu K, Yoshida M, Oikawa T

Title

Crystal structures of nonoxidative zinc-dependent 2,6-dihydroxybenzoate (gamma-resorcylate) decarboxylase from Rhizobium sp. strain MTP-10005.

Journal

J Biol Chem 281:34365-73 (2006)
DOI:10.1074/jbc.M607270200

Reference

5 [PMID:26319878]

Authors

Kasai D, Araki N, Motoi K, Yoshikawa S, Iino T, Imai S, Masai E, Fukuda M

Title

gamma-Resorcylate catabolic-pathway genes in the soil actinomycete Rhodococcus jostii RHA1.

Journal

Appl Environ Microbiol 81:7656-65 (2015)
DOI:10.1128/AEM.02422-15

Sequence

[rha:RHA1_ro01859]

Other DBs

ExplorEnz - The Enzyme Database:

4.1.1.103

IUBMB Enzyme Nomenclature:

4.1.1.103

ExPASy - ENZYME nomenclature database:

4.1.1.103

BRENDA, the Enzyme Database:

4.1.1.103

DBGET integrated database retrieval system