KEGG ENZYME: 4.1.1.107

KEGG

ENZYME: 4.1.1.107

Entry

EC 4.1.1.107                Enzyme

Name

3,4-dihydroxyphenylacetaldehyde synthase;
DHPAA synthase

Class

Lyases;
Carbon-carbon lyases;
Carboxy-lyases

Sysname

L-dopa carboxy-lyase (oxidative-deaminating)

Reaction(IUBMB)

L-dopa + O2 + H2O = 3,4-dihydroxyphenylacetaldehyde + CO2 + NH3 + H2O2 [RN:R11916]

Reaction(KEGG)

Substrate

L-dopa [CPD:C00355];
O2 [CPD:C00007];
H2O [CPD:C00001]

Product

3,4-dihydroxyphenylacetaldehyde [CPD:C04043];
CO2 [CPD:C00011];
NH3 [CPD:C00014];
H2O2 [CPD:C00027]

Comment

A pyridoxal 5'-phosphate protein. The enzyme, isolated from the mosquito Aedes aegypti, catalyses the production of 3,4-dihydroxylphenylacetaldehyde directly from L-dopa. Dopamine is not formed as an intermediate (cf. EC 4.1.1.28, aromatic-L-amino-acid decarboxylase). The enzyme is specific for L-dopa and does not react with other aromatic amino acids with the exception of a low activity with alpha-methyl-L-dopa.

History

EC 4.1.1.107 created 2017

Pathway

Tyrosine metabolism

Metabolic pathways

Orthology

3,4-dihydroxyphenylacetaldehyde synthase

Genes

DME:	Dmel_CG10501(amd)

DER:

6549501

DSE:

6614648

DSI:	Dsimw501_GD24184(Dsim_amd)

DYA:	Dyak_GE13232

DAN:

6497523

DSR:

110181428

DPO:	117183959 4816707

DPE:	6597981 6597983

DMN:	108161124 117189005

DWI:

6644459

DGR:

6566401

DMO:	Dmoj_GI13977

DAZ:

108611006

DNV:

108658087

DHE:

111600249

DVI:

6634249

101454786 101462480

BOD:	106615364 106616425

BDR:

105234241

RZE:	108357276 108373418

AOQ:	129247758 129249055

TDA:	119669327 119669339

MDE:

101888467

106085354

LCQ:

111685139

LSQ:

119607392

GFS:

119633999

129952686

129612371 129612388

HIS:

119650590

120959634

120904565

121596486

118509868

125761934

128304215

118456735

AAG:

5573809

109404823 109423887

CQU:	CpipJ_CPIJ013308

120415581

CNS:	116343658 116343942

119072247 119072248 119074606

FVI:

122530682

106649945 106654040

LHT:

122507894

LBD:

127280085

123272459

FAS:

105273510

DAM:

107038037

122411083

DSM:

124406067

NPT:

124211561

NFB:

124175186

NLO:

107222836

NVG:

124299326

SOY:

115875383

126743569

123310893

AGB:

108909329

108739719 108739728 108739729 112904224

116172347

115445053 115445067

112044897 112044903

NIQ:

126781437

VCD:

124531045

123669476

111000456

PBX:	123712644 123717189

125055208 125056578

123705880

HZE:

124646041

OFU:	114354472 114354577

PGW:	126367712 126367723

113372214

123305198

DCI:	103513799 108252376

MQU:	128999625 128999637

IEL:

124165590

Reference

1 [PMID:21283636]

Authors

Vavricka C, Han Q, Huang Y, Erickson SM, Harich K, Christensen BM, Li J

Title

From L-dopa to dihydroxyphenylacetaldehyde: a toxic biochemical pathway plays a vital physiological function in insects.

Journal

PLoS One 6:e16124 (2011)
DOI:10.1371/journal.pone.0016124

Sequence

Other DBs

ExplorEnz - The Enzyme Database:

IUBMB Enzyme Nomenclature:

ExPASy - ENZYME nomenclature database:

BRENDA, the Enzyme Database:

DBGET integrated database retrieval system