KEGG   ENZYME: 4.1.1.108
Entry
EC 4.1.1.108                Enzyme                                 
Name
4-hydroxyphenylacetaldehyde synthase;
TYRDC-2 (gene name)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
L-tyrosine carboxy-lyase (oxidative-deaminating)
Reaction(IUBMB)
L-tyrosine + O2 + H2O = (4-hydroxyphenyl)acetaldehyde + CO2 + NH3 + H2O2 [RN:R11917]
Reaction(KEGG)
R11917
Substrate
L-tyrosine [CPD:C00082];
O2 [CPD:C00007];
H2O [CPD:C00001]
Product
4-hydroxyphenylacetaldehyde [CPD:C03765];
CO2 [CPD:C00011];
NH3 [CPD:C00014];
H2O2 [CPD:C00027]
Comment
A pyridoxal 5'-phosphate protein. The enzyme, isolated from the the plant Petroselinum crispum (parsley), catalyses the production of 4-hydroxyphenylacetaldehyde directly from L-tyrosine. Tyramine is not formed as an intermediate. The enzyme has a low activity with L-dopa (cf. EC 4.1.1.107, 3,4-dihydroxyphenylacetaldehyde synthase).
History
EC 4.1.1.108 created 2017
Pathway
ec00350  Tyrosine metabolism
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K22327  4-hydroxyphenylacetaldehyde synthase
Reference
1  [PMID:22266321]
  Authors
Torrens-Spence MP, Gillaspy G, Zhao B, Harich K, White RH, Li J
  Title
Biochemical evaluation of a parsley tyrosine decarboxylase results in a novel 4-hydroxyphenylacetaldehyde synthase enzyme.
  Journal
Biochem Biophys Res Commun 418:211-6 (2012)
DOI:10.1016/j.bbrc.2011.12.124
  Sequence
[ag:AAA33860]
Reference
2  [PMID:23204519]
  Authors
Torrens-Spence MP, Liu P, Ding H, Harich K, Gillaspy G, Li J
  Title
Biochemical evaluation of the decarboxylation and decarboxylation-deamination activities of plant aromatic amino acid decarboxylases.
  Journal
J Biol Chem 288:2376-87 (2013)
DOI:10.1074/jbc.M112.401752
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.108
IUBMB Enzyme Nomenclature: 4.1.1.108
ExPASy - ENZYME nomenclature database: 4.1.1.108
BRENDA, the Enzyme Database: 4.1.1.108

  All links  
Pathway (8)   
   KEGG PATHWAY (8)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (2)   
Protein domain (6)   
   InterPro (6)   
All databases (29)   

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