KEGG ENZYME: 4.1.1.110

ENZYME: 4.1.1.110

Entry

EC 4.1.1.110                Enzyme

Name

bisphosphomevalonate decarboxylase;
mevalonate 3,5-bisphosphate decarboxylase

Class

Lyases;
Carbon-carbon lyases;
Carboxy-lyases

Sysname

(R)-3,5-bisphosphomevalonate carboxy-lyase (isopentenyl-phosphate-forming)

Reaction(IUBMB)

(R)-3,5-bisphosphomevalonate = isopentenyl phosphate + CO2 + phosphate [RN:R10781]

Reaction(KEGG)

R10781

Substrate

(R)-3,5-bisphosphomevalonate [CPD:C20848]

Product

isopentenyl phosphate [CPD:C20345];
CO2 [CPD:C00011];
phosphate [CPD:C00009]

Comment

The enzyme participates in an alternative mevalonate pathway that takes place in extreme acidophiles of the Thermoplasmatales order. cf. EC 4.1.1.99, phosphomevalonate decarboxylase.

History

EC 4.1.1.110 created 2018

Pathway

ec00900

Terpenoid backbone biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K22813

bisphosphomevalonate decarboxylase

Genes

TAC:

Ta0893

TVO:	TVG0411662(TVG0411662)

PTO:

PTO0478

FAC:	FACI_IFERC01G1792

FAI:

FAD_0762

CDIV:

CPM_0958

MARH:

Mia14_0535

MIY:	Micr_00574

Reference

1 [PMID:28004831]

Authors

Vinokur JM, Cummins MC, Korman TP, Bowie JU

Title

An Adaptation To Life In Acid Through A Novel Mevalonate Pathway.

Journal

Sci Rep 6:39737 (2016)
DOI:10.1038/srep39737

Sequence

[tac:Ta0893]

Other DBs

ExplorEnz - The Enzyme Database:

4.1.1.110

IUBMB Enzyme Nomenclature:

4.1.1.110

ExPASy - ENZYME nomenclature database:

4.1.1.110

BRENDA, the Enzyme Database:

4.1.1.110

DBGET integrated database retrieval system