KEGG   ENZYME: 4.1.1.113
Entry
EC 4.1.1.113                Enzyme                                 
Name
trans-aconitate decarboxylase;
TAD1 (gene name)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
trans-aconitate carboxy-lyase (itaconate-forming)
Reaction(IUBMB)
trans-aconitate = itaconate + CO2 [RN:R11749]
Reaction(KEGG)
R11749
Substrate
trans-aconitate [CPD:C02341]
Product
itaconate [CPD:C00490];
CO2 [CPD:C00011]
Comment
The enzyme, characterized from the smut fungus Ustilago maydis, is involved in an alternative pathway for the biosynthesis of itaconate. cf. EC 4.1.1.6, cis-aconitate decarboxylase.
History
EC 4.1.1.113 created 2018
Pathway
ec00660  C5-Branched dibasic acid metabolism
ec01100  Metabolic pathways
Orthology
K22004  trans-aconitate decarboxylase
Genes
UMA: UMAG_05076
SGRA: EX895_003189
Reference
1  [PMID:26639528]
  Authors
Geiser E, Przybilla SK, Friedrich A, Buckel W, Wierckx N, Blank LM, Bolker M
  Title
Ustilago maydis produces itaconic acid via the unusual intermediate trans-aconitate.
  Journal
Microb Biotechnol 9:116-26 (2016)
DOI:10.1111/1751-7915.12329
  Sequence
[uma:UMAG_05076]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.113
IUBMB Enzyme Nomenclature: 4.1.1.113
ExPASy - ENZYME nomenclature database: 4.1.1.113
BRENDA, the Enzyme Database: 4.1.1.113

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (2)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (4)   
   InterPro (4)   
All databases (18)   

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