KEGG ENZYME: 4.1.1.82

ENZYME: 4.1.1.82

Entry

EC 4.1.1.82                 Enzyme

Name

phosphonopyruvate decarboxylase;
3-phosphonopyruvate carboxy-lyase

Class

Lyases;
Carbon-carbon lyases;
Carboxy-lyases

Sysname

3-phosphonopyruvate carboxy-lyase (2-phosphonoacetaldehyde-forming)

Reaction(IUBMB)

3-phosphonopyruvate = 2-phosphonoacetaldehyde + CO2 [RN:R04053]

Reaction(KEGG)

R04053

Substrate

3-phosphonopyruvate [CPD:C02798]

Product

2-phosphonoacetaldehyde [CPD:C03167];
CO2 [CPD:C00011]

Comment

The enzyme catalyses a step in the biosynthetic pathway of 2-aminoethylphosphonate, a component of the capsular polysaccharide complex of Bacteroides fragilis. Requires thiamine diphosphate and Mg2+ as cofactors. The enzyme is activated by the divalent cations Mg2+, Ca2+ and Mn2+. Pyruvate and sulfopyruvate can also act as substrates, but more slowly. This enzyme drives the reaction catalysed by EC 5.4.2.9, phosphoenolpyruvate mutase, in the thermodynamically unfavourable direction of 3-phosphonopyruvate formation [2]. It is the initial step in all of the major biosynthetic pathways of phosphonate natural products [3].

History

EC 4.1.1.82 created 2005

Pathway

ec00440

Phosphonate and phosphinate metabolism

ec00998

Biosynthesis of various antibiotics

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

ec01120

Microbial metabolism in diverse environments

Orthology

K09459

phosphonopyruvate decarboxylase

Genes

ZNE:

110841498

CSEC:

111875044

SGRE:

126298672

BROR:

134540720

FCD:

110847575

PPOI:

119111117 119111763

LGI:	LOTGIDRAFT_114966

PVUL:

126824792

PCAN:

112559357

HRJ:

124268737

OED:

125646416

MYI:

110448928

PMAX:

117336379

MCAF:

127705869

MMER:

123537598

RPHI:

132722180

DPOL:

127847049 127877104

OBI:

106874397

LAK:	106157387 106176585

NVE:

5511287

EPA:

110243717

ATEN:

116287539

ADF:

107333309

AMIL:

114948801

PDAM:

113684314

SPIS:

111344557

DGT:

114523267

XEN:

124452918

HMG:

100197891

HSY:

130629280

TET:	TTHERM_01287980

PTM:	GSPATT00025990001 GSPATT00026172001

SMIN:

v1.2.019412.t1(symbB.v1.2.019412.t1)

TBR:	Tb11.01.1120

TBG:	TbgDal_XI10470

TCR:

505965.50

HDE:

HDEF_0202

SRL:	SOD_c30100(bcpC)

SRY:	M621_16410

FSM:	CCS41_00900(aepY)

PROD:

PCO85_08035(aepY)

ECA:	ECA0488(fom2)

PATR:

EV46_02525

PATO:

GZ59_05040(fom2)

PCT:

PC1_0477

PCC:	PCC21_005020

PWA:	Pecwa_0573

PPAR:

A8F97_15525

PEC:

W5S_0591

PPOA:

BJK05_19420

PPUJ:

E2566_02930(aepY)

PARI:

I2D83_19360(aepY)

PCAC:

OI450_03790(aepY)

PCOA:

PJ912_15830(aepY)

LBQ:	CKQ53_06555(aepY)

LPOP:

I6N93_15655(aepY)

EPE:	CI789_05495(aepY)

PLF:	PANA5342_2584(ppd)

PAJ:

PAJ_2521

PAQ:	PAGR_g3819

EIC:	NT01EI_2702

XVA:	C7V42_03525(aepY)

XHY:	FZ025_12105(aepY)

XDY:	NYR95_03915(aepY)

PTRE:

I9H09_23710(aepY)

PPZ:	H045_01955

SDN:

Sden_1162

PMAW:

MACH26_33040

OSG:	BST96_06900

NOC:

Noc_1316

NHL:

Nhal_1305

NWA:

Nwat_1198

NWR:	E3U44_16830(aepY)

NTT:

TAO_1302

NTG:	NSCAC_0557(ppd)

ZPL:	ZBT109_1639

MPRF:

J8N69_05405(aepY)

SALN:

SALB1_2155

RPJ:	N234_04635

RME:	Rmet_1809(ppd)

CBW:	RR42_s0340

CPAU:

EHF44_14445(aepY)

COX:	E0W60_18820(aepY)

CCAM:

M5D45_07520(aepY)

BMA:	BMAA1769(ppd)

BMV:	BMASAVP1_0759(ppd)

BMAL:

DM55_4013(aepY)

BMAQ:

DM76_4709(aepY)

BMAI:

DM57_07160

BMAF:

DM51_3462(aepY)

BMAZ:

BM44_3973(aepY)

BMAB:

BM45_4750(aepY)

BPS:	BPSS0508 BPSS0609

BPM:	BURPS1710b_A2064(ppd) BURPS1710b_A2172(fom2)

BPL:	BURPS1106A_A0690(ppd) BURPS1106A_A0817(ppd)

BPD:	BURPS668_A0779(aepY_2) BURPS668_A0909(aepY_1)

BPSE:

BDL_3734(aepY) BDL_3836(aepY)

BPSM:

BBQ_5586(aepY) BBQ_5688(aepY)

BPSU:

BBN_3908(aepY) BBN_4008(aepY)

BPSD:

BBX_5571(aepY) BBX_5673(aepY)

BPZ:	BP1026B_II0563 BP1026B_II0673

BPQ:	BPC006_II0734 BPC006_II0865

BPK:	BBK_3882(aepY) BBK_5713(aepY)

BPSH:

DR55_4743(aepY) DR55_4844(aepY)

BPSA:

BBU_5437(aepY) BBU_5539(aepY)

BPSO:

X996_3789(aepY) X996_4594(aepY)

BUT:	X994_4010(aepY) X994_4112(aepY)

BTE:	BTH_II1909

BTQ:	BTQ_5191(aepY)

BTJ:	BTJ_3821(aepY)

BTZ:	BTL_4577(aepY) BTL_4677(aepY)

BTD:	BTI_5337(aepY)

BTV:	BTHA_5552(aepY)

BTHE:

BTN_4316(aepY)

BTHM:

BTRA_4581(aepY)

BTHA:

DR62_4262 DR62_4365

BTHL:

BG87_4648(aepY)

BOK:	DM82_4610(aepY) DM82_4704(aepY)

BOC:	BG90_5889(aepY) BG90_5981(aepY)

BUU:	WS70_20050

BSAV:

WS86_21235 WS86_21650

BHG:	I6G56_25500(aepY)

BUD:	AQ610_28105

BVI:	Bcep1808_4686

BVE:	AK36_4233(aepY)

BUR:	Bcep18194_B1915

BCM:	Bcenmc03_3399

BCH:	Bcen2424_4120

BCJ:

BCAM1244

BCEN:

DM39_3754(aepY)

BCEW:

DM40_4162(aepY)

BCEO:

I35_5093

BAM:

Bamb_3534

BAC:	BamMC406_4015

BMJ:	BMULJ_04038(ppd)

BMU:

Bmul_4472

BMK:	DM80_3633(aepY)

BMUL:

NP80_4147(aepY)

BCT:

GEM_4496

BCED:

DM42_3847(aepY)

BCEP:

APZ15_18455

BDL:	AK34_4231(aepY)

BPYR:

ABD05_29920

BCON:

NL30_06375

BUB:	BW23_4918(aepY)

BDF:	WI26_19320

BLAT:

WK25_23145

BTEI:

WS51_03915

BSEM:

WJ12_26080

BPSL:

WS57_07795

BMEC:

WJ16_24705

BSTG:

WT74_25010

BSTL:

BBJ41_19210

BANN:

JFN94_23425(aepY)

BARI:

NLX30_32415(aepY)

BAEN:

L3V59_19230(aepY)

BGL:	bglu_2g13470

BGU:	KS03_4594(aepY)

BUG:	BC1001_5204

BGF:	BC1003_4279

BGD:	bgla_2g13350

BGO:	BM43_5002(aepY)

BYI:	BYI23_A006820

BUK:

MYA_4543

BUE:	BRPE67_ACDS06760

BUL:	BW21_5017(aepY)

BUQ:	AC233_24005

BGP:	BGL_2c11760

BPLA:

bpln_2g12600

BUM:	AXG89_10165

BUI:	AX768_03890

BURK:

DM992_19620(aepY)

BXE:

Bxe_B2234

BXB:	DR64_4565(aepY)

BPH:

Bphy_3821

BGE:	BC1002_3394

BPX:	BUPH_05877

BPY:	Bphyt_5998

BUZ:	AYM40_23415

BFN:	OI25_4535(aepY)

BCAI:

K788_0000150

PSPW:

BJG93_18655(aepY)

PARA:

BTO02_27440

PARB:

CJU94_32425(aepY)

PHS:	C2L64_30755(aepY)

PTER:

C2L65_27415(aepY)

PGP:	CUJ91_19560(aepY)

PCJ:	CUJ87_30245(aepY)

PTS:	CUJ90_26945(aepY)

PCAF:

DSC91_002023

PMEG:

FNZ07_08535(aepY)

PTRO:

G5S35_19395(aepY)

PGIS:

I6I06_19280(aepY)

PACP:

FAZ97_15195(aepY)

PACS:

FAZ98_20210(aepY)

PEW:	KZJ38_30040(aepY)

PDIO:

PDMSB3_0866.1(ppd)

PBRY:

NDK50_32645(aepY)

PSAA:

QEN71_14450(aepY)

PKF:	RW095_11995(aepY)

PBON:

QS306_15250(aepY)

PPAI:

E1956_23910(aepY)

PPK:	U875_16970

PPNO:

DA70_09040

PPNM:

LV28_21765

PRB:	X636_17450

PPUL:

RO07_16155

PSPU:

NA29_20995

PAPI:

SG18_00145

PVE:	UC34_07415

POX:	MB84_11755

PFG:	AB870_18105

PNR:	AT302_26650

PAND:

DRB87_06675(aepY)

PFIB:

PI93_020430(aepY)

PCOM:

NTU39_08425(aepY)

CABA:

SBC2_10690

BUO:	BRPE64_ACDS07740

CABK:

NK8_07540(aepY)

TCAR:

U0034_22535(aepY)

AAA:

Acav_2123

MEU:	ACJ67_08965

AZO:

azo2699

AOA:

dqs_2834

AVI:

Avi_3414

REP:	IE4803_PB00124

ARA:

Arad_7868

AOL:

S58_09490

BROS:

QUH67_10085(aepY)

SIW:	GH266_09710(aepY)

RGI:	RGI145_09785

ROS:	CTJ15_07645(aepY)

RMUC:

FOB66_09670(aepY)

RMT:	IAI58_18635(aepY)

LCK:	HN018_01550(aepY)

AZZ:	DEW08_28015(aepY)

ECOG:

FIV45_08010(aepY)

SNEA:

NBZ79_03290(aepY)

HWI:	A0Z60_07475(aepY)

CJU:

C8J_1330

CHYO:

CHH_1592

CHW:	A2J15_004810(aepY)

CINF:

CINF_1347

ANT:	Arnit_2942

DLM:	DPPLL_12500

DAK:	DaAHT2_1859

DAL:

Dalk_1322

DLI:

dnl_05850

DAO:	Desac_2269

LLU:	AKJ09_10388

BSTO:

C0V70_16035(aepY)

BACI:

B1NLA3E_03310

BMQ:	BMQ_0785(aepY)

BMD:	BMD_0786(aepY)

BMH:	BMWSH_4463(ppd)

BMEG:

BG04_3079(aepY)

PTB:	DER53_11740(aepY)

PCAL:

BV455_03447

MEKU:

HUW50_16410(aepY)

BOU:	I5818_22335(aepY)

BLR:	BRLA_c034000

BRW:	GOP56_09090(aepY)

PPY:	PPE_04395 PPE_04790

PPOL:

X809_41425

PTA:	HPL003_06760

PIH:	UB51_20095 UB51_20635

PPEO:

ABE82_25175

PKB:	B4V02_00180 B4V02_16730

PAIH:

ASL14_12570

PLUT:

EI981_13660(aepY)

PCHI:

PC41400_18310(aepY)

PTHI:

NDS46_01340(aepY)

PKA:	PQ456_19755(aepY)

PNK:	AASFL403_21925

ADAU:

NZD86_21655(aepY)

EFF:	skT53_29660

SURL:

BI350_13785

PABS:

JIR001_16500

CTC:

CTC_01699

CTET:

BN906_01841

CBJ:	H04402_02797

CBE:

Cbei_4337

CBZ:

Cbs_4337

CBEI:

LF65_04861

CSR:	Cspa_c46180(bcpC)

CSB:	CLSA_c08740(bcpC)

CBUT:

ATN24_05945

CARG:

RSJ17_12815

CDY:	F3K33_22180(aepY)

CCAA:

KQH81_02880(aepY)

CNN:	CNEO_1088(ppd)

CGEL:

psyc5s11_47360

HHJ:	NQ487_01305(aepY)

RAL:	Rumal_1341

RCH:

RUM_11410

ALAC:

JYE50_04505(aepY) JYE50_12335(aepY)

AHC:	JYE49_05000(aepY)

BPEN:

NQ488_09085(aepY)

CBAF:

JS518_04520(aepY) JS518_12265(aepY)

RRK:	H8S51_002425(aepY)

BPRO:

PMF13cell1_05127(mdlC)

BCOC:

BLCOC_42160

CLE:	Clole_3575

HAS:	Halsa_0039

TIZ:	RBU61_14845(aepY)

SSG:	Selsp_0558

SELE:

ADJ74_04655

SELO:

AXE86_05285

SELT:

BCS37_10940

SDIA:

QU667_11315(aepY)

LCG:	L3BBH23_02730

MBJ:	KQ51_00728

OLS:

Olsu_0592

NBR:	O3I_021400

NTP:	CRH09_19450(aepY)

NOZ:	DMB37_08000(aepY)

NAH:	F5544_23985

SCO:	SCO6824(SC1A2.33c)

SALS:

SLNWT_3224

STRC:

AA958_29495

STRT:

A8713_00490

SGS:	AVL59_02545

SALW:

CP975_03130(aepY)

SALF:

SMD44_04408

SRJ:

SRO_1309

SGD:	ELQ87_04605

SGF:	HEP81_01275

SSEO:

D0Z67_12190(aepY)

SRIM:

CP984_37455(aepY)

STSU:

B7R87_30295

SDW:	K7C20_15035(aepY)

SGOB:

test1122_07760(aepY)

SCIR:

STRCI_003016(aepY)

STTN:

BSL84_13970

LSE:	F1C12_11065

RTC:	APU90_00560

CELH:

GXP71_14040(aepY)

TES:	BW730_00190

NAKE:

KGD83_08790(aepY)

SAIU:

J4H86_04285(aepY)

FAL:

FRAAL6378

AMYY:

YIM_29485

SSYI:

EKG83_20795(aepY)

KUT:	JJ691_31280

MPRN:

Q3V37_07940(aepY)

ASIC:

Q0Z83_111410(aepY)

AOU:	ACTOB_005082(aepY)

NHY:	JQS43_02330(aepY)

SNA:

Snas_5664

NAV:	JQS30_13660(aepY)

AYM:	YM304_30160

ARP:	NIES39_A00300

MPRO:

BJP34_15510

NED:	HUN01_29210(aepY)

TOQ:	HCG51_21870(aepY)

NCN:	BZZ01_05230

OTE:

Oter_2977

OBG:	Verru16b_03221

ELUT:

CKA38_13740(aepY)

TDE:

TDE_1414

TBE:	Trebr_0278

TPI:	TREPR_2365(aepY)

TPK:	JO40_09720

TPHG:

FUT81_06850(aepY)

TRI:	DYE50_04585(aepY)

TPAV:

HRQ91_06195(aepY)

TSK:	HRI97_05660(aepY)

SSM:	Spirs_4229

STA:	STHERM_c15600

SBU:	SpiBuddy_0273

SGP:	SpiGrapes_1559

TAZ:	TREAZ_2215(aepY)

SCD:	Spica_1332

BHC:	JFL75_01535(aepY)

TPX:	Turpa_2339

BIP:

Bint_1238

FSU:	Fisuc_0992

FSC:

FSU_1438

BTH:

BT_1719

BTHO:

Btheta7330_01296(ilvB)

BFR:	BF1833 BF2577

BFS:	BF9343_1815(aepY)

BFG:	BF638R_1868

BUN:	Bun01g_29030

BEG:	INE88_02863

BSTE:

K6V31_00390(aepY)

BDO:	EL88_10430

PARC:

CI960_12855(aepY)

PCOI:

LK433_14485(aepY)

DRC:	G0Q07_19265(aepY)

PCM:	AY601_0433

FUV:	JR347_10755(aepY)

RCG:	N7E81_15225(aepY)

FAX:	FUAX_43920

PROC:

Ptc2401_00815(ilvB_1)

NDE:	NIDE2902(ppd)

NKF:	Nkreftii_003418

NVA:	G3M78_03285(aepY)

METB:

AW729_03840

TAR:	TALC_00082

LOB:	NEF87_004218

PSYT:

DSAG12_01621(comE_1)

» show all

Reference

1 [PMID:12904299]

Authors

Zhang G, Dai J, Lu Z, Dunaway-Mariano D.

Title

The phosphonopyruvate decarboxylase from Bacteroides fragilis.

Journal

J Biol Chem 278:41302-8 (2003)
DOI:10.1074/jbc.M305976200

Reference

2 [PMID:8180189]

Authors

Seidel HM, Knowles JR.

Title

Interaction of inhibitors with phosphoenolpyruvate mutase: implications for the reaction mechanism and the nature of the active site.

Journal

Biochemistry 33:5641-6 (1994)
DOI:10.1021/bi00184a037

Reference

3 [PMID:9127192]

Authors

Nakashita H, Watanabe K, Hara O, Hidaka T, Seto H

Title

Studies on the biosynthesis of bialaphos. Biochemical mechanism of C-P bond formation: discovery of phosphonopyruvate decarboxylase which catalyzes the formation of phosphonoacetaldehyde from phosphonopyruvate.

Journal

J Antibiot (Tokyo) 50:212-9 (1997)
DOI:10.7164/antibiotics.50.212

Other DBs

ExplorEnz - The Enzyme Database:

4.1.1.82

IUBMB Enzyme Nomenclature:

4.1.1.82

ExPASy - ENZYME nomenclature database:

4.1.1.82

BRENDA, the Enzyme Database:

4.1.1.82

CAS:	151662-34-9

DBGET integrated database retrieval system