KEGG ENZYME: 4.1.1.99

ENZYME: 4.1.1.99

Entry

EC 4.1.1.99                 Enzyme

Name

phosphomevalonate decarboxylase

Class

Lyases;
Carbon-carbon lyases;
Carboxy-lyases

Sysname

ATP:(R)-5-phosphomevalonate carboxy-lyase (adding ATP; isopentenyl-phosphate-forming)

Reaction(IUBMB)

ATP + (R)-5-phosphomevalonate = ADP + phosphate + isopentenyl phosphate + CO2 [RN:R10561]

Reaction(KEGG)

R10561

Substrate

ATP [CPD:C00002];
(R)-5-phosphomevalonate [CPD:C01107]

Product

ADP [CPD:C00008];
phosphate [CPD:C00009];
isopentenyl phosphate [CPD:C20345];
CO2 [CPD:C00011]

Comment

The enzyme participates in a mevalonate pathway that occurs in halophilic archaea. The activity is also present in eubacteria of the Chloroflexi phylum. cf. EC 4.1.1.33, diphosphomevalonate decarboxylase, and EC 4.1.1.110, bisphosphomevalonate decarboxylase.

History

EC 4.1.1.99 created 2014, modified 2018

Pathway

ec00900

Terpenoid backbone biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K17942

phosphomevalonate decarboxylase

Genes

HAL:	VNG_0593G(dmd)

HSL:	OE_1893F(mvaD)

HANR:

LJ422_02475(mvaD)

HDL:	HALDL1_07090

HHB:	Hhub_1732(mvaD)

HAGS:

JT689_03750(mvaD)

HABO:

JRZ79_02255(mvaD)

HNO:	LT974_03595(mvaD)

HLU:	LT972_09845(mvaD)

HALH:

HTSR_1043(mvaD) HTSR_1765

HHSR:

HSR6_1076(mvaD) HSR6_1831(pmd)

HSU:	HLASF_0833(mvaD)

HSF:	HLASA_0830(mvaD)

HAHS:

HSRCO_1219(mvd1)

SALR:

FQU85_11735

HALR:

EFA46_007505

HJE:	HacjB3_11155

HDO:	MUK72_12405(mvaD) MUK72_18300

HALX:

M0R89_12935(mvaD)

HAXZ:

M0R88_13290(mvaD)

HAYC:

NGM10_03025(mvaD)

HAXY:

NGM07_00490(mvaD)

SALI:

L593_12340

SAIM:

K0C01_09265

HARA:

AArcS_1922(mvd1)

HMA:	rrnAC1489(dmd)

HHI:	HAH_2062(dmd)

HHN:	HISP_10500

HAB:	SG26_02805

HTA:	BVU17_10065

HALJ:

G9465_15195

HSIN:

KDQ40_03130

NPH:	NP_1580A(mvaD)

NMO:	Nmlp_1993(mvaD)

NHO:	HWV23_04855

NSAL:

HWV07_03955(mvaD)

HUT:

Huta_0691

HTI:

HTIA_0600

HALA:

Hrd1104_09580(mvaD)

HASV:

SVXHr_0902(mvaD)

HABN:

HBNXHr_0894(mvaD)

HMU:

Hmuk_2128

HALZ:

E5139_13780

HALL:

LC1Hm_1696(dmd)

HAZP:

GBQ70_13795

HALI:

BV210_02915

HSN:	DV733_13305

HDS:	HSR122_1854(mvd1)

HRR:	HZS55_09955(mvaD)

HPEL:

HZS54_15200

HLT:	I7X12_03205

HARC:

HARCEL1_02615

SSAI:

N0B31_03695(mvaD)

HAAD:

MW046_05125(mvaD)

HWA:	HQ_1525A(mvaD)

HWC:	Hqrw_1624(mvaD)

HVO:	HVO_1412(mvaD)

HME:	HFX_1486(dmd)

HGI:	ABY42_06940

HALE:

G3A49_10265

HLS:	KU306_11920

HLN:	SVXHx_1378(mvad)

HBO:	Hbor_18190

HAQ:	DU484_10010

HAJ:	DU500_10255

HAER:

DU502_07420

HRA:	EI982_06245

HLM:	DV707_07860

HALM:

FCF25_13955(mvaD)

HLA:

Hlac_1434

HALP:

DOS48_06945

HALB:

EKH57_03095

HEZZ:

EO776_08350

HALQ:

Hrr1229_014665

HSS:	J7656_08105

HSAI:

HPS36_13615

HAZZ:

KI388_06040

SRUB:

C2R22_08520

HAE:	halTADL_3034

HALN:

B4589_002050(mvaD)

HALG:

HUG10_06730

HALU:

HUG12_08730

HMP:	K6T50_02775

HRE:	K6T36_02605

HRM:	K6T25_11895

HACB:

Hbl1158_11835

HDF:	AArcSl_0776(mvaD)

HAH:	Halar_1389

HTU:

Htur_1087

HSAL:

JMJ58_03305(mvaD)

HAKZ:

J0X25_09245 J0X25_13120(mvaD)

NMG:	Nmag_3235(mvaD)

HXA:	Halxa_3857

NAT:

NJ7G_3246

NPE:	Natpe_2790

NVR:	FEJ81_12855

NPL:	FGF80_13460

NAY:	HYG81_17075

HALY:

HYG82_18705

HJT:	DVR14_03890

HLO:	J0X27_03355

NGE:	Natgr_0456

HRU:	Halru_0775

SAWL:

NGM29_17685(mvaD)

HALV:

NGM15_08900(mvaD)

NOU:	Natoc_1020

HLR:	HALLA_08960

HLC:	CHINAEXTREME19995

NAJ:	B1756_18005

NAG:	AArcMg_1739

NAN:	AArc1_1936

NARA:

QQ977_00285(mvaD)

NBG:	DV706_01870(mvaD)

NAS:	GCU68_11880(mvaD)

HDA:	BB347_03210

CSU:	CSUB_C1629

» show all

Reference

1 [PMID:24327557]

Authors

Dellas N, Thomas ST, Manning G, Noel JP

Title

Discovery of a metabolic alternative to the classical mevalonate pathway.

Journal

Elife 2:e00672 (2013)
DOI:10.7554/eLife.00672

Reference

2 [PMID:24375100]

Authors

Vannice JC, Skaff DA, Keightley A, Addo JK, Wyckoff GJ, Miziorko HM

Title

Identification in Haloferax volcanii of phosphomevalonate decarboxylase and isopentenyl phosphate kinase as catalysts of the terminal enzyme reactions in an archaeal alternate mevalonate pathway.

Journal

J Bacteriol 196:1055-63 (2014)
DOI:10.1128/JB.01230-13

Sequence

[hvo:HVO_1412]

Reference

3 [PMID:31268677]

Authors

Thomas ST, Louie GV, Lubin JW, Lundblad V, Noel JP

Title

Substrate Specificity and Engineering of Mevalonate 5-Phosphate Decarboxylase.

Journal

ACS Chem Biol 14:1767-1779 (2019)
DOI:10.1021/acschembio.9b00322