KEGG   ENZYME: 4.1.2.49
Entry
EC 4.1.2.49                 Enzyme                                 
Name
L-allo-threonine aldolase
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
Sysname
L-allo-threonine acetaldehyde-lyase (glycine-forming)
Reaction(IUBMB)
L-allo-threonine = glycine + acetaldehyde [RN:R06171]
Reaction(KEGG)
R06171
Substrate
L-allo-threonine [CPD:C05519]
Product
glycine [CPD:C00037];
acetaldehyde [CPD:C00084]
Comment
Requires pyridoxal phosphate. This enzyme, characterized from the bacterium Aeromonas jandaei, is specific for L-allo-threonine and can not act on either L-threonine or L-serine. Different from EC 4.1.2.5, L-threonine aldolase, and EC 4.1.2.48, low-specificity L-threonine aldolase. A previously listed enzyme with this name, EC 4.1.2.6, was deleted in 1971 after it was found to be identical to EC 2.1.2.1, glycine hydroxymethyltransferase.
History
EC 4.1.2.49 created 2011
Pathway
ec00260  Glycine, serine and threonine metabolism
ec01100  Metabolic pathways
Orthology
K20801  L-allo-threonine aldolase
Genes
AHAAHA_1795
AHYAHML_09870
AHDAI20_10070
AHRV428_10130
AHPV429_10135
AHJV469_13360
AHHRY45_09770
AHIVU14_13575
AAJBOQ57_08800
ASAASA_1753(ltaA)
AEOO23A_p1041
AVRB565_2324
AVOAMS64_14365
AMEDB224_1834
ASRWL1483_125(ltaA)
ADHCK627_17035
ACAVVI35_12120
AEMCK911_08735
AEAC2U39_12470
ARVC7N77_12900
AESC2U30_01410
AELNCTC12917_02364(ltaA)
ASIMFE240_06260(ltaE)
AALLI6G90_03445(ltaE)
AJDI6H43_19765(ltaE)
ARIVKYK33_08245(ltaE)
AEJE5E97_14205(ltaE)
ABESIU367_12925(ltaE)
MENYLSQ66_10955
BLUTEW640_01865
ASERAsera_33190
ACAFCA12_40050(ltaA)
CCOSPan44_20940(ltaA)
 » show all
Reference
1  [PMID:9228760]
  Authors
Kataoka M, Wada M, Nishi K, Yamada H, Shimizu S
  Title
Purification and characterization of L-allo-threonine aldolase from Aeromonas jandaei DK-39.
  Journal
FEMS Microbiol Lett 151:245-8 (1997)
DOI:10.1111/j.1574-6968.1997.tb12577.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.1.2.49
IUBMB Enzyme Nomenclature: 4.1.2.49
ExPASy - ENZYME nomenclature database: 4.1.2.49
BRENDA, the Enzyme Database: 4.1.2.49

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